Comparison of antihypertensive effects of nicardipine with nitroglycerin for perioperative hypertension.

Ta-Liang Chen, W. Z. Sun, Y. J. Cheng, T. S. Lee, S. Y. Lin, C. J. Lin

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: To compare the efficacy of intravenous (iv) nicardipine with nitroglycerin for the treatment for patients with perioperative hypertension. METHODS: Forty patients with perioperative hypertension randomly divided into two groups were treated with intravenous calcium entry blocker, nicardipine, or vasodilator, nitroglycerin. Haemodynamic measurements including mean arterial and pulmonary arterial pressure, central venous and pulmonary capillary wedge pressure, and cardiac output were recorded; peripheral and pulmonary vascular resistance were calculated. RESULTS: Both medications were effective in reducing blood pressure and controlling haemodynamics. During the maintenance by continuous iv infusion, nicardipine controlled hypertension more rapidly than nitroglycerin (nicardipine 10.5 +/- 2.5 min and nitroglycerin 18.7 +/- 2.8 min, p <0.05) without significant alteration in heart rate. The total frequency of dose adjustments required to achieve therapeutic response was significantly less in the nicardipine-treated group (2.5 +/- 0.3 for nicardipine and 6.2 +/- 1.4 for nitroglycerin, p <0.05). Incidence of hypotensive episodes during the infusion were observed in both groups [nicardipine 5% (1/20) and nitroglycerin 30% (6/20), p <0.05]. CONCLUSIONS: Intravenous nicardipine is as effective as nitroglycerin in the treatment of perioperative hypertension. Specific advantages have been identified such as stable dose-response effect, less hypotensive and tachycardial effects during the use of iv nicardipine in treatment of hypertensive patients.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalActa Anaesthesiologica Sinica
Volume33
Issue number4
Publication statusPublished - Dec 1995
Externally publishedYes

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Nicardipine
Nitroglycerin
Antihypertensive Agents
Hypertension
Hemodynamics
Pulmonary Wedge Pressure
Therapeutics
Vasodilator Agents
Intravenous Infusions
Cardiac Output
Vascular Resistance
Arterial Pressure
Heart Rate
Maintenance
Blood Pressure
Calcium
Lung

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Comparison of antihypertensive effects of nicardipine with nitroglycerin for perioperative hypertension. / Chen, Ta-Liang; Sun, W. Z.; Cheng, Y. J.; Lee, T. S.; Lin, S. Y.; Lin, C. J.

In: Acta Anaesthesiologica Sinica, Vol. 33, No. 4, 12.1995, p. 199-204.

Research output: Contribution to journalArticle

Chen, Ta-Liang ; Sun, W. Z. ; Cheng, Y. J. ; Lee, T. S. ; Lin, S. Y. ; Lin, C. J. / Comparison of antihypertensive effects of nicardipine with nitroglycerin for perioperative hypertension. In: Acta Anaesthesiologica Sinica. 1995 ; Vol. 33, No. 4. pp. 199-204.
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