Comparison of coasting and intravenous albumin in the prevention of ovarian hyperstimulation syndrome

Chin Der Chen, Kuang Han Chao, Jehn Hsiahn Yang, Shee Uan Chen, Hong Nerng Ho, Yu Shih Yang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: To compare the efficacy of coasting to prevent ovarian hyperstimulation syndrome (OHSS) with i.v. albumin and to determine if different timing of gonadotropin coasting would affect the IVF outcomes. Design: Retrospective study. Setting: University hospital-based IVF program. Patient(s): One hundred sixty-two women undergoing IVF treatment cycles who were considered to be at high risk for developing OHSS. Intervention(s): Gonadotropin administration was withheld in 60 patients: either coasting occurred before follicular maturation (early coasting subset, n = 28) or follicular maturity was attained before coasting (late coasting subset, n = 32). Outcomes were compared in 102 patients at risk for OHSS who received i.v. albumin on the day of oocyte retrieval. Main outcome measure(s): Incidence of OHSS and outcome parameters. Result(s): Although the fertilization rates and the incidence of OHSS did not differ significantly between the coasting and i.v. albumin groups, the mean number of oocytes retrieved, the pregnancy rates, and implantation rates were significantly lower in the coasting group. There is no statistical difference in the entire outcome examined and the incidence of OHSS between the early and late coasting subsets. Conclusion(s): Coasting is as effective as i.v. albumin in preventing OHSS in high-risk patients but yields inferior pregnancy rates. Early coasting is as successful as late coasting in preventing OHSS with similar IVF outcome.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalFertility and Sterility
Volume80
Issue number1
DOIs
Publication statusPublished - Jul 1 2003
Externally publishedYes

Fingerprint

Ovarian Hyperstimulation Syndrome
Albumins
Pregnancy Rate
Gonadotropins
Incidence
Oocyte Retrieval
Fertilization
Oocytes
Retrospective Studies
Outcome Assessment (Health Care)

Keywords

  • Albumin
  • Coasting
  • IVF outcome
  • Ovarian hyperstimulation syndrome

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Comparison of coasting and intravenous albumin in the prevention of ovarian hyperstimulation syndrome. / Chen, Chin Der; Chao, Kuang Han; Yang, Jehn Hsiahn; Chen, Shee Uan; Ho, Hong Nerng; Yang, Yu Shih.

In: Fertility and Sterility, Vol. 80, No. 1, 01.07.2003, p. 86-90.

Research output: Contribution to journalArticle

Chen, Chin Der ; Chao, Kuang Han ; Yang, Jehn Hsiahn ; Chen, Shee Uan ; Ho, Hong Nerng ; Yang, Yu Shih. / Comparison of coasting and intravenous albumin in the prevention of ovarian hyperstimulation syndrome. In: Fertility and Sterility. 2003 ; Vol. 80, No. 1. pp. 86-90.
@article{e9cc29d9e6b84edba78d9dce18703e10,
title = "Comparison of coasting and intravenous albumin in the prevention of ovarian hyperstimulation syndrome",
abstract = "Objective: To compare the efficacy of coasting to prevent ovarian hyperstimulation syndrome (OHSS) with i.v. albumin and to determine if different timing of gonadotropin coasting would affect the IVF outcomes. Design: Retrospective study. Setting: University hospital-based IVF program. Patient(s): One hundred sixty-two women undergoing IVF treatment cycles who were considered to be at high risk for developing OHSS. Intervention(s): Gonadotropin administration was withheld in 60 patients: either coasting occurred before follicular maturation (early coasting subset, n = 28) or follicular maturity was attained before coasting (late coasting subset, n = 32). Outcomes were compared in 102 patients at risk for OHSS who received i.v. albumin on the day of oocyte retrieval. Main outcome measure(s): Incidence of OHSS and outcome parameters. Result(s): Although the fertilization rates and the incidence of OHSS did not differ significantly between the coasting and i.v. albumin groups, the mean number of oocytes retrieved, the pregnancy rates, and implantation rates were significantly lower in the coasting group. There is no statistical difference in the entire outcome examined and the incidence of OHSS between the early and late coasting subsets. Conclusion(s): Coasting is as effective as i.v. albumin in preventing OHSS in high-risk patients but yields inferior pregnancy rates. Early coasting is as successful as late coasting in preventing OHSS with similar IVF outcome.",
keywords = "Albumin, Coasting, IVF outcome, Ovarian hyperstimulation syndrome",
author = "Chen, {Chin Der} and Chao, {Kuang Han} and Yang, {Jehn Hsiahn} and Chen, {Shee Uan} and Ho, {Hong Nerng} and Yang, {Yu Shih}",
year = "2003",
month = "7",
day = "1",
doi = "10.1016/S0015-0282(03)00548-X",
language = "English",
volume = "80",
pages = "86--90",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Comparison of coasting and intravenous albumin in the prevention of ovarian hyperstimulation syndrome

AU - Chen, Chin Der

AU - Chao, Kuang Han

AU - Yang, Jehn Hsiahn

AU - Chen, Shee Uan

AU - Ho, Hong Nerng

AU - Yang, Yu Shih

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Objective: To compare the efficacy of coasting to prevent ovarian hyperstimulation syndrome (OHSS) with i.v. albumin and to determine if different timing of gonadotropin coasting would affect the IVF outcomes. Design: Retrospective study. Setting: University hospital-based IVF program. Patient(s): One hundred sixty-two women undergoing IVF treatment cycles who were considered to be at high risk for developing OHSS. Intervention(s): Gonadotropin administration was withheld in 60 patients: either coasting occurred before follicular maturation (early coasting subset, n = 28) or follicular maturity was attained before coasting (late coasting subset, n = 32). Outcomes were compared in 102 patients at risk for OHSS who received i.v. albumin on the day of oocyte retrieval. Main outcome measure(s): Incidence of OHSS and outcome parameters. Result(s): Although the fertilization rates and the incidence of OHSS did not differ significantly between the coasting and i.v. albumin groups, the mean number of oocytes retrieved, the pregnancy rates, and implantation rates were significantly lower in the coasting group. There is no statistical difference in the entire outcome examined and the incidence of OHSS between the early and late coasting subsets. Conclusion(s): Coasting is as effective as i.v. albumin in preventing OHSS in high-risk patients but yields inferior pregnancy rates. Early coasting is as successful as late coasting in preventing OHSS with similar IVF outcome.

AB - Objective: To compare the efficacy of coasting to prevent ovarian hyperstimulation syndrome (OHSS) with i.v. albumin and to determine if different timing of gonadotropin coasting would affect the IVF outcomes. Design: Retrospective study. Setting: University hospital-based IVF program. Patient(s): One hundred sixty-two women undergoing IVF treatment cycles who were considered to be at high risk for developing OHSS. Intervention(s): Gonadotropin administration was withheld in 60 patients: either coasting occurred before follicular maturation (early coasting subset, n = 28) or follicular maturity was attained before coasting (late coasting subset, n = 32). Outcomes were compared in 102 patients at risk for OHSS who received i.v. albumin on the day of oocyte retrieval. Main outcome measure(s): Incidence of OHSS and outcome parameters. Result(s): Although the fertilization rates and the incidence of OHSS did not differ significantly between the coasting and i.v. albumin groups, the mean number of oocytes retrieved, the pregnancy rates, and implantation rates were significantly lower in the coasting group. There is no statistical difference in the entire outcome examined and the incidence of OHSS between the early and late coasting subsets. Conclusion(s): Coasting is as effective as i.v. albumin in preventing OHSS in high-risk patients but yields inferior pregnancy rates. Early coasting is as successful as late coasting in preventing OHSS with similar IVF outcome.

KW - Albumin

KW - Coasting

KW - IVF outcome

KW - Ovarian hyperstimulation syndrome

UR - http://www.scopus.com/inward/record.url?scp=0038045257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038045257&partnerID=8YFLogxK

U2 - 10.1016/S0015-0282(03)00548-X

DO - 10.1016/S0015-0282(03)00548-X

M3 - Article

VL - 80

SP - 86

EP - 90

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 1

ER -