Abstract

Background: Data regarding the wide spectrum of comorbidity amongst patients with multiple sclerosis (MS) are still scanty, especially in Asian populations. Our goal was to analyze comorbidity prevalences and risks amongst Chinese patients with MS, compared to matched controls. Methods: In total, 898 patients with MS and 4490 randomly matched individuals without MS were extracted from the National Health Insurance Research Dataset in Taiwan. We selected 30 comorbid medical conditions for analysis. Conditional logistic regression analyses were used to examine the risks of comorbidity between the two groups. Results: The regression analyses showed that patients with MS were more likely to have systemic lupus erythematosus (OR = 26.9, 95% CI = 10.3-70.3), depression (OR = 6.9, 95% CI = 5.3-8.9), peripheral vascular disorders (OR = 6.6, 95% CI = 4.0-11.0), deficiency anemias (OR = 4.9, 95% CI = 2.8-8.7), rheumatoid arthritis (OR = 4.8, 95% CI = 2.9-8.1) and fluid and electrolyte disorders (OR = 4.8, 95% CI = 2.8-8.3) than the matched controls. Conclusions: Patients with MS had higher risk of multiple medical comorbidities compared to a matched control group in an ethnic Chinese population.

Original languageEnglish
Pages (from-to)1215-1219
Number of pages5
JournalEuropean Journal of Neurology
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Multiple Sclerosis
Comorbidity
Population
Regression Analysis
National Health Programs
Taiwan
Systemic Lupus Erythematosus
Electrolytes
Blood Vessels
Anemia
Rheumatoid Arthritis
Research Design
Logistic Models
Control Groups
Research

Keywords

  • comorbidities
  • ethnic Chinese
  • multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

@article{8de2a75af67640fe8c2005f6ae03e955,
title = "Comorbidities amongst patients with multiple sclerosis: A population-based controlled study",
abstract = "Background: Data regarding the wide spectrum of comorbidity amongst patients with multiple sclerosis (MS) are still scanty, especially in Asian populations. Our goal was to analyze comorbidity prevalences and risks amongst Chinese patients with MS, compared to matched controls. Methods: In total, 898 patients with MS and 4490 randomly matched individuals without MS were extracted from the National Health Insurance Research Dataset in Taiwan. We selected 30 comorbid medical conditions for analysis. Conditional logistic regression analyses were used to examine the risks of comorbidity between the two groups. Results: The regression analyses showed that patients with MS were more likely to have systemic lupus erythematosus (OR = 26.9, 95{\%} CI = 10.3-70.3), depression (OR = 6.9, 95{\%} CI = 5.3-8.9), peripheral vascular disorders (OR = 6.6, 95{\%} CI = 4.0-11.0), deficiency anemias (OR = 4.9, 95{\%} CI = 2.8-8.7), rheumatoid arthritis (OR = 4.8, 95{\%} CI = 2.9-8.1) and fluid and electrolyte disorders (OR = 4.8, 95{\%} CI = 2.8-8.3) than the matched controls. Conclusions: Patients with MS had higher risk of multiple medical comorbidities compared to a matched control group in an ethnic Chinese population.",
keywords = "comorbidities, ethnic Chinese, multiple sclerosis",
author = "Kang, {J. H.} and Chen, {Y. H.} and Lin, {H. C.}",
year = "2010",
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volume = "17",
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TY - JOUR

T1 - Comorbidities amongst patients with multiple sclerosis

T2 - A population-based controlled study

AU - Kang, J. H.

AU - Chen, Y. H.

AU - Lin, H. C.

PY - 2010/9

Y1 - 2010/9

N2 - Background: Data regarding the wide spectrum of comorbidity amongst patients with multiple sclerosis (MS) are still scanty, especially in Asian populations. Our goal was to analyze comorbidity prevalences and risks amongst Chinese patients with MS, compared to matched controls. Methods: In total, 898 patients with MS and 4490 randomly matched individuals without MS were extracted from the National Health Insurance Research Dataset in Taiwan. We selected 30 comorbid medical conditions for analysis. Conditional logistic regression analyses were used to examine the risks of comorbidity between the two groups. Results: The regression analyses showed that patients with MS were more likely to have systemic lupus erythematosus (OR = 26.9, 95% CI = 10.3-70.3), depression (OR = 6.9, 95% CI = 5.3-8.9), peripheral vascular disorders (OR = 6.6, 95% CI = 4.0-11.0), deficiency anemias (OR = 4.9, 95% CI = 2.8-8.7), rheumatoid arthritis (OR = 4.8, 95% CI = 2.9-8.1) and fluid and electrolyte disorders (OR = 4.8, 95% CI = 2.8-8.3) than the matched controls. Conclusions: Patients with MS had higher risk of multiple medical comorbidities compared to a matched control group in an ethnic Chinese population.

AB - Background: Data regarding the wide spectrum of comorbidity amongst patients with multiple sclerosis (MS) are still scanty, especially in Asian populations. Our goal was to analyze comorbidity prevalences and risks amongst Chinese patients with MS, compared to matched controls. Methods: In total, 898 patients with MS and 4490 randomly matched individuals without MS were extracted from the National Health Insurance Research Dataset in Taiwan. We selected 30 comorbid medical conditions for analysis. Conditional logistic regression analyses were used to examine the risks of comorbidity between the two groups. Results: The regression analyses showed that patients with MS were more likely to have systemic lupus erythematosus (OR = 26.9, 95% CI = 10.3-70.3), depression (OR = 6.9, 95% CI = 5.3-8.9), peripheral vascular disorders (OR = 6.6, 95% CI = 4.0-11.0), deficiency anemias (OR = 4.9, 95% CI = 2.8-8.7), rheumatoid arthritis (OR = 4.8, 95% CI = 2.9-8.1) and fluid and electrolyte disorders (OR = 4.8, 95% CI = 2.8-8.3) than the matched controls. Conclusions: Patients with MS had higher risk of multiple medical comorbidities compared to a matched control group in an ethnic Chinese population.

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