Comparing the Relationship of Taxol-Based Chemotherapy Response with P-glycoprotein and Lung Resistance-Related Protein Expression in Non-Small Cell Lung Cancer

J. F. Chiou, J. A. Liang, W. H. Hsu, J. J. Wang, S. T. Ho, A. Kao

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Our aim was to compare Taxol-based chemotherapy response of non-small cell lung cancer (NSCLC) with P-glycoprotein (Pgp) or lung resistance protein expression (LRP). Immunohistochemical analyses were performed on multiple nonconsecutive sections of the biopsy specimens to detect Pgp and LPR expressions in 40 patients with advanced NSCLC before Taxol-based chemotherapy. The chemotherapy response was evaluated by clinical and radiological methods in the third month after completion of treatment. No significant differences of prognostic factors (age, sex, body weight loss, performance status, tumor size, tumor stage, and tumor cell type) were found between the 20 patients with good and the 20 patients with poor responses. The incidence difference of positive Pgp expressions between good and poor responses wat.s significant, however, the difference of LRP expression was no We concluded that Taxol-based chemotherapy response of patients with NSCLC was related to Pgp but not LPR expression.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalLung
Volume181
Issue number5
DOIs
Publication statusPublished - 2003

Fingerprint

P-Glycoprotein
Paclitaxel
Non-Small Cell Lung Carcinoma
Drug Therapy
Neoplasms
Weight Loss
Body Weight
Biopsy
major vault protein
Incidence
Therapeutics

Keywords

  • Lung resistance protein expression
  • Non-small cell lung cancer
  • P-glycoprotein
  • Taxol

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Comparing the Relationship of Taxol-Based Chemotherapy Response with P-glycoprotein and Lung Resistance-Related Protein Expression in Non-Small Cell Lung Cancer. / Chiou, J. F.; Liang, J. A.; Hsu, W. H.; Wang, J. J.; Ho, S. T.; Kao, A.

In: Lung, Vol. 181, No. 5, 2003, p. 267-273.

Research output: Contribution to journalArticle

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