Combination treatment of interferon β-1b and warfarin for a patient with baló's concentric sclerosis and antiphospholipid syndrome

An Chen Tso, Wen Long Tsao, Cheng Yu Chen, Chwan Fen Yang, Giia Sheun Peng

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Baló's concentric sclerosis (BCS), a rare variant of multiple sclerosis (MS), as the initial presentation of antiphospholipid syndrome (APS) is unusual. The pathogenic role of antiphospholipid antibodies in the development of MS remains unknown. Anticoagulant therapy might be used in patients with MS and APS for prevention against the relapse of MS. Case Report: We present a 27-year-old man diagnosed as BCS with APS. Initially, after corticosteroid therapy, he exhibited a complete recovery. During follow-up, his Baló-like lesion dissolved over time but transformed into other asymptomatic MS-like lesions. He also had persistently elevated anticardiolipin IgG levels. The patient was, therefore, on a combined therapy of interferon β-1b and an anticoagulant agent. No new brain lesions were found on 2 occasional head magnetic resonance imaging studies at 1 year follow-up. Conclusions: To prevent further MS relapse and thrombotic complications of APS, a combined therapy of interferon β-1b and an anticoagulant agent can be an important strategy in treating patients with both BCS and APS.

Original languageEnglish
Pages (from-to)46-48
Number of pages3
JournalNeurologist
Volume19
Issue number2
DOIs
Publication statusPublished - Jan 2 2015
Externally publishedYes

Fingerprint

Antiphospholipid Syndrome
Sclerosis
Warfarin
Interferons
Multiple Sclerosis
Anticoagulants
Therapeutics
Antiphospholipid Antibodies
Secondary Prevention
Adrenal Cortex Hormones
Immunoglobulin G
Head
Magnetic Resonance Imaging
Recurrence
Brain

Keywords

  • anticoagulant
  • antiphospholipid syndrome
  • Baló's concentric sclerosis
  • multiple sclerosis
  • susceptibility-weighted imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Medicine(all)

Cite this

Combination treatment of interferon β-1b and warfarin for a patient with baló's concentric sclerosis and antiphospholipid syndrome. / Tso, An Chen; Tsao, Wen Long; Chen, Cheng Yu; Yang, Chwan Fen; Peng, Giia Sheun.

In: Neurologist, Vol. 19, No. 2, 02.01.2015, p. 46-48.

Research output: Contribution to journalArticle

Tso, An Chen ; Tsao, Wen Long ; Chen, Cheng Yu ; Yang, Chwan Fen ; Peng, Giia Sheun. / Combination treatment of interferon β-1b and warfarin for a patient with baló's concentric sclerosis and antiphospholipid syndrome. In: Neurologist. 2015 ; Vol. 19, No. 2. pp. 46-48.
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