Companions reverse stressor-induced decreases in neurogenesis and cocaine conditioning possibly by restoring BDNF and NGF levels in dentate gyrus

Wen Yu Tzeng, Jia Ying Chuang, Li Ching Lin, Chianfang G. Cherng, Kuei Ying Lin, Li Hsien Chen, Chien Chou Su, Lung Yu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The presence of companions can reverse the stressor-induced decrease in neurogenesis in mouse dentate gyrus (DG). In this study, we decided to study the underlying mechanisms of the companions' protective effect and to assess whether two DG neurogenesis-related memories, cocaine-induced conditioned place preference (CPP) and spatial memory, can be affected by our stressor and companions. Neurotrophin levels in DG were measured, in this regard, to reveal their roles in mediating the stressors' and companions' effect. We found that the stressor did not affect NT-3 but acutely decreased NGF and BDNF levels in DG. The presence of companions abolished these stressor-decreased NGF and BDNF levels. Neither the stressor nor the presence of companions affected TrkA, TrkB or TrkC expression in DG. Pre-exposure to the stressor rendered deficits in cocaine-induced CPP and spatial memory, while companions reversed the stressor-decreased cocaine-induced CPP. Intra-ventricular infusion with K252a, a mixed TrkA and TrkB antagonist, did not affect the protective effects of companions on local NGF, BDNF levels in DG, but abolished the companions' protective effects against the stressor-decreased DG neurogenesis and cocaine-induced CPP. Systemic pretreatment with 7,8-dihydroxyflavone (DHF), a selective TrkB agonist, did not affect baseline, the stressor-stimulated corticosterone (CORT) secretion or local NGF, BDNF levels in DG, but in part mimicked companions' protective effects. These results, taken together, indicate that stressor-decreased NGF and BDNF levels in DG could be involved in the stressor-decreased DG neurogenesis and cocaine conditioning. The presence of companions reverses the stressor-decreased DG neurogenesis and cocaine conditioning possibly by restoring BDNF and NGF levels in DG.

Original languageEnglish
Pages (from-to)425-437
Number of pages13
JournalPsychoneuroendocrinology
Volume38
Issue number3
DOIs
Publication statusPublished - Mar 2013
Externally publishedYes

Fingerprint

Brain-Derived Neurotrophic Factor
Neurogenesis
Dentate Gyrus
Nerve Growth Factor
Cocaine
Conditioning (Psychology)
Nerve Growth Factors
Corticosterone

Keywords

  • BDNF
  • Cocaine
  • CORT
  • CPP
  • DG
  • DHF
  • Memory
  • Neurogenesis
  • Neurotrophins
  • NGF
  • NT-3
  • Social support
  • Stressor

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems

Cite this

Companions reverse stressor-induced decreases in neurogenesis and cocaine conditioning possibly by restoring BDNF and NGF levels in dentate gyrus. / Tzeng, Wen Yu; Chuang, Jia Ying; Lin, Li Ching; Cherng, Chianfang G.; Lin, Kuei Ying; Chen, Li Hsien; Su, Chien Chou; Yu, Lung.

In: Psychoneuroendocrinology, Vol. 38, No. 3, 03.2013, p. 425-437.

Research output: Contribution to journalArticle

Tzeng, Wen Yu ; Chuang, Jia Ying ; Lin, Li Ching ; Cherng, Chianfang G. ; Lin, Kuei Ying ; Chen, Li Hsien ; Su, Chien Chou ; Yu, Lung. / Companions reverse stressor-induced decreases in neurogenesis and cocaine conditioning possibly by restoring BDNF and NGF levels in dentate gyrus. In: Psychoneuroendocrinology. 2013 ; Vol. 38, No. 3. pp. 425-437.
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