Comparison of Carotid Ultrasound Indices and the Triglyceride Glucose Index in Hypertensive and Normotensive Community-Dwelling Individuals: A Case Control Study for Evaluating Atherosclerosis

Javad Alizargar, Chyi Huey Bai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and objectives: Hypertension (HTN) is an important risk factor for cardiovascular diseases. High blood pressure is a major cause of atherosclerosis which leads to myocardial infarction and stroke. Insulin resistance (IR) is correlated with HTN and atherosclerosis. To determine differences between the effects of HTN on the intima media thicknesses (IMTs) of the internal (ICA), external (ECA), and common carotid arteries (CCA), and evaluate the carotid plaque presence between hypertensive and normotensive individuals, a case-control study was designed among community-dwelling individuals. The relationship between the triglyceride glucose (TyG) index and atherosclerosis was also investigated in this study. Materials and Methods: Data from 77 hypertensive and 199 normotensive individuals were analyzed in this study. Results: The IMTs of the CCA, ICA, and ECA, and the TyG index were all higher in hypertensive individuals compared to the control group (all p < 0.05). After controlling for age, sex, the body-mass index, and TyG index, HTN was an independent predictor of a high CCA IMT (odds ratio (OR) = 2.48; 95% confidence interval (CI) = 1.24⁻4.93) and presence of plaque (OR = 2.36; CI = 1.15⁻4.85) in the carotid artery. Conclusions: HTN was an independent risk of carotid IMT thickening and atherosclerosis. TyG index could only predict the CCA IMT independent of other risk factors (OR = 2.09; CI = 1.07⁻4.09).

Original languageEnglish
JournalMedicina (Kaunas, Lithuania)
Volume54
Issue number5
DOIs
Publication statusPublished - Oct 11 2018

Keywords

  • atherosclerosis
  • carotid artery
  • carotid intima media thickness
  • hypertension
  • insulin resistance
  • risk factor
  • triglyceride glucose index

ASJC Scopus subject areas

  • Medicine(all)

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