Combined splenectomy does not improve survival in radical total gastrectomy for advanced gastric cardia cancer

Wen Liang Fang, Kuo Hung Huang, Chew Wun Wu, Jen Hao Chen, Su Shun Lo, Mao Chih Hsieh, King Han Shen, Anna Fen Yau Li

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aims: Splenectomy is the most common combined organ resection in the surgical management for gastric cardia cancer. The role of combined splenectomy is still controversial. Methodology: From January 1998 to December 2006, a total of 174 patients received radical total gastrectomy for advanced adenocarcinoma of cardia. Patients with previous gastric surgery or tumor invasion of pancreas or spleen were excluded. Among them, 115 patients were enrolled in this study. Patients were divided into group 1 (splenectomy, n=47) and group 2 (spleen preservation, n=68). Their clinicopathological characteristics were compared. Results: Multivariate analysis showed that only tumor size and lymphovascular invasion were two independent indicators of survival. The surgically-related morbidity and mortality rates were similar between the two groups. Among the 3 patients with splenic hilar lymph nodes metastasis, all of them had large tumor size (≥4cm), advanced stage (stage III and IV) and tumor center located at the posterior wall of stomach. The 5-year overall survival for advanced cancer was similar (57.1% vs. 60.2%, p=0.681). Conclusions: Splenectomy does not improve overall survival in the management of advanced gastric cardia cancer. Splenectomy has limited clinical benefits except for large advanced tumors located at the posterior wall of stomach.

Original languageEnglish
Pages (from-to)1150-1154
Number of pages5
JournalHepato-Gastroenterology
Volume59
Issue number116
DOIs
Publication statusPublished - Jun 2012

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Keywords

  • Spleen preservation
  • Splenectomy
  • Survival

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Fang, W. L., Huang, K. H., Wu, C. W., Chen, J. H., Lo, S. S., Hsieh, M. C., Shen, K. H., & Li, A. F. Y. (2012). Combined splenectomy does not improve survival in radical total gastrectomy for advanced gastric cardia cancer. Hepato-Gastroenterology, 59(116), 1150-1154. https://doi.org/10.5754/hge10429