Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks

Hsiu Ting Tsai, Ming Ju Hsieh, Chiao Wen Lin, Shih Chi Su, Nae Fang Miao, Shun Fa Yang, Hui Chuan Huang, Fu Chih Lai, Yu Fan Liu

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2 Citations (Scopus)


Background We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status. Methodology/Principal findings In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07∼2.31 and OR, 1.58; 95% CI, 1.04∼2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65∼11.01; p = 0.002), 2.34-(95% CI: 1.19∼4.61; p = 0.01), and 2.34-fold (95% CI: 1.38∼3.96; p = 0.001) higher risks of developing oral cancer. Conclusions Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.

Original languageEnglish
Article numbere0163369
JournalPLoS One
Issue number3
Publication statusPublished - Mar 1 2017


ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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