Combining sandblasting, alkaline etching, and collagen immobilization to promote cell growth on biomedical titanium implants

Chia Fei Liu, Kai Chun Chang, Ying Sui Sun, Diem Thuy Nguyen, Her Hsiung Huang

Research output: Contribution to journalArticlepeer-review

Abstract

Our objective in this study was to promote the growth of bone cells on biomedical titanium (Ti) implant surfaces via surface modification involving sandblasting, alkaline etching, and type I collagen immobilization using the natural cross-linker genipin. The resulting surface was characterized in terms topography, roughness, wettability, and functional groups, respectively using field emission scanning electron microscopy, 3D profilometry, and attenuated total reflection-Fourier transform infrared spectroscopy. We then evaluated the adhesion, proliferation, initial differentiation, and mineralization of human bone marrow mesenchymal stem cells (hMSCs). Results show that sandblasting treatment greatly enhanced surface roughness to promote cell adhesion and proliferation and that the immobilization of type I collagen using genipin enhanced initial cell differentiation as well as mineralization in the extracellular matrix of hMSCs. Interestingly, the nano/submicro-scale pore network and/or hydrophilic features on sandblasted rough Ti surfaces were insufficient to promote cell growth. However, the combination of all proposed surface treatments produced ideal surface characteristics suited to Ti implant applications.

Original languageEnglish
Article number2550
JournalPolymers
Volume13
Issue number15
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Alkaline etching
  • Cell growth
  • Sandblasting
  • Surface modification
  • Titanium implant
  • Type I collagen immobilization

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics

Fingerprint

Dive into the research topics of 'Combining sandblasting, alkaline etching, and collagen immobilization to promote cell growth on biomedical titanium implants'. Together they form a unique fingerprint.

Cite this