Comparing Stereotactic Body Radiotherapy with Three-Dimensional Conformal Radiotherapy for Patients with Unresectable or Recurrent Hepatocellular Carcinoma

Jang-Chun Lin, Yee Min Jen, Wen Yen Huang, Chang Min Chen, Hsing-Luog Chao, Chun Shun Lin, Yu Fu Su, Kuen Tze Lin, Chao Yueh Fan, Wei-Yuan Nien, Miao-Jung Lin

Research output: Contribution to journalArticle

Abstract

Purpose: To compare stereotactic body radiotherapy (SBRT) with three-dimensional conformal radiotherapy (3D-CRT) for improving hepatocellullar carcimona (HCC) patient survival rates.Material and Method: Forty-one patients with unresectable or recurrent HCC were divided into one group of 20 patients who received SBRT, and another group of 21 patients who received 3D-CRT. They were treated in the Radiation Oncology Department of the Tri-Service General Hospital from March 2007 to March 2009. The median follow-up time for all patients was 12 months (range 2 to 36 months). Overall survival was the primary end point.Results: For the 3D-CRT and SBRT patient groups, the median survival (MS) was 11 months and 16 months with the 1-year overall survival (OS) of 42.9% and 70.0%, respectively. In the univariate analysis, CyberKnife SBRT (p= 0.019), non-advanced Okuda stage (p= 0.002), serum albumin higher than 3.5g /dl (p= 0.008), and total bilirubin lower than 2.0 mg/dL (p= 0.042) were associated with significantly better OS. Further statistical analyses showed that those patients in Child-Pugh class A who received SBRT had better OS than those who received 3D-CRT (p= 0.047). Multivariate analyses revealed that Okuda stage (p= 0.006). Child-Pugh class (p= 0.042) and technique of RT (p= 0.029) were significant prognostic factors for OS.Conclusions: This study showed that patients who received SBRT had significantly better OS than those who received 3D-CRT. SBRT has the advantage of short overall treatment times compared to 3D-CRT. Our results also suggest that SBRT could be considered first in patients with Child-Pugh class A. Further study is required to define the effects of administered radiation dose and fractionation.
Translated title of the contribution針對無法切除或復發的肝癌病患比較立體定位放射治療及三度空間順形放射治療
Original languageEnglish
Pages (from-to)105-117
Number of pages13
Journal放射治療與腫瘤學
Volume19
Issue number2
DOIs
Publication statusPublished - Jun 1 2012
Externally publishedYes

Keywords

  • HCC
  • Stereotactic body radiotherapy
  • Three-Dimensional conlormal radiotherapy

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