Comparison between in-hospital stroke and community-onset stroke treated with endovascular thrombectomy

Min Yi Lu, Chih Hao Chen, Shin Joe Yeh, Li Kai Tsai, Chung Wei Lee, Sung Chun Tang, Jiann Shing Jeng

Research output: Contribution to journalArticle

Abstract

Objective In-hospital stroke (IHS) is an uncommon but serious medical emergency. Early recanalization through endovascular thrombectomy (EVT) may offer a vital therapeutic choice. This study compared the clinical features and outcomes between IHS and community-onset stroke (COS). Methods From a single-center registry of 2813 patients with ischemic stroke, those who had received EVT for acute ischemic stroke were included and classified into the IHS and COS groups based on their stroke onset scenario. We compared the outcomes including successful recanalization, symptomatic intracranial hemorrhage, functional independence (modified Rankin Scale score, 0–2) at 90 days, and mortality between the two groups. Results A total of 24 patients with IHS (mean age, 70 years; 54% men) and 105 patients with COS (mean age, 73 years; 47% men) were included. The most frequently reported reasons for admission in patients with IHS were cardiovascular and oncological diseases. The initial National Institutes of Health Stroke Scale (NIHSS) scores and main occluded vessels were similar between the two groups. Patients with IHS received a higher number of active malignancy diagnoses, were more likely to withhold antithrombotic agents, and exhibited higher prestroke functional dependency. The median onset-to-puncture time was 192 min in IHS and 217 min in COS (P = 0.15). The percentages of successful recanalization (79% vs 71%), symptomatic hemorrhage (0% vs 9%), functional independence (42% vs 40%), and mortality (17% vs 12%) were comparable between the two groups. After adjustment for covariates, initial NIHSS scores and successful recanalization were the most important predictors for functional independence at 90 days. Conclusions Despite having disadvantages at baseline, patients with IHS could still benefit from timely EVT to achieve favorable outcomes. A well-designed acute stroke protocol tailored for IHS should be developed.

Original languageEnglish
Article numbere0214883
JournalPLoS ONE
Volume14
Issue number4
DOIs
Publication statusPublished - Apr 2019

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Thrombectomy
stroke
Stroke
Health
National Institutes of Health
Fibrinolytic Agents
National Institutes of Health (U.S.)
hemorrhage

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lu, M. Y., Chen, C. H., Yeh, S. J., Tsai, L. K., Lee, C. W., Tang, S. C., & Jeng, J. S. (2019). Comparison between in-hospital stroke and community-onset stroke treated with endovascular thrombectomy. PLoS ONE, 14(4), [e0214883]. https://doi.org/10.1371/journal.pone.0214883

Comparison between in-hospital stroke and community-onset stroke treated with endovascular thrombectomy. / Lu, Min Yi; Chen, Chih Hao; Yeh, Shin Joe; Tsai, Li Kai; Lee, Chung Wei; Tang, Sung Chun; Jeng, Jiann Shing.

In: PLoS ONE, Vol. 14, No. 4, e0214883, 04.2019.

Research output: Contribution to journalArticle

Lu, Min Yi ; Chen, Chih Hao ; Yeh, Shin Joe ; Tsai, Li Kai ; Lee, Chung Wei ; Tang, Sung Chun ; Jeng, Jiann Shing. / Comparison between in-hospital stroke and community-onset stroke treated with endovascular thrombectomy. In: PLoS ONE. 2019 ; Vol. 14, No. 4.
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