Combination of 13-cis retinoic acid and interferon-α in the treatment of recurrent or refractory peripheral T-cell lymphoma

Chin Lun Huang, Zhong Zhe Lin, Ih Jen Su, Tsu Yi Chao, Hwei Fang Tien, Ming Chih Chang, Ming Che Huang, Woei Yau Kao, Jih Luh Tang, Kun Heui Yeh, Chiu Hwa Wang, Chih Hung Hsu, Mei Yin Liu, Ann Lii Cheng

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9 Citations (Scopus)

Abstract

We previously reported the therapeutic efficacy of 13-cis retinoic acid (13-cRA) in some subtypes of peripheral T-cell lymphoma (PTCL). This study sought to clarify if the addition of interferon-α2a (IFN-α2a), an agent with synergistic cytotoxicity with 13-cRA in many types of malignant cells, may be more effective in the treatment of PTCL. Eligible patients has histologically proven PTCL, which was recurrent after or refractory to anthracycline-containing systemic chemotherapy. The treatment included oral administration of 13-cRA 1 mg/kg/day, divided into three doses, and intramuscular injection of IFN-α2a 4.5 MU/m2, three times per week. From March 1995 to July 2000, a total of 17 patients, 10 men and 7 women, with a median age of 47 years (range, 18-77 years), were recruited. The histologic diagnosis included 7 cases of unspecified PTCL, 6 cases of Ki-1 anaplastic large cell lymphoma (ALCL), 1 case of angioimmunoblastic T-cell lymphoma, and 3 cases of angiocentric nasal NK/T cell lymphoma. They received a median of 1.7 months of treatment (range, 0.4-13.3 months). One patient refused further treatment due to toxicity. The doses of 13-cRA and IFN-α2a had to be decreased in 7 and 7 patients, respectively. Grade III/IV hematologic and non-hematologic toxicity developed in 2 and 5 patients, respectively. There were 5 partial responses (Ki-1, 4; unspecified PTCL, 1), with a total response rate of 31.3% (95% Cl, 5.7-56.8%). The median duration of response for the responders was 2.5 months (range, 0.8-7.2 months). The median overall survival for the entire group of patients was 3.6 months. In conclusion, a combination of 13-cRA and IFN-α2a is a useful salvage treatment for selected patients with recurrent or refractory PTCL, particularly those with the Ki-1 subtype. However, the data does not support that addition of IFN-α2a is superior to 13-cRA alone.

Original languageEnglish
Pages (from-to)1415-1420
Number of pages6
JournalLeukemia and Lymphoma
Volume43
Issue number7
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • 13-cis retinoic acid
  • Interferon-α
  • Ki-1 lymphoma
  • T-cell lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Huang, C. L., Lin, Z. Z., Su, I. J., Chao, T. Y., Tien, H. F., Chang, M. C., Huang, M. C., Kao, W. Y., Tang, J. L., Yeh, K. H., Wang, C. H., Hsu, C. H., Liu, M. Y., & Cheng, A. L. (2002). Combination of 13-cis retinoic acid and interferon-α in the treatment of recurrent or refractory peripheral T-cell lymphoma. Leukemia and Lymphoma, 43(7), 1415-1420.