Collapsin response mediator protein-1: A novel invasion-suppressor gene

Jin Yuan Shih, Yuan Chii G Lee, Shuenn Chen Yang, Tse Ming Hong, Chi Ying F Huang, Pan Chyr Yang

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-1 inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-1 mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells.

Original languageEnglish
Pages (from-to)69-76
Number of pages8
JournalClinical and Experimental Metastasis
Volume20
Issue number1
DOIs
Publication statusPublished - 2003
Externally publishedYes

Fingerprint

Suppressor Genes
Semaphorins
Neoplasm Metastasis
Neoplasms
Growth Cones
Pseudopodia
Phosphoproteins
collapsin response mediator protein-1
Computational Biology
Genes
Actins
Lung Neoplasms
Lymph Nodes
Recurrence
Messenger RNA

Keywords

  • CRMP
  • Invasion
  • Metastasis
  • Microarray
  • Semaphorin

ASJC Scopus subject areas

  • Cancer Research

Cite this

Collapsin response mediator protein-1 : A novel invasion-suppressor gene. / Shih, Jin Yuan; Lee, Yuan Chii G; Yang, Shuenn Chen; Hong, Tse Ming; Huang, Chi Ying F; Yang, Pan Chyr.

In: Clinical and Experimental Metastasis, Vol. 20, No. 1, 2003, p. 69-76.

Research output: Contribution to journalArticle

Shih, Jin Yuan ; Lee, Yuan Chii G ; Yang, Shuenn Chen ; Hong, Tse Ming ; Huang, Chi Ying F ; Yang, Pan Chyr. / Collapsin response mediator protein-1 : A novel invasion-suppressor gene. In: Clinical and Experimental Metastasis. 2003 ; Vol. 20, No. 1. pp. 69-76.
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