Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in juvenile rheumatoid arthritis

Ju Fang Wu, Yao Hsu Yang, Li Chieh Wang, Jyh Hong Lee, Ein Yiao Shen, Bor Luen Chiang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective. To compare serial C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels in juvenile rheumatoid arthritis (JRA) patients and investigate their application as diagnostic parameters and prognostic predictive factors. Methods. We carried out retrospective chart review among JRA patients who were followed-up at the National Taiwan University Hospital (NTUH) between 1994 and 2005. Results. Thirty-nine girls and 68 boys were included in this study. At the time of diagnosis, the prevalence of ESR was significantly greater than that of CRP (86.8% vs. 47.2%, p <0.05). ESR revealed more responsiveness to treatment compared to CRP (SRMs were -0.69 and -0.31, respectively). At the time of diagnosis, high CRP levels (≥ 5mg/dL) correlated with poor therapeutic response, as do positive CRP (>0.8 mg/dL) and high ESR levels (>40 mm/h) after treatment for six months. Overall, initial high CRP levels (≥ 5mg/dL) demonstrated the strongest predictive role of failure of the first remission. Conclusions. For disease diagnosis, ESR can be a better parameter than CRP but a high initial CRP level can strongly predict treatment failure of the first remission.

Original languageEnglish
Pages (from-to)782-785
Number of pages4
JournalClinical and Experimental Rheumatology
Volume25
Issue number5
Publication statusPublished - Sep 2007

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Juvenile Arthritis
Blood Sedimentation
C-Reactive Protein
Treatment Failure
Taiwan

Keywords

  • C-reactive protein
  • Erythrocyte sedimentation rate
  • Juvenile rheumatoid arthitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wu, J. F., Yang, Y. H., Wang, L. C., Lee, J. H., Shen, E. Y., & Chiang, B. L. (2007). Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in juvenile rheumatoid arthritis. Clinical and Experimental Rheumatology, 25(5), 782-785.

Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in juvenile rheumatoid arthritis. / Wu, Ju Fang; Yang, Yao Hsu; Wang, Li Chieh; Lee, Jyh Hong; Shen, Ein Yiao; Chiang, Bor Luen.

In: Clinical and Experimental Rheumatology, Vol. 25, No. 5, 09.2007, p. 782-785.

Research output: Contribution to journalArticle

Wu, Ju Fang ; Yang, Yao Hsu ; Wang, Li Chieh ; Lee, Jyh Hong ; Shen, Ein Yiao ; Chiang, Bor Luen. / Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in juvenile rheumatoid arthritis. In: Clinical and Experimental Rheumatology. 2007 ; Vol. 25, No. 5. pp. 782-785.
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AU - Chiang, Bor Luen

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N2 - Objective. To compare serial C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels in juvenile rheumatoid arthritis (JRA) patients and investigate their application as diagnostic parameters and prognostic predictive factors. Methods. We carried out retrospective chart review among JRA patients who were followed-up at the National Taiwan University Hospital (NTUH) between 1994 and 2005. Results. Thirty-nine girls and 68 boys were included in this study. At the time of diagnosis, the prevalence of ESR was significantly greater than that of CRP (86.8% vs. 47.2%, p <0.05). ESR revealed more responsiveness to treatment compared to CRP (SRMs were -0.69 and -0.31, respectively). At the time of diagnosis, high CRP levels (≥ 5mg/dL) correlated with poor therapeutic response, as do positive CRP (>0.8 mg/dL) and high ESR levels (>40 mm/h) after treatment for six months. Overall, initial high CRP levels (≥ 5mg/dL) demonstrated the strongest predictive role of failure of the first remission. Conclusions. For disease diagnosis, ESR can be a better parameter than CRP but a high initial CRP level can strongly predict treatment failure of the first remission.

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