Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas

Chun Ta Liao, Yu Wen Wen, Lan Yan Yang, Shu Ru Lee, Shu Hang Ng, Tsang Wu Liu, Sen Tien Tsai, Ming Hsui Tsai, Jin Ching Lin, Peir Rong Chen, Pei Jen Lou, Cheng Ping Wang, Pen Yuan Chu, Tzer Zen Hwang, Yi Shing Leu, Kuo Yang Tsai, Shyuang Der Terng, Tsung-Ming Chen, Cheng Hsu Wang, Chih Yen ChienWen Cheng Chen, Li Yu Lee, Chien Yu Lin, Hung Ming Wang, Chia Hsun Hsieh, Chung Kan Tsao, Tuan Jen Fang, Shiang Fu Huang, Chung Jan Kang, Kai Ping Chang, Tzu Chen Yen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives Although patients with buccal squamous cell carcinoma (SCC) usually show acceptable outcomes, local control and survival rates are generally lower than those observed for tongue SCC. This study was designed to compare the clinical outcomes of Taiwanese patients with these two common oral cavity malignancies. Methods Patients with first primary buccal or tongue SCC who were included in the Taiwanese Cancer Registry Database between 2004 and 2012 were eligible. The study sample consisted of 16,379 patients (7870 buccal SCC and 8509 tongue SCC) who received surgery with or without adjuvant therapy. The 5-year disease-specific survival (DSS) and overall survival (OS) rates served as the outcome measures. Results Compared with tongue SCC, patients with buccal SCC had a higher prevalence of males (95.7% vs. 86.4%, p < 0.0001), pT4 disease (21.4% vs. 12.7%, p < 0.0001), and p-Stage IV (30.4% vs. 24.8%, p < 0.0001) but a lower frequency of pN2 disease (15.2% vs. 18.5%, p < 0.0001). The 5-year DSS and OS rates of buccal SCC patients were slightly higher than those of tongue SCC (78% vs. 77%, p = 0.0297; and 71% vs. 69%, p = 0.0231, respectively). Multivariate analysis identified tumor site (tongue vs. buccal SCC), sex (male vs. female), age (≥65 vs. <65 years), pT classification (T4/T3/T2 vs. T1), and pN classification (N3/N2/N1 vs. N0) as independent prognostic factors in the entire study cohort. Conclusions The survival advantage of buccal SCC over tongue SCC appears significant in large clinical samples, despite a higher prevalence of p-Stage IV disease in the former.

Original languageEnglish
Pages (from-to)95-102
Number of pages8
JournalOral Oncology
Volume67
DOIs
Publication statusPublished - Apr 1 2017

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Cheek
Tongue
Squamous Cell Carcinoma
Survival Rate
Survival
Neoplasms
Registries
Mouth
Cohort Studies
Multivariate Analysis
Outcome Assessment (Health Care)
Databases

Keywords

  • Buccal mucosa
  • Cancer Registry
  • Prognosis
  • Squamous cell carcinoma
  • Tongue

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas. / Liao, Chun Ta; Wen, Yu Wen; Yang, Lan Yan; Lee, Shu Ru; Ng, Shu Hang; Liu, Tsang Wu; Tsai, Sen Tien; Tsai, Ming Hsui; Lin, Jin Ching; Chen, Peir Rong; Lou, Pei Jen; Wang, Cheng Ping; Chu, Pen Yuan; Hwang, Tzer Zen; Leu, Yi Shing; Tsai, Kuo Yang; Terng, Shyuang Der; Chen, Tsung-Ming; Wang, Cheng Hsu; Chien, Chih Yen; Chen, Wen Cheng; Lee, Li Yu; Lin, Chien Yu; Wang, Hung Ming; Hsieh, Chia Hsun; Tsao, Chung Kan; Fang, Tuan Jen; Huang, Shiang Fu; Kang, Chung Jan; Chang, Kai Ping; Yen, Tzu Chen.

In: Oral Oncology, Vol. 67, 01.04.2017, p. 95-102.

Research output: Contribution to journalArticle

Liao, CT, Wen, YW, Yang, LY, Lee, SR, Ng, SH, Liu, TW, Tsai, ST, Tsai, MH, Lin, JC, Chen, PR, Lou, PJ, Wang, CP, Chu, PY, Hwang, TZ, Leu, YS, Tsai, KY, Terng, SD, Chen, T-M, Wang, CH, Chien, CY, Chen, WC, Lee, LY, Lin, CY, Wang, HM, Hsieh, CH, Tsao, CK, Fang, TJ, Huang, SF, Kang, CJ, Chang, KP & Yen, TC 2017, 'Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas', Oral Oncology, vol. 67, pp. 95-102. https://doi.org/10.1016/j.oraloncology.2017.02.011
Liao, Chun Ta ; Wen, Yu Wen ; Yang, Lan Yan ; Lee, Shu Ru ; Ng, Shu Hang ; Liu, Tsang Wu ; Tsai, Sen Tien ; Tsai, Ming Hsui ; Lin, Jin Ching ; Chen, Peir Rong ; Lou, Pei Jen ; Wang, Cheng Ping ; Chu, Pen Yuan ; Hwang, Tzer Zen ; Leu, Yi Shing ; Tsai, Kuo Yang ; Terng, Shyuang Der ; Chen, Tsung-Ming ; Wang, Cheng Hsu ; Chien, Chih Yen ; Chen, Wen Cheng ; Lee, Li Yu ; Lin, Chien Yu ; Wang, Hung Ming ; Hsieh, Chia Hsun ; Tsao, Chung Kan ; Fang, Tuan Jen ; Huang, Shiang Fu ; Kang, Chung Jan ; Chang, Kai Ping ; Yen, Tzu Chen. / Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas. In: Oral Oncology. 2017 ; Vol. 67. pp. 95-102.
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abstract = "Objectives Although patients with buccal squamous cell carcinoma (SCC) usually show acceptable outcomes, local control and survival rates are generally lower than those observed for tongue SCC. This study was designed to compare the clinical outcomes of Taiwanese patients with these two common oral cavity malignancies. Methods Patients with first primary buccal or tongue SCC who were included in the Taiwanese Cancer Registry Database between 2004 and 2012 were eligible. The study sample consisted of 16,379 patients (7870 buccal SCC and 8509 tongue SCC) who received surgery with or without adjuvant therapy. The 5-year disease-specific survival (DSS) and overall survival (OS) rates served as the outcome measures. Results Compared with tongue SCC, patients with buccal SCC had a higher prevalence of males (95.7{\%} vs. 86.4{\%}, p < 0.0001), pT4 disease (21.4{\%} vs. 12.7{\%}, p < 0.0001), and p-Stage IV (30.4{\%} vs. 24.8{\%}, p < 0.0001) but a lower frequency of pN2 disease (15.2{\%} vs. 18.5{\%}, p < 0.0001). The 5-year DSS and OS rates of buccal SCC patients were slightly higher than those of tongue SCC (78{\%} vs. 77{\%}, p = 0.0297; and 71{\%} vs. 69{\%}, p = 0.0231, respectively). Multivariate analysis identified tumor site (tongue vs. buccal SCC), sex (male vs. female), age (≥65 vs. <65 years), pT classification (T4/T3/T2 vs. T1), and pN classification (N3/N2/N1 vs. N0) as independent prognostic factors in the entire study cohort. Conclusions The survival advantage of buccal SCC over tongue SCC appears significant in large clinical samples, despite a higher prevalence of p-Stage IV disease in the former.",
keywords = "Buccal mucosa, Cancer Registry, Prognosis, Squamous cell carcinoma, Tongue",
author = "Liao, {Chun Ta} and Wen, {Yu Wen} and Yang, {Lan Yan} and Lee, {Shu Ru} and Ng, {Shu Hang} and Liu, {Tsang Wu} and Tsai, {Sen Tien} and Tsai, {Ming Hsui} and Lin, {Jin Ching} and Chen, {Peir Rong} and Lou, {Pei Jen} and Wang, {Cheng Ping} and Chu, {Pen Yuan} and Hwang, {Tzer Zen} and Leu, {Yi Shing} and Tsai, {Kuo Yang} and Terng, {Shyuang Der} and Tsung-Ming Chen and Wang, {Cheng Hsu} and Chien, {Chih Yen} and Chen, {Wen Cheng} and Lee, {Li Yu} and Lin, {Chien Yu} and Wang, {Hung Ming} and Hsieh, {Chia Hsun} and Tsao, {Chung Kan} and Fang, {Tuan Jen} and Huang, {Shiang Fu} and Kang, {Chung Jan} and Chang, {Kai Ping} and Yen, {Tzu Chen}",
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T1 - Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas

AU - Liao, Chun Ta

AU - Wen, Yu Wen

AU - Yang, Lan Yan

AU - Lee, Shu Ru

AU - Ng, Shu Hang

AU - Liu, Tsang Wu

AU - Tsai, Sen Tien

AU - Tsai, Ming Hsui

AU - Lin, Jin Ching

AU - Chen, Peir Rong

AU - Lou, Pei Jen

AU - Wang, Cheng Ping

AU - Chu, Pen Yuan

AU - Hwang, Tzer Zen

AU - Leu, Yi Shing

AU - Tsai, Kuo Yang

AU - Terng, Shyuang Der

AU - Chen, Tsung-Ming

AU - Wang, Cheng Hsu

AU - Chien, Chih Yen

AU - Chen, Wen Cheng

AU - Lee, Li Yu

AU - Lin, Chien Yu

AU - Wang, Hung Ming

AU - Hsieh, Chia Hsun

AU - Tsao, Chung Kan

AU - Fang, Tuan Jen

AU - Huang, Shiang Fu

AU - Kang, Chung Jan

AU - Chang, Kai Ping

AU - Yen, Tzu Chen

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Objectives Although patients with buccal squamous cell carcinoma (SCC) usually show acceptable outcomes, local control and survival rates are generally lower than those observed for tongue SCC. This study was designed to compare the clinical outcomes of Taiwanese patients with these two common oral cavity malignancies. Methods Patients with first primary buccal or tongue SCC who were included in the Taiwanese Cancer Registry Database between 2004 and 2012 were eligible. The study sample consisted of 16,379 patients (7870 buccal SCC and 8509 tongue SCC) who received surgery with or without adjuvant therapy. The 5-year disease-specific survival (DSS) and overall survival (OS) rates served as the outcome measures. Results Compared with tongue SCC, patients with buccal SCC had a higher prevalence of males (95.7% vs. 86.4%, p < 0.0001), pT4 disease (21.4% vs. 12.7%, p < 0.0001), and p-Stage IV (30.4% vs. 24.8%, p < 0.0001) but a lower frequency of pN2 disease (15.2% vs. 18.5%, p < 0.0001). The 5-year DSS and OS rates of buccal SCC patients were slightly higher than those of tongue SCC (78% vs. 77%, p = 0.0297; and 71% vs. 69%, p = 0.0231, respectively). Multivariate analysis identified tumor site (tongue vs. buccal SCC), sex (male vs. female), age (≥65 vs. <65 years), pT classification (T4/T3/T2 vs. T1), and pN classification (N3/N2/N1 vs. N0) as independent prognostic factors in the entire study cohort. Conclusions The survival advantage of buccal SCC over tongue SCC appears significant in large clinical samples, despite a higher prevalence of p-Stage IV disease in the former.

AB - Objectives Although patients with buccal squamous cell carcinoma (SCC) usually show acceptable outcomes, local control and survival rates are generally lower than those observed for tongue SCC. This study was designed to compare the clinical outcomes of Taiwanese patients with these two common oral cavity malignancies. Methods Patients with first primary buccal or tongue SCC who were included in the Taiwanese Cancer Registry Database between 2004 and 2012 were eligible. The study sample consisted of 16,379 patients (7870 buccal SCC and 8509 tongue SCC) who received surgery with or without adjuvant therapy. The 5-year disease-specific survival (DSS) and overall survival (OS) rates served as the outcome measures. Results Compared with tongue SCC, patients with buccal SCC had a higher prevalence of males (95.7% vs. 86.4%, p < 0.0001), pT4 disease (21.4% vs. 12.7%, p < 0.0001), and p-Stage IV (30.4% vs. 24.8%, p < 0.0001) but a lower frequency of pN2 disease (15.2% vs. 18.5%, p < 0.0001). The 5-year DSS and OS rates of buccal SCC patients were slightly higher than those of tongue SCC (78% vs. 77%, p = 0.0297; and 71% vs. 69%, p = 0.0231, respectively). Multivariate analysis identified tumor site (tongue vs. buccal SCC), sex (male vs. female), age (≥65 vs. <65 years), pT classification (T4/T3/T2 vs. T1), and pN classification (N3/N2/N1 vs. N0) as independent prognostic factors in the entire study cohort. Conclusions The survival advantage of buccal SCC over tongue SCC appears significant in large clinical samples, despite a higher prevalence of p-Stage IV disease in the former.

KW - Buccal mucosa

KW - Cancer Registry

KW - Prognosis

KW - Squamous cell carcinoma

KW - Tongue

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