Collagen-Glycosaminoglycan Matrix Implantation Promotes Angiogenesis following Surgical Brain Trauma

Kuo Feng Huang, Wei-Cherng Hsu, Jong Kai Hsiao, Gunng Shinng Chen, Jia Yi Wang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Surgical brain injury (SBI) is unavoidable during many neurosurgical procedures intrinsically linked to postoperative neurological deficits. We have previously demonstrated that implantation of collagen glycosaminoglycan (CG) following surgical brain injury could significantly promote functional recovery and neurogenesis. In this study we further hypothesized that this scaffold may provide a microenvironment by promoting angiogenesis to favor neurogenesis and subsequent functional recovery. Using the rodent model of surgical brain injury as we previously established, we divided Sprague-Dawley male rats (weighting 300-350 g) into three groups: (1) sham (2) surgical injury with a lesion (L), and (3) L with CG matrix implantation (L + CG). Our results demonstrated that L + CG group showed a statistically significant increase in the density of vascular endothelial cells and blood vessels over time. In addition, tissue concentrations of angiogenic growth factors (such as VEGF, FGF2, and PDGF) significantly increased in L + CG group. These results suggest that implantation of a CG scaffold can promote vascularization accompanied by neurogenesis. This opens prospects for use of CG scaffolds in conditions such as brain injury including trauma and ischemia.

Original languageEnglish
Article number672409
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Glycosaminoglycans
Brain
Collagen
Intraoperative Complications
Brain Injuries
Neurogenesis
Scaffolds
Neurosurgical Procedures
Recovery
Angiogenesis Inducing Agents
Endothelial cells
Blood vessels
Fibroblast Growth Factor 2
Scaffolds (biology)
Traumatic Brain Injury
Vascular Endothelial Growth Factor A
Blood Vessels
Sprague Dawley Rats
Rats
Rodentia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Collagen-Glycosaminoglycan Matrix Implantation Promotes Angiogenesis following Surgical Brain Trauma. / Huang, Kuo Feng; Hsu, Wei-Cherng; Hsiao, Jong Kai; Chen, Gunng Shinng; Wang, Jia Yi.

In: BioMed Research International, Vol. 2014, 672409, 2014.

Research output: Contribution to journalArticle

Huang, Kuo Feng ; Hsu, Wei-Cherng ; Hsiao, Jong Kai ; Chen, Gunng Shinng ; Wang, Jia Yi. / Collagen-Glycosaminoglycan Matrix Implantation Promotes Angiogenesis following Surgical Brain Trauma. In: BioMed Research International. 2014 ; Vol. 2014.
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