Comparison of escitalopram and paroxetine in the treatment of major depressive disorder

Huang Li Lin, Ya Ting Hsu, Chia Yih Liu, Chia Hui Chen, Mei Chun Hsiao, Yu Li Liu, Winston W. Shen, Chin Fu Hsiao, Shen Ing Liu, Liang Huey Chang, Hwa Sheng Tang, Hsiang Ling Lai, Pei Sheng Lin, Keh Ming Lin, Hsiao Hui Tsou

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This is a single-blind, parallel, flexible-dose study to compare the efficacy and tolerability of escitalopram and paroxetine in the treatment of patients with major depressive disorder. We recruited 399 patients from the outpatient clinics of five hospitals in northern Taiwan. Patients were administered either escitalopram (10-30 mg) or paroxetine (20-40 mg) according to the judgment of clinicians. These patients were assessed using the Hamilton Rating Scale for Depression (HAM-D) and the Hamilton Rating Scale for Anxiety at weeks 0, 1, 2, 4, 6, and 8. A total of 302 patients fulfilled the evaluation criteria and were included in a statistical analysis. We found that escitalopram induced more significant symptom reduction and response rate in terms of the mean HAM-D scores at week 6 (P

Original languageEnglish
Pages (from-to)339-345
Number of pages7
JournalInternational Clinical Psychopharmacology
Volume28
Issue number6
DOIs
Publication statusPublished - Nov 2013

Keywords

  • Depression
  • Efficacy
  • Escitalopram
  • Paroxetine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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