Combination of molecular assay and clinical evaluation for early confirmation of tuberculosis cases

Hui Z. Tu, Yao Shen Chen, Y. E. Lin, M. R. Tseng, Tsi S. Huang, Hung Chin Tsai, Yung-Ching Liu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The cost-effectiveness of the ProbeTec ET Direct TB assay (DTB) was compared with that of culture for detection of Mycobacterium tuberculosis complex in 361 acid-fast stain-positive respiratory specimens. The overall sensitivity, specificity, positive predictive value and negative predictive value of DTB were 97.7%, 86.6%, 87.2% and 97.6%, respectively. When clinical evaluation was added to DTB, the specificity and positive predictive value of DTB increased to 94.7% and 95.4%, respectively. Treatment costs of $133521 would have been saved in this cohort if DTB, instead of culture results, had been used to eliminate 'false-positive' smear results.

Original languageEnglish
Pages (from-to)712-714
Number of pages3
JournalClinical Microbiology and Infection
Volume17
Issue number5
DOIs
Publication statusPublished - May 2011

Keywords

  • Clinical diagnosis
  • Cost-effective diagnostic method
  • Non-tuberculosis mycobacteria
  • Strand displacement amplification
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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