Comparison of human and chimpanzee ξ1 blobin genes

Cary Willard, Elsie Wong, John F. Hess, Che Kun James Shen, Barbara Chapman, Allan C. Wilson, Carl W. Schmid

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The DNA base sequences of the entire chimpanzee ξ1 globin gene and an additional 1 kb of DNA flanking both the human and chimpanzee genes have been determined. Whereas the human ξ1 gene contains a termination codon in the sixth position, the chimpanzee gene appears to be functional. This finding confirms Proudfoot et al.'s suggestion that the human ξ1 gene was recently inactivated. Like the corresponding human ξ1 and ξ2 genes, the first and second introns of the chimpanzee ξ1 gene are occupied largely by tandem repeats of short oligonucleotides. These tandem repeats have undergone several rearrangements since the divergence of the human and chimpanzee ξ1 genes.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalJournal of Molecular Evolution
Volume22
Issue number4
DOIs
Publication statusPublished - Dec 1985
Externally publishedYes

Keywords

  • Globin genes
  • Primate evolution
  • Tandem repeats

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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  • Cite this

    Willard, C., Wong, E., Hess, J. F., James Shen, C. K., Chapman, B., Wilson, A. C., & Schmid, C. W. (1985). Comparison of human and chimpanzee ξ1 blobin genes. Journal of Molecular Evolution, 22(4), 309-315. https://doi.org/10.1007/BF02115686