Comparison of efficacy and safety of gabapentin and duloxetine in painful diabetic peripheral neuropathy: A systematic review and meta-analysis of randomised controlled trials

Yuan Chun Ko, Che Hsiung Lee, Chung Sheng Wu, Yu Jui Huang

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In patients with diabetes mellitus, painful diabetic peripheral neuropathy (PDPN) is a frequent complication and can cause poor quality of life. We compared the efficacy and safety of duloxetine with those of gabapentin in patients with PDPN through a systematic review and meta-analysis of randomised controlled trials. Materials and Methods: PubMed, Embase and the Cochrane Library were searched for eligible studies published from database inception to January 2021. Visual Analogue Scale (VAS), sleep interference score, Clinical Global Impression of Change (CGIC), Patient Global Impression of Change (PGIC), Diabetic Neuropathy Symptom (DNS) score, Diabetic Neuropathic Examination (DNE) score, Neuropathic Disability Score (NDS) and side effects were used to compare duloxetine and gabapentin in patients with PDPN. Results: Three eligible randomised controlled trials involving 290 patients were included. No significant differences were observed between patients receiving duloxetine and gabapentin with respect to VAS (mean change difference = −1.23, 95% CI, −6.09 to 3.62; P =.62), sleep interference score (mean change difference = 0.42, 95% CI, −0.15 to 1.00; P =.15), CGIC (mean difference = 0.04, 95% CI, −0.11 to 0.20; P =.60), PGIC (mean difference= 0.24, 95% CI, −0.13 to 0.60; P =.21), DNS (mean change difference = 0.14, 95% CI, −0.35 to 0.63; P =.58), DNE (mean change difference = 0.26, 95% CI, −0.35 to 0.86; P =.41) and NDS (mean change difference = 0.30, 95% CI, −0.02 to 0.63; P =.07). Conclusions: No significant differences were observed in the efficacy of duloxetine and gabapentin when treating patients with PDPN.

Original languageEnglish
Article numbere14576
JournalInternational Journal of Clinical Practice
Volume75
Issue number11
DOIs
Publication statusPublished - Nov 2021

ASJC Scopus subject areas

  • Medicine(all)

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