Abstract
Objective. To compare serial C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels in juvenile rheumatoid arthritis (JRA) patients and investigate their application as diagnostic parameters and prognostic predictive factors. Methods. We carried out retrospective chart review among JRA patients who were followed-up at the National Taiwan University Hospital (NTUH) between 1994 and 2005. Results. Thirty-nine girls and 68 boys were included in this study. At the time of diagnosis, the prevalence of ESR was significantly greater than that of CRP (86.8% vs. 47.2%, p <0.05). ESR revealed more responsiveness to treatment compared to CRP (SRMs were -0.69 and -0.31, respectively). At the time of diagnosis, high CRP levels (≥ 5mg/dL) correlated with poor therapeutic response, as do positive CRP (>0.8 mg/dL) and high ESR levels (>40 mm/h) after treatment for six months. Overall, initial high CRP levels (≥ 5mg/dL) demonstrated the strongest predictive role of failure of the first remission. Conclusions. For disease diagnosis, ESR can be a better parameter than CRP but a high initial CRP level can strongly predict treatment failure of the first remission.
| Original language | English |
|---|---|
| Pages (from-to) | 782-785 |
| Number of pages | 4 |
| Journal | Clinical and Experimental Rheumatology |
| Volume | 25 |
| Issue number | 5 |
| Publication status | Published - Sep 2007 |
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Keywords
- C-reactive protein
- Erythrocyte sedimentation rate
- Juvenile rheumatoid arthitis
ASJC Scopus subject areas
- Medicine(all)
Cite this
Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in juvenile rheumatoid arthritis. / Wu, Ju Fang; Yang, Yao Hsu; Wang, Li Chieh; Lee, Jyh Hong; Shen, Ein Yiao; Chiang, Bor Luen.
In: Clinical and Experimental Rheumatology, Vol. 25, No. 5, 09.2007, p. 782-785.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in juvenile rheumatoid arthritis
AU - Wu, Ju Fang
AU - Yang, Yao Hsu
AU - Wang, Li Chieh
AU - Lee, Jyh Hong
AU - Shen, Ein Yiao
AU - Chiang, Bor Luen
PY - 2007/9
Y1 - 2007/9
N2 - Objective. To compare serial C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels in juvenile rheumatoid arthritis (JRA) patients and investigate their application as diagnostic parameters and prognostic predictive factors. Methods. We carried out retrospective chart review among JRA patients who were followed-up at the National Taiwan University Hospital (NTUH) between 1994 and 2005. Results. Thirty-nine girls and 68 boys were included in this study. At the time of diagnosis, the prevalence of ESR was significantly greater than that of CRP (86.8% vs. 47.2%, p <0.05). ESR revealed more responsiveness to treatment compared to CRP (SRMs were -0.69 and -0.31, respectively). At the time of diagnosis, high CRP levels (≥ 5mg/dL) correlated with poor therapeutic response, as do positive CRP (>0.8 mg/dL) and high ESR levels (>40 mm/h) after treatment for six months. Overall, initial high CRP levels (≥ 5mg/dL) demonstrated the strongest predictive role of failure of the first remission. Conclusions. For disease diagnosis, ESR can be a better parameter than CRP but a high initial CRP level can strongly predict treatment failure of the first remission.
AB - Objective. To compare serial C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels in juvenile rheumatoid arthritis (JRA) patients and investigate their application as diagnostic parameters and prognostic predictive factors. Methods. We carried out retrospective chart review among JRA patients who were followed-up at the National Taiwan University Hospital (NTUH) between 1994 and 2005. Results. Thirty-nine girls and 68 boys were included in this study. At the time of diagnosis, the prevalence of ESR was significantly greater than that of CRP (86.8% vs. 47.2%, p <0.05). ESR revealed more responsiveness to treatment compared to CRP (SRMs were -0.69 and -0.31, respectively). At the time of diagnosis, high CRP levels (≥ 5mg/dL) correlated with poor therapeutic response, as do positive CRP (>0.8 mg/dL) and high ESR levels (>40 mm/h) after treatment for six months. Overall, initial high CRP levels (≥ 5mg/dL) demonstrated the strongest predictive role of failure of the first remission. Conclusions. For disease diagnosis, ESR can be a better parameter than CRP but a high initial CRP level can strongly predict treatment failure of the first remission.
KW - C-reactive protein
KW - Erythrocyte sedimentation rate
KW - Juvenile rheumatoid arthitis
UR - http://www.scopus.com/inward/record.url?scp=37349093731&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37349093731&partnerID=8YFLogxK
M3 - Article
C2 - 18078633
AN - SCOPUS:37349093731
VL - 25
SP - 782
EP - 785
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 5
ER -