TY - JOUR
T1 - Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks
AU - Tsai, Hsiu Ting
AU - Hsieh, Ming Ju
AU - Lin, Chiao Wen
AU - Su, Shih Chi
AU - Miao, Nae Fang
AU - Yang, Shun Fa
AU - Huang, Hui Chuan
AU - Lai, Fu Chih
AU - Liu, Yu Fan
N1 - Funding Information:
This study was financially supported by grants from Ministry of Science and Technology, Taiwan (MOST 102-2314-B-040-002) and (MOST 103-2314-B-040-005-MY3). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2017 Tsai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Background We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status. Methodology/Principal findings In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07∼2.31 and OR, 1.58; 95% CI, 1.04∼2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65∼11.01; p = 0.002), 2.34-(95% CI: 1.19∼4.61; p = 0.01), and 2.34-fold (95% CI: 1.38∼3.96; p = 0.001) higher risks of developing oral cancer. Conclusions Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.
AB - Background We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status. Methodology/Principal findings In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07∼2.31 and OR, 1.58; 95% CI, 1.04∼2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65∼11.01; p = 0.002), 2.34-(95% CI: 1.19∼4.61; p = 0.01), and 2.34-fold (95% CI: 1.38∼3.96; p = 0.001) higher risks of developing oral cancer. Conclusions Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.
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U2 - 10.1371/journal.pone.0163369
DO - 10.1371/journal.pone.0163369
M3 - Article
C2 - 28339463
AN - SCOPUS:85016149561
SN - 1932-6203
VL - 12
JO - PLoS One
JF - PLoS One
IS - 3
M1 - e0163369
ER -
