Comparison between botulinum toxin type A injection and selective posterior rhizotomy in improving gait performance in children with cerebral palsy

Alice M K Wong, Yu Cheng Pei, Tai Ngar Lui, Chia Ling Chen, Chin Man Wang, Chia Ying Chung

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Object. Both botulinum toxin type A (BTA) injection and selective posterior rhizotomy (SPR) are well-recognized treatments for children with spastic cerebral palsy (CP); however, there has been no study in which the long-term effectiveness of these two approaches has been compared. Methods. The study population comprised 62 ambulatory children with spastic diplegic CP who were participating in the same rehabilitation program and 19 healthy volunteers. The children with CP were divided into the following three groups: BTA (22 cases), SPR (20 cases), and no treatment (20 cases); the healthy volunteers served as the control group. A computer-assisted gait analysis system was used to assess gait performance. Gait was assessed in the three groups of children at 1 week before treatment, and 3, 6, 12, and 20 months after treatment. Based on the analysis of walking velocity, cadence, and step length, the BTA group demonstrated rapid improvement posttreatment but the improvement became insignificant after 12 months even with repeated BTA injections at 4-month intervals. In contrast, the SPR group displayed initial deterioration of gait parameters during the first 3 months posttreatment and then improved continuously from 6 to 20 months. The control group did not display a significant change in gait. Conclusions. The findings suggest that the effectiveness of BTA injection is more short-lived and SPR initially decreases gait performance but is expected to improve gait performance at between 6 and 20 months after the procedure.

Original languageEnglish
Pages (from-to)385-389
Number of pages5
JournalJournal of Neurosurgery
Volume102 PEDIATRICS
Issue numberSUPPL. 4
Publication statusPublished - May 2005
Externally publishedYes

Fingerprint

Rhizotomy
Type A Botulinum Toxins
Cerebral Palsy
Gait
Injections
Healthy Volunteers
Control Groups
Therapeutics
Walking
Rehabilitation

Keywords

  • Botulinum toxin
  • Cerebral palsy
  • Gait
  • Pediatric neurosurgery
  • Rhizotomy
  • Spasticity

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Wong, A. M. K., Pei, Y. C., Lui, T. N., Chen, C. L., Wang, C. M., & Chung, C. Y. (2005). Comparison between botulinum toxin type A injection and selective posterior rhizotomy in improving gait performance in children with cerebral palsy. Journal of Neurosurgery, 102 PEDIATRICS(SUPPL. 4), 385-389.

Comparison between botulinum toxin type A injection and selective posterior rhizotomy in improving gait performance in children with cerebral palsy. / Wong, Alice M K; Pei, Yu Cheng; Lui, Tai Ngar; Chen, Chia Ling; Wang, Chin Man; Chung, Chia Ying.

In: Journal of Neurosurgery, Vol. 102 PEDIATRICS, No. SUPPL. 4, 05.2005, p. 385-389.

Research output: Contribution to journalArticle

Wong, AMK, Pei, YC, Lui, TN, Chen, CL, Wang, CM & Chung, CY 2005, 'Comparison between botulinum toxin type A injection and selective posterior rhizotomy in improving gait performance in children with cerebral palsy', Journal of Neurosurgery, vol. 102 PEDIATRICS, no. SUPPL. 4, pp. 385-389.
Wong, Alice M K ; Pei, Yu Cheng ; Lui, Tai Ngar ; Chen, Chia Ling ; Wang, Chin Man ; Chung, Chia Ying. / Comparison between botulinum toxin type A injection and selective posterior rhizotomy in improving gait performance in children with cerebral palsy. In: Journal of Neurosurgery. 2005 ; Vol. 102 PEDIATRICS, No. SUPPL. 4. pp. 385-389.
@article{807270a1092247019ddbe2009587c338,
title = "Comparison between botulinum toxin type A injection and selective posterior rhizotomy in improving gait performance in children with cerebral palsy",
abstract = "Object. Both botulinum toxin type A (BTA) injection and selective posterior rhizotomy (SPR) are well-recognized treatments for children with spastic cerebral palsy (CP); however, there has been no study in which the long-term effectiveness of these two approaches has been compared. Methods. The study population comprised 62 ambulatory children with spastic diplegic CP who were participating in the same rehabilitation program and 19 healthy volunteers. The children with CP were divided into the following three groups: BTA (22 cases), SPR (20 cases), and no treatment (20 cases); the healthy volunteers served as the control group. A computer-assisted gait analysis system was used to assess gait performance. Gait was assessed in the three groups of children at 1 week before treatment, and 3, 6, 12, and 20 months after treatment. Based on the analysis of walking velocity, cadence, and step length, the BTA group demonstrated rapid improvement posttreatment but the improvement became insignificant after 12 months even with repeated BTA injections at 4-month intervals. In contrast, the SPR group displayed initial deterioration of gait parameters during the first 3 months posttreatment and then improved continuously from 6 to 20 months. The control group did not display a significant change in gait. Conclusions. The findings suggest that the effectiveness of BTA injection is more short-lived and SPR initially decreases gait performance but is expected to improve gait performance at between 6 and 20 months after the procedure.",
keywords = "Botulinum toxin, Cerebral palsy, Gait, Pediatric neurosurgery, Rhizotomy, Spasticity",
author = "Wong, {Alice M K} and Pei, {Yu Cheng} and Lui, {Tai Ngar} and Chen, {Chia Ling} and Wang, {Chin Man} and Chung, {Chia Ying}",
year = "2005",
month = "5",
language = "English",
volume = "102 PEDIATRICS",
pages = "385--389",
journal = "Journal of Neurosurgery",
issn = "0022-3085",
publisher = "American Association of Neurological Surgeons",
number = "SUPPL. 4",

}

TY - JOUR

T1 - Comparison between botulinum toxin type A injection and selective posterior rhizotomy in improving gait performance in children with cerebral palsy

AU - Wong, Alice M K

AU - Pei, Yu Cheng

AU - Lui, Tai Ngar

AU - Chen, Chia Ling

AU - Wang, Chin Man

AU - Chung, Chia Ying

PY - 2005/5

Y1 - 2005/5

N2 - Object. Both botulinum toxin type A (BTA) injection and selective posterior rhizotomy (SPR) are well-recognized treatments for children with spastic cerebral palsy (CP); however, there has been no study in which the long-term effectiveness of these two approaches has been compared. Methods. The study population comprised 62 ambulatory children with spastic diplegic CP who were participating in the same rehabilitation program and 19 healthy volunteers. The children with CP were divided into the following three groups: BTA (22 cases), SPR (20 cases), and no treatment (20 cases); the healthy volunteers served as the control group. A computer-assisted gait analysis system was used to assess gait performance. Gait was assessed in the three groups of children at 1 week before treatment, and 3, 6, 12, and 20 months after treatment. Based on the analysis of walking velocity, cadence, and step length, the BTA group demonstrated rapid improvement posttreatment but the improvement became insignificant after 12 months even with repeated BTA injections at 4-month intervals. In contrast, the SPR group displayed initial deterioration of gait parameters during the first 3 months posttreatment and then improved continuously from 6 to 20 months. The control group did not display a significant change in gait. Conclusions. The findings suggest that the effectiveness of BTA injection is more short-lived and SPR initially decreases gait performance but is expected to improve gait performance at between 6 and 20 months after the procedure.

AB - Object. Both botulinum toxin type A (BTA) injection and selective posterior rhizotomy (SPR) are well-recognized treatments for children with spastic cerebral palsy (CP); however, there has been no study in which the long-term effectiveness of these two approaches has been compared. Methods. The study population comprised 62 ambulatory children with spastic diplegic CP who were participating in the same rehabilitation program and 19 healthy volunteers. The children with CP were divided into the following three groups: BTA (22 cases), SPR (20 cases), and no treatment (20 cases); the healthy volunteers served as the control group. A computer-assisted gait analysis system was used to assess gait performance. Gait was assessed in the three groups of children at 1 week before treatment, and 3, 6, 12, and 20 months after treatment. Based on the analysis of walking velocity, cadence, and step length, the BTA group demonstrated rapid improvement posttreatment but the improvement became insignificant after 12 months even with repeated BTA injections at 4-month intervals. In contrast, the SPR group displayed initial deterioration of gait parameters during the first 3 months posttreatment and then improved continuously from 6 to 20 months. The control group did not display a significant change in gait. Conclusions. The findings suggest that the effectiveness of BTA injection is more short-lived and SPR initially decreases gait performance but is expected to improve gait performance at between 6 and 20 months after the procedure.

KW - Botulinum toxin

KW - Cerebral palsy

KW - Gait

KW - Pediatric neurosurgery

KW - Rhizotomy

KW - Spasticity

UR - http://www.scopus.com/inward/record.url?scp=20344388322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20344388322&partnerID=8YFLogxK

M3 - Article

VL - 102 PEDIATRICS

SP - 385

EP - 389

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

SN - 0022-3085

IS - SUPPL. 4

ER -