Community-based molecular epidemiology of HTLV type I in Taiwan and Kinmen: Implication of the origin of the cosmopolitan subtype in northeast Asia

Yi Ming A. Chen, Sing Tho Ting, Cheng Ming Lee, Wu Tse Liu, Wen Harn Pan, Andrew T.A. Cheng, Pesus Chou

Research output: Contribution to journalArticle

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Abstract

To understand the possible origin and dissemination of HTLV-I infection in northeast Asia, community-based molecular epidemiological studies were conducted on the Kinmen Islands (off the coast of Fukien Province, China) and in Taiwan. A total of 3831 Taiwanese from 3 townships (Pu-Li, Chu-Dung, and Pu-Tze) and 993 aborigines from 4 tribes in Taiwan participated in this study. The prevalence rates of HTLV-I infection in adult residents from Pu- Li, Chu-Dung, and Pu-Tze were 0.82, 1.72, and 1.63%, respectively. None of the aborigines had HTLV-I infection. Previously, 0.73% of the adult population of Kin-Hu, Kinmen were found to have HTLV-I infection. Peripheral blood mononuclear cells were collected from HTLV-I carriers identified both in Taiwan and Kinmen and the HTLV-I LTR sequences were PCR amplified, subcloned, and sequenced for phylogenetic tree analysis. The results showed that all 6 HTLV-I isolates from Kinmen and 13 of 18 (72.2%) isolates from Taiwan were group a (transcontinental) of Cosmopolitan subtype, while 5 of 18 (27.8%) isolates from Taiwan were group b (Japanese) of Cosmopolitan subtype. Since all of the HTLV-I-infected persons were descendants of immigrants from mainland China, the origin of the Cosmopolitan subtype in Taiwan and Kinmen may not have been Japan, as previously theorized, but China, possibly the result of the migration of an infected population in the past several centuries.

Original languageEnglish
Pages (from-to)229-237
Number of pages9
JournalAIDS Research and Human Retroviruses
Volume15
Issue number3
DOIs
Publication statusPublished - Feb 10 1999
Externally publishedYes

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Human T-lymphotropic virus 1
Molecular Epidemiology
HTLV-I Infections
Taiwan
China
Population Groups
Islands
Population
Epidemiologic Studies
Blood Cells
Japan
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Community-based molecular epidemiology of HTLV type I in Taiwan and Kinmen : Implication of the origin of the cosmopolitan subtype in northeast Asia. / Chen, Yi Ming A.; Ting, Sing Tho; Lee, Cheng Ming; Liu, Wu Tse; Pan, Wen Harn; Cheng, Andrew T.A.; Chou, Pesus.

In: AIDS Research and Human Retroviruses, Vol. 15, No. 3, 10.02.1999, p. 229-237.

Research output: Contribution to journalArticle

Chen, Yi Ming A. ; Ting, Sing Tho ; Lee, Cheng Ming ; Liu, Wu Tse ; Pan, Wen Harn ; Cheng, Andrew T.A. ; Chou, Pesus. / Community-based molecular epidemiology of HTLV type I in Taiwan and Kinmen : Implication of the origin of the cosmopolitan subtype in northeast Asia. In: AIDS Research and Human Retroviruses. 1999 ; Vol. 15, No. 3. pp. 229-237.
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