Combined therapy with thioridazine decreases plasma levels of quetiapine in taiwanese schizophrenic patients

Shen Chieh Chang, Mong Liang Lu, Yue Chi Wang, Fang Wei Lin, Shu Huei Huang, Pei Hsin Kuo, Hsiu O. Ho, Tzu Hua Wu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: In this study, the authors studied the effect of thioridazine (TDZ) on the pharmacokinetic profile of quetiapine (QTP) in Taiwanese patients with schizophrenia. Methods: Sixteen subjects with schizophrenia were recruited for this study. The authors pretreated 8 patients with TDZ 50 mg daily continuously given until the end of the study. QTP was administered to all the participants, and their doses were escalated to 300 mg once daily over a 7-day period and maintained for another week. On day 15, blood samples were collected at 12 time points within an 8-hour interval. The authors assayed the plasma levels of QTP with a high-performance liquid chromatography system coupled with ultraviolet detector. Results: Significantly decreased plasma levels of QTP after oral administration were observed in patients comedicated with TDZ compared with the QTP monotherapy group at 1.5, 2, and 2.5 hours, and the P values were 0.046, 0.001, and 0.005, respectively. The Cmax of QTP was significantly lower in the group comedicated with TDZ (776.9 ± 175.2 versus 1452.3 ± 707.5 ng/mL; P = 0.002). The oral clearance of QTP was significantly higher in the combined group than in the monothreapy group (123.3 ± 66.8 versus 60.3 ± 28.5 L/h; P = 0.03). Other pharmacokinetic parameters were not significantly different. Conclusions: The coadministration of TDZ significantly decreased plasma QTP level and significantly increased the oral clearance of QTP. Although TDZ is switched to QTP, choosing larger doses of QTP for titration may be necessary to avoid the emergence of psychotic symptoms among schizophrenic patients.

Original languageEnglish
Pages (from-to)345-348
Number of pages4
JournalTherapeutic Drug Monitoring
Volume34
Issue number3
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Pharmacokinetic interaction
  • Quetiapine
  • Steady-state plasma concentration
  • Therapeutic drug monitoring
  • Thioridazine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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