Combination of baclofen and antimuscarinics to reduce voiding difficulty in treating women with overactive bladders

H. Y. Chin, K. C. Lin, C. H. Chiang, C. J. Wang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purposte of study: To evaluate the efficacy of baclofen in combination with antimuscarinics to treat women with an overactive bladder (OAB) with abnormal voiding patterns. Methods: An action research and chart review was conducted in 245 OAB women. Women were prescribed tolterodine or oxybutynin with or without baclofen after urodynamics. The complaint of voiding difficulty was followed up one week later. Results: There was a significant difference in the occurrence of voiding difficulty after antimuscarinic administration in OAB women with abnormal voiding patterns compared with normal patterns (18% vs 4.9%, respectively; p = 0.013). The clinical difference of voiding difficulty after treating with antimuscarinics between both voiding patterns disappeared after adding baclofen (abnormal voiding pattern vs normal pattern; 11.1% vs 5.6%, respectively; p = 1.000). Conclusion: Combined use of baclofen and antimuscarinic agents could reduce voiding difficulty in treating women with overactive bladders with abnormal voiding patterns.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalClinical and Experimental Obstetrics and Gynecology
Volume39
Issue number2
Publication statusPublished - Jul 13 2012
Externally publishedYes

Keywords

  • Antimuscarinics
  • Baclofen
  • Overactive bladder
  • Urodynamics
  • Voiding pattern

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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