TY - JOUR
T1 - Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks
AU - Tsai, Hsiu Ting
AU - Hsieh, Ming Ju
AU - Lin, Chiao Wen
AU - Su, Shih Chi
AU - Miao, Nae Fang
AU - Yang, Shun Fa
AU - Huang, Hui Chuan
AU - Lai, Fu Chih
AU - Liu, Yu Fan
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Background We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status. Methodology/Principal findings In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07∼2.31 and OR, 1.58; 95% CI, 1.04∼2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65∼11.01; p = 0.002), 2.34-(95% CI: 1.19∼4.61; p = 0.01), and 2.34-fold (95% CI: 1.38∼3.96; p = 0.001) higher risks of developing oral cancer. Conclusions Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.
AB - Background We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status. Methodology/Principal findings In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07∼2.31 and OR, 1.58; 95% CI, 1.04∼2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65∼11.01; p = 0.002), 2.34-(95% CI: 1.19∼4.61; p = 0.01), and 2.34-fold (95% CI: 1.38∼3.96; p = 0.001) higher risks of developing oral cancer. Conclusions Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.
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U2 - 10.1371/journal.pone.0163369
DO - 10.1371/journal.pone.0163369
M3 - Article
C2 - 28339463
AN - SCOPUS:85016149561
VL - 12
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 3
M1 - e0163369
ER -
