Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review

Navneet Kumar Dubey, Viraj Krishna Mishra, Rajni Dubey, Shabbir Syed-Abdul, Joseph R Wang, Peter D Wang, Win-Ping Deng

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Knee osteoarthritis (OA) is a chronic degenerative disorder which could be distinguished by erosion of articular cartilage, pain, stiffness, and crepitus. Not only aging-associated alterations but also the metabolic factors such as hyperglycemia, dyslipidemia, and obesity affect articular tissues and may initiate or exacerbate the OA. The poor self-healing ability of articular cartilage due to limited regeneration in chondrocytes further adversely affects the osteoarthritic microenvironment. Traditional and current surgical treatment procedures for OA are limited and incapable to reverse the damage of articular cartilage. To overcome these limitations, cell-based therapies are currently being employed to repair and regenerate the structure and function of articular tissues. These therapies not only depend upon source and type of stem cells but also on environmental conditions, growth factors, and chemical and mechanical stimuli. Recently, the pluripotent and various multipotent mesenchymal stem cells have been employed for OA therapy, due to their differentiation potential towards chondrogenic lineage. Additionally, the stem cells have also been supplemented with growth factors to achieve higher healing response in osteoarthritic cartilage. In this review, we summarized the current status of stem cell therapies in OA pathophysiology and also highlighted the potential areas of further research needed in regenerative medicine.

Original languageEnglish
Article number5421019
Pages (from-to)1-13
Number of pages13
JournalStem Cells International
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

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Cell- and Tissue-Based Therapy
Osteoarthritis
Cartilage
Articular Cartilage
Stem Cells
Intercellular Signaling Peptides and Proteins
Joints
Multipotent Stem Cells
Aptitude
Regenerative Medicine
Knee Osteoarthritis
Chondrocytes
Dyslipidemias
Mesenchymal Stromal Cells
Hyperglycemia
Regeneration
Therapeutics
Obesity
Pain
Research

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Dubey, N. K., Mishra, V. K., Dubey, R., Syed-Abdul, S., Wang, J. R., Wang, P. D., & Deng, W-P. (2018). Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review. Stem Cells International, 2018, 1-13. [5421019]. https://doi.org/10.1155/2018/5421019

Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage : A Review. / Dubey, Navneet Kumar; Mishra, Viraj Krishna; Dubey, Rajni; Syed-Abdul, Shabbir; Wang, Joseph R; Wang, Peter D; Deng, Win-Ping.

In: Stem Cells International, Vol. 2018, 5421019, 01.01.2018, p. 1-13.

Research output: Contribution to journalReview article

Dubey, NK, Mishra, VK, Dubey, R, Syed-Abdul, S, Wang, JR, Wang, PD & Deng, W-P 2018, 'Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review', Stem Cells International, vol. 2018, 5421019, pp. 1-13. https://doi.org/10.1155/2018/5421019
Dubey NK, Mishra VK, Dubey R, Syed-Abdul S, Wang JR, Wang PD et al. Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review. Stem Cells International. 2018 Jan 1;2018:1-13. 5421019. https://doi.org/10.1155/2018/5421019
Dubey, Navneet Kumar ; Mishra, Viraj Krishna ; Dubey, Rajni ; Syed-Abdul, Shabbir ; Wang, Joseph R ; Wang, Peter D ; Deng, Win-Ping. / Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage : A Review. In: Stem Cells International. 2018 ; Vol. 2018. pp. 1-13.
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