Abstract

Background: Few studies have evaluated the risk of oral cavity cancer (OC) in patients with recurrent oral aphthae (ROA) and dry eye syndrome (DES). This study assessed the risk of OC in patients who had received diagnoses of ROA and DES in Taiwan. Methods: A population-based frequency-matched case–control study was conducted in which data were analyzed from the National Health Insurance Research Database of Taiwan. Patients with ROA and DES were identified as the case cohort. Patients and controls without ROA and DES were frequency matched (1:4) on the basis of age, sex, monthly income, geographical location, and urbanization level. Chi-squared tests were conducted to compare demographic factor distributions between the patients and controls. Cox proportional hazards models were used to calculate the adjusted hazard ratios (aHRs) and 95% CI of OC diagnoses among the patients and controls. Risk consistency between the two cohorts was determined using subgroup analysis. Results: A total of 7,110 patients with ROA and DES and 28,388 controls were identified. The OC risk was significantly higher for female patients than controls (aHR=3.41, 95% CI=1.69– 6.86). Furthermore, women aged 50–69 years exhibited a higher risk of OC than those in the other age groups. Female patients aged 50–59 years exhibited the highest aHR for OC (aHR=5.56, 95% CI=1.70–18.25), followed by those aged 60–69 years (aHR=4.34, 95% CI=1.26–15.99). Conclusion: ROA and DES may be associated with a high risk of OC in elderly women.

Original languageEnglish
Pages (from-to)3273-3281
Number of pages9
JournalCancer Management and Research
Volume10
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Dry Eye Syndromes
Aphthous Stomatitis
Mouth Neoplasms
Mouth
Taiwan
Oral Diagnosis
Urbanization
National Health Programs
Proportional Hazards Models
Age Groups
Demography
Databases

Keywords

  • Dry eye syndrome
  • Oral cavity cancer
  • Recurrent oral aphthae
  • Risk factor
  • Women

ASJC Scopus subject areas

  • Oncology

Cite this

@article{2c72fd8672c3486a883056b383b1b117,
title = "Combination of recurrent oral aphthae and dry eye syndrome may constitute an independent risk factor for oral cavity cancer in elderly women",
abstract = "Background: Few studies have evaluated the risk of oral cavity cancer (OC) in patients with recurrent oral aphthae (ROA) and dry eye syndrome (DES). This study assessed the risk of OC in patients who had received diagnoses of ROA and DES in Taiwan. Methods: A population-based frequency-matched case–control study was conducted in which data were analyzed from the National Health Insurance Research Database of Taiwan. Patients with ROA and DES were identified as the case cohort. Patients and controls without ROA and DES were frequency matched (1:4) on the basis of age, sex, monthly income, geographical location, and urbanization level. Chi-squared tests were conducted to compare demographic factor distributions between the patients and controls. Cox proportional hazards models were used to calculate the adjusted hazard ratios (aHRs) and 95{\%} CI of OC diagnoses among the patients and controls. Risk consistency between the two cohorts was determined using subgroup analysis. Results: A total of 7,110 patients with ROA and DES and 28,388 controls were identified. The OC risk was significantly higher for female patients than controls (aHR=3.41, 95{\%} CI=1.69– 6.86). Furthermore, women aged 50–69 years exhibited a higher risk of OC than those in the other age groups. Female patients aged 50–59 years exhibited the highest aHR for OC (aHR=5.56, 95{\%} CI=1.70–18.25), followed by those aged 60–69 years (aHR=4.34, 95{\%} CI=1.26–15.99). Conclusion: ROA and DES may be associated with a high risk of OC in elderly women.",
keywords = "Dry eye syndrome, Oral cavity cancer, Recurrent oral aphthae, Risk factor, Women",
author = "Lei Qin and Kao, {Yi Wei} and Lin, {Yueh Lung} and Peng, {Bou Yue} and Deng, {Win Ping} and Chen, {Tsung Ming} and Lin, {Kuan Chou} and Yuan, {Kevin Sheng Po} and Wu, {Alexander T.H.} and Shia, {Ben Chang} and Wu, {Szu Yuan}",
year = "2018",
month = "1",
day = "1",
doi = "10.2147/CMAR.S168477",
language = "English",
volume = "10",
pages = "3273--3281",
journal = "Cancer Management and Research",
issn = "1179-1322",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Combination of recurrent oral aphthae and dry eye syndrome may constitute an independent risk factor for oral cavity cancer in elderly women

AU - Qin, Lei

AU - Kao, Yi Wei

AU - Lin, Yueh Lung

AU - Peng, Bou Yue

AU - Deng, Win Ping

AU - Chen, Tsung Ming

AU - Lin, Kuan Chou

AU - Yuan, Kevin Sheng Po

AU - Wu, Alexander T.H.

AU - Shia, Ben Chang

AU - Wu, Szu Yuan

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Few studies have evaluated the risk of oral cavity cancer (OC) in patients with recurrent oral aphthae (ROA) and dry eye syndrome (DES). This study assessed the risk of OC in patients who had received diagnoses of ROA and DES in Taiwan. Methods: A population-based frequency-matched case–control study was conducted in which data were analyzed from the National Health Insurance Research Database of Taiwan. Patients with ROA and DES were identified as the case cohort. Patients and controls without ROA and DES were frequency matched (1:4) on the basis of age, sex, monthly income, geographical location, and urbanization level. Chi-squared tests were conducted to compare demographic factor distributions between the patients and controls. Cox proportional hazards models were used to calculate the adjusted hazard ratios (aHRs) and 95% CI of OC diagnoses among the patients and controls. Risk consistency between the two cohorts was determined using subgroup analysis. Results: A total of 7,110 patients with ROA and DES and 28,388 controls were identified. The OC risk was significantly higher for female patients than controls (aHR=3.41, 95% CI=1.69– 6.86). Furthermore, women aged 50–69 years exhibited a higher risk of OC than those in the other age groups. Female patients aged 50–59 years exhibited the highest aHR for OC (aHR=5.56, 95% CI=1.70–18.25), followed by those aged 60–69 years (aHR=4.34, 95% CI=1.26–15.99). Conclusion: ROA and DES may be associated with a high risk of OC in elderly women.

AB - Background: Few studies have evaluated the risk of oral cavity cancer (OC) in patients with recurrent oral aphthae (ROA) and dry eye syndrome (DES). This study assessed the risk of OC in patients who had received diagnoses of ROA and DES in Taiwan. Methods: A population-based frequency-matched case–control study was conducted in which data were analyzed from the National Health Insurance Research Database of Taiwan. Patients with ROA and DES were identified as the case cohort. Patients and controls without ROA and DES were frequency matched (1:4) on the basis of age, sex, monthly income, geographical location, and urbanization level. Chi-squared tests were conducted to compare demographic factor distributions between the patients and controls. Cox proportional hazards models were used to calculate the adjusted hazard ratios (aHRs) and 95% CI of OC diagnoses among the patients and controls. Risk consistency between the two cohorts was determined using subgroup analysis. Results: A total of 7,110 patients with ROA and DES and 28,388 controls were identified. The OC risk was significantly higher for female patients than controls (aHR=3.41, 95% CI=1.69– 6.86). Furthermore, women aged 50–69 years exhibited a higher risk of OC than those in the other age groups. Female patients aged 50–59 years exhibited the highest aHR for OC (aHR=5.56, 95% CI=1.70–18.25), followed by those aged 60–69 years (aHR=4.34, 95% CI=1.26–15.99). Conclusion: ROA and DES may be associated with a high risk of OC in elderly women.

KW - Dry eye syndrome

KW - Oral cavity cancer

KW - Recurrent oral aphthae

KW - Risk factor

KW - Women

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U2 - 10.2147/CMAR.S168477

DO - 10.2147/CMAR.S168477

M3 - Article

VL - 10

SP - 3273

EP - 3281

JO - Cancer Management and Research

JF - Cancer Management and Research

SN - 1179-1322

ER -