Abstract
Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-1 inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-1 mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells.
| Original language | English |
|---|---|
| Pages (from-to) | 69-76 |
| Number of pages | 8 |
| Journal | Clinical and Experimental Metastasis |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2003 |
| Externally published | Yes |
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Keywords
- CRMP
- Invasion
- Metastasis
- Microarray
- Semaphorin
ASJC Scopus subject areas
- Cancer Research
Cite this
Collapsin response mediator protein-1 : A novel invasion-suppressor gene. / Shih, Jin Yuan; Lee, Yuan Chii G; Yang, Shuenn Chen; Hong, Tse Ming; Huang, Chi Ying F; Yang, Pan Chyr.
In: Clinical and Experimental Metastasis, Vol. 20, No. 1, 2003, p. 69-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Collapsin response mediator protein-1
T2 - A novel invasion-suppressor gene
AU - Shih, Jin Yuan
AU - Lee, Yuan Chii G
AU - Yang, Shuenn Chen
AU - Hong, Tse Ming
AU - Huang, Chi Ying F
AU - Yang, Pan Chyr
PY - 2003
Y1 - 2003
N2 - Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-1 inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-1 mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells.
AB - Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-1 inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-1 mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells.
KW - CRMP
KW - Invasion
KW - Metastasis
KW - Microarray
KW - Semaphorin
UR - http://www.scopus.com/inward/record.url?scp=0037219922&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037219922&partnerID=8YFLogxK
U2 - 10.1023/A:1022598604565
DO - 10.1023/A:1022598604565
M3 - Article
C2 - 12650609
AN - SCOPUS:0037219922
VL - 20
SP - 69
EP - 76
JO - Clinical and Experimental Metastasis
JF - Clinical and Experimental Metastasis
SN - 0262-0898
IS - 1
ER -