Comparison of gram-negative and gram-positive hematogenous pyogenic spondylodiscitis: Clinical characteristics and outcomes of treatment

Ching Yu Lee, Meng Huang Wu, Chin Chang Cheng, Tsung-Jen Huang, Yu Tsung Huang, Chien Yin Lee, Jou Chen Huang, Yen Yao Li

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: To the best of our knowledge, no study has compared gram-negative bacillary hematogenous pyogenic spondylodiscitis (GNB-HPS) with gram-positive coccal hematogenous pyogenic spondylodiscitis (GPC-HPS) regarding their clinical characteristics and outcomes. Methods: From January 2003 to January 2013, 54 patients who underwent combined antibiotic and surgical therapy in the treatment of hematogenous pyogenic spondylodiscitis were included. Results: Compared with 37 GPC-HPS patients, the 17 GNB-HPS patients were more often found to be older individuals, a history of cancer, and a previous history of symptomatic urinary tract infection. They also had a less incidence of epidural abscess formation compared with GPC-HPS patients from findings on magnetic resonance imaging (MRI). Constitutional symptoms were the primary reasons for initial physician visits in GNB-HPS patients whereas pain in the affected spinal region was the most common manifestation in GPC-HPS patients at initial visit. The clinical outcomes of GNB-HPS patients under combined surgical and antibiotic treatment were not different from those of GPC-HPS patients. In multivariate analysis, independent predicting risk factors for GNB-HPS included a malignant history and constitutional symptoms and that for GPC-HPS was epidural abscess. Conclusions: The clinical manifestations and MRI presentations of GNB-HPS were distinguishable from those of GPC-HPS.

Original languageEnglish
Article number735
JournalBMC Infectious Diseases
Volume16
Issue number1
DOIs
Publication statusPublished - Dec 6 2016

Keywords

  • Gram-negative infection
  • Gram-positive infection
  • Hematogenous pyogenic spondylodiscitis

ASJC Scopus subject areas

  • Infectious Diseases

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