Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China

Xinyi Niu, Kin Fai Ho, Hsiao Chi Chuang, Jian Sun, Yu Huang, Tafeng Hu, Hongmei Xu, Jing Duan, Ka Hei Lui, Junji Cao

Research output: Contribution to journalArticle

Abstract

The chemical and bioreactivity properties of fine particulate matter (PM2.5) in indoor and outdoor environments in Xi'an were characterized, and the lung function of various participants was investigated. The concentrations of polycyclic aromatic hydrocarbons (PAHs), oxygenated polycyclic aromatic hydrocarbons, and nitrated polycyclic aromatic hydrocarbons were higher in outdoor environments than in indoor environments; in addition, urban areas had higher concentrations of these compounds than did suburban areas, with fossil fuel combustion likely being the primary source. Moreover, PM2.5-induced inflammation was higher in urban areas than in suburban areas. Indoor environments with coal combustion emissions showed relatively higher oxidative potential and inflammation. Moderate (phenanthrene) to strong (acenaphthylene and benzo(a)pyrene) correlations were observed between selected PAHs against interleukin 6 (IL-6), 8-hydroxy-desoxyguanosine (8-OHdG), and necrosis factor-α (TNF-α). Moreover, 9-fluorenone, 9,10-anthraquinone, and 5,12-naphthacenequinone exhibited higher oxidative stress and inflammation than did their parent PAHs. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were negatively correlated with 8-OHdG, and FEV1/FVC was negatively correlated with TNF-α and IL-6. These findings—which integrates PM2.5 with lung function and bioreactivity analyses—suggest that coal burning, especially indoors, could elevate the cytotoxicity of PM2.5 to the occupants and that chronic exposure may lead to a decline in lung function.

Original languageEnglish
Article number116929
JournalAtmospheric Environment
Volume216
DOIs
Publication statusPublished - Nov 1 2019

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PAH
suburban area
urban area
phenanthrene
pyrene
fossil fuel
particulate matter
combustion
comparison
aromatic compound
cytotoxicity
coal
indoor environment

Keywords

  • Bioreactivity
  • Lung function
  • PAHs
  • PM

ASJC Scopus subject areas

  • Environmental Science(all)
  • Atmospheric Science

Cite this

Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China. / Niu, Xinyi; Ho, Kin Fai; Chuang, Hsiao Chi; Sun, Jian; Huang, Yu; Hu, Tafeng; Xu, Hongmei; Duan, Jing; Lui, Ka Hei; Cao, Junji.

In: Atmospheric Environment, Vol. 216, 116929, 01.11.2019.

Research output: Contribution to journalArticle

Niu, Xinyi ; Ho, Kin Fai ; Chuang, Hsiao Chi ; Sun, Jian ; Huang, Yu ; Hu, Tafeng ; Xu, Hongmei ; Duan, Jing ; Lui, Ka Hei ; Cao, Junji. / Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China. In: Atmospheric Environment. 2019 ; Vol. 216.
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