Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas

Chun Ta Liao, Yu Wen Wen, Lan Yan Yang, Shu Ru Lee, Shu Hang Ng, Tsang Wu Liu, Sen Tien Tsai, Ming Hsui Tsai, Jin Ching Lin, Peir Rong Chen, Pei Jen Lou, Cheng Ping Wang, Pen Yuan Chu, Tzer Zen Hwang, Yi Shing Leu, Kuo Yang Tsai, Shyuang Der Terng, Tsung-Ming Chen, Cheng Hsu Wang, Chih Yen ChienWen Cheng Chen, Li Yu Lee, Chien Yu Lin, Hung Ming Wang, Chia Hsun Hsieh, Chung Kan Tsao, Tuan Jen Fang, Shiang Fu Huang, Chung Jan Kang, Kai Ping Chang, Tzu Chen Yen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives Although patients with buccal squamous cell carcinoma (SCC) usually show acceptable outcomes, local control and survival rates are generally lower than those observed for tongue SCC. This study was designed to compare the clinical outcomes of Taiwanese patients with these two common oral cavity malignancies. Methods Patients with first primary buccal or tongue SCC who were included in the Taiwanese Cancer Registry Database between 2004 and 2012 were eligible. The study sample consisted of 16,379 patients (7870 buccal SCC and 8509 tongue SCC) who received surgery with or without adjuvant therapy. The 5-year disease-specific survival (DSS) and overall survival (OS) rates served as the outcome measures. Results Compared with tongue SCC, patients with buccal SCC had a higher prevalence of males (95.7% vs. 86.4%, p < 0.0001), pT4 disease (21.4% vs. 12.7%, p < 0.0001), and p-Stage IV (30.4% vs. 24.8%, p < 0.0001) but a lower frequency of pN2 disease (15.2% vs. 18.5%, p < 0.0001). The 5-year DSS and OS rates of buccal SCC patients were slightly higher than those of tongue SCC (78% vs. 77%, p = 0.0297; and 71% vs. 69%, p = 0.0231, respectively). Multivariate analysis identified tumor site (tongue vs. buccal SCC), sex (male vs. female), age (≥65 vs. <65 years), pT classification (T4/T3/T2 vs. T1), and pN classification (N3/N2/N1 vs. N0) as independent prognostic factors in the entire study cohort. Conclusions The survival advantage of buccal SCC over tongue SCC appears significant in large clinical samples, despite a higher prevalence of p-Stage IV disease in the former.

Original languageEnglish
Pages (from-to)95-102
Number of pages8
JournalOral Oncology
Volume67
DOIs
Publication statusPublished - Apr 1 2017

Keywords

  • Buccal mucosa
  • Cancer Registry
  • Prognosis
  • Squamous cell carcinoma
  • Tongue

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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    Liao, C. T., Wen, Y. W., Yang, L. Y., Lee, S. R., Ng, S. H., Liu, T. W., Tsai, S. T., Tsai, M. H., Lin, J. C., Chen, P. R., Lou, P. J., Wang, C. P., Chu, P. Y., Hwang, T. Z., Leu, Y. S., Tsai, K. Y., Terng, S. D., Chen, T-M., Wang, C. H., ... Yen, T. C. (2017). Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas. Oral Oncology, 67, 95-102. https://doi.org/10.1016/j.oraloncology.2017.02.011