Abstract
Objective: We sought to determine whether Charlson comorbidity index (CCI) or Kaplan-Feinstein index (KFI) is a better predictor of prognosis in patients with stage I NSCLC after surgical resection. Methods: A retrospective study of medical records of 426 patients with stage I lung cancer having complete surgical resection from 1995 to 2000 was performed. Data collected included age, gender, smoking history, resection type, pleural invasion status, and tumor type and size. Comorbidity score was determined using Charlson comorbidity index and Kaplan-Feinstein index. Both univariate and multivariate analyses were used to evaluate prognostic factors. Results: Three hundred and twenty-eight male (76.99%) and 98 female (23.01%) patients had a mean age of 67.07 years (range 19-88 years). Median duration of follow-up was 60.32 months. Total follow-up rate was 95.1%. Distribution of CCI score was: 0, 236 (55.40%); 1, 112 (26.29%); ≥2, 78 (18.31%). Overall KFI score was: none, 247 (57.98%); mild, 126 (29.58%); moderate, 43 (10.09%); and severe, 10 (2.35%). In univariate analyses, patients aged ≥65 years, male, smokers, CCI score ≥2, extensive resection and pathological stage IB cancer had poorer 5-year survival. In multivariate logistic regression analysis, age ≥65 years, pneumonectomy, CCI score ≥2, and stage IB cancer were independent prognostic factors for poorer 5-year survival. Conclusions: Patients with CCI ≥2 had higher perioperative mortality and death from non-cancer causes after surgery compared to patients with CCI
| Original language | English |
|---|---|
| Pages (from-to) | 877-881 |
| Number of pages | 5 |
| Journal | European Journal of Cardio-thoracic Surgery |
| Volume | 32 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2007 |
| Externally published | Yes |
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Keywords
- Charlson score
- Comorbidity
- Kaplan-Feinstein index
- Lung cancer
- Survival analysis
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Surgery
Cite this
Comparison of Charlson comorbidity index and Kaplan-Feinstein index in patients with stage I lung cancer after surgical resection. / Wang, Chien Ying; Lin, Yu Sen; Tzao, Ching; Lee, Hui Chen; Huang, Min Hsiung; Hsu, Wen Hu; Hsu, Han Shui.
In: European Journal of Cardio-thoracic Surgery, Vol. 32, No. 6, 12.2007, p. 877-881.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of Charlson comorbidity index and Kaplan-Feinstein index in patients with stage I lung cancer after surgical resection
AU - Wang, Chien Ying
AU - Lin, Yu Sen
AU - Tzao, Ching
AU - Lee, Hui Chen
AU - Huang, Min Hsiung
AU - Hsu, Wen Hu
AU - Hsu, Han Shui
PY - 2007/12
Y1 - 2007/12
N2 - Objective: We sought to determine whether Charlson comorbidity index (CCI) or Kaplan-Feinstein index (KFI) is a better predictor of prognosis in patients with stage I NSCLC after surgical resection. Methods: A retrospective study of medical records of 426 patients with stage I lung cancer having complete surgical resection from 1995 to 2000 was performed. Data collected included age, gender, smoking history, resection type, pleural invasion status, and tumor type and size. Comorbidity score was determined using Charlson comorbidity index and Kaplan-Feinstein index. Both univariate and multivariate analyses were used to evaluate prognostic factors. Results: Three hundred and twenty-eight male (76.99%) and 98 female (23.01%) patients had a mean age of 67.07 years (range 19-88 years). Median duration of follow-up was 60.32 months. Total follow-up rate was 95.1%. Distribution of CCI score was: 0, 236 (55.40%); 1, 112 (26.29%); ≥2, 78 (18.31%). Overall KFI score was: none, 247 (57.98%); mild, 126 (29.58%); moderate, 43 (10.09%); and severe, 10 (2.35%). In univariate analyses, patients aged ≥65 years, male, smokers, CCI score ≥2, extensive resection and pathological stage IB cancer had poorer 5-year survival. In multivariate logistic regression analysis, age ≥65 years, pneumonectomy, CCI score ≥2, and stage IB cancer were independent prognostic factors for poorer 5-year survival. Conclusions: Patients with CCI ≥2 had higher perioperative mortality and death from non-cancer causes after surgery compared to patients with CCI
AB - Objective: We sought to determine whether Charlson comorbidity index (CCI) or Kaplan-Feinstein index (KFI) is a better predictor of prognosis in patients with stage I NSCLC after surgical resection. Methods: A retrospective study of medical records of 426 patients with stage I lung cancer having complete surgical resection from 1995 to 2000 was performed. Data collected included age, gender, smoking history, resection type, pleural invasion status, and tumor type and size. Comorbidity score was determined using Charlson comorbidity index and Kaplan-Feinstein index. Both univariate and multivariate analyses were used to evaluate prognostic factors. Results: Three hundred and twenty-eight male (76.99%) and 98 female (23.01%) patients had a mean age of 67.07 years (range 19-88 years). Median duration of follow-up was 60.32 months. Total follow-up rate was 95.1%. Distribution of CCI score was: 0, 236 (55.40%); 1, 112 (26.29%); ≥2, 78 (18.31%). Overall KFI score was: none, 247 (57.98%); mild, 126 (29.58%); moderate, 43 (10.09%); and severe, 10 (2.35%). In univariate analyses, patients aged ≥65 years, male, smokers, CCI score ≥2, extensive resection and pathological stage IB cancer had poorer 5-year survival. In multivariate logistic regression analysis, age ≥65 years, pneumonectomy, CCI score ≥2, and stage IB cancer were independent prognostic factors for poorer 5-year survival. Conclusions: Patients with CCI ≥2 had higher perioperative mortality and death from non-cancer causes after surgery compared to patients with CCI
KW - Charlson score
KW - Comorbidity
KW - Kaplan-Feinstein index
KW - Lung cancer
KW - Survival analysis
UR - http://www.scopus.com/inward/record.url?scp=35948984116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35948984116&partnerID=8YFLogxK
U2 - 10.1016/j.ejcts.2007.09.008
DO - 10.1016/j.ejcts.2007.09.008
M3 - Article
C2 - 17920921
AN - SCOPUS:35948984116
VL - 32
SP - 877
EP - 881
JO - European Journal of Cardio-thoracic Surgery
JF - European Journal of Cardio-thoracic Surgery
SN - 1010-7940
IS - 6
ER -