Abstract
Introduction: Symptomatic intracranial hemorrhage (sICH) is a serious complication of IV rt-PA therapy after acute ischemic stroke. Independent sICH predictors have been previously derived using case–control studies. Here we utilized a novel cohort-based comparison to identify additional independent predictors of sICH. Methods: We included 210 patients receiving IV rt-PA therapy from January 2009 through December 2013 at the Yale-New Haven Stroke Center. Clinical parameters were compared using Mann–Whitney tests, two-sample tests of proportions and two-sample t tests. Logistic regression was performed using sICH as the dependent variable. Predictive ability was assessed using areas under the receiver operating characteristic (ROC) curve. Results: sICH rates were lowest from 2010 to 2012 and comprised the low sICH cohort (2.0 % sICH), compared to the high sICH cohort from 2009 to 2013 (9.2 % sICH, P = 0.025). Patients in the low sICH cohort had significantly more visual field deficits (38.6 vs. 24.8 %, P = 0.03) and decreased levels of consciousness (62.4 vs. 39.4 %, P
| Original language | English |
|---|---|
| Pages (from-to) | 394-400 |
| Number of pages | 7 |
| Journal | Neurocritical Care |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Dec 1 2015 |
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Keywords
- Intracerebral hemorrhage
- IV Thrombolysis
- Neurocritical care
ASJC Scopus subject areas
- Clinical Neurology
- Critical Care and Intensive Care Medicine
Cite this
Cohort-Based Identification of Predictors of Symptomatic Intracerebral Hemorrhage After IV Thrombolysis. / Asuzu, David; Nyström, Karin; Amin, Hardik; Schindler, Joseph; Wira, Charles; Greer, David; Chi, Nai Fang; Halliday, Janet; Sheth, Kevin N.
In: Neurocritical Care, Vol. 23, No. 3, 01.12.2015, p. 394-400.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cohort-Based Identification of Predictors of Symptomatic Intracerebral Hemorrhage After IV Thrombolysis
AU - Asuzu, David
AU - Nyström, Karin
AU - Amin, Hardik
AU - Schindler, Joseph
AU - Wira, Charles
AU - Greer, David
AU - Chi, Nai Fang
AU - Halliday, Janet
AU - Sheth, Kevin N.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Introduction: Symptomatic intracranial hemorrhage (sICH) is a serious complication of IV rt-PA therapy after acute ischemic stroke. Independent sICH predictors have been previously derived using case–control studies. Here we utilized a novel cohort-based comparison to identify additional independent predictors of sICH. Methods: We included 210 patients receiving IV rt-PA therapy from January 2009 through December 2013 at the Yale-New Haven Stroke Center. Clinical parameters were compared using Mann–Whitney tests, two-sample tests of proportions and two-sample t tests. Logistic regression was performed using sICH as the dependent variable. Predictive ability was assessed using areas under the receiver operating characteristic (ROC) curve. Results: sICH rates were lowest from 2010 to 2012 and comprised the low sICH cohort (2.0 % sICH), compared to the high sICH cohort from 2009 to 2013 (9.2 % sICH, P = 0.025). Patients in the low sICH cohort had significantly more visual field deficits (38.6 vs. 24.8 %, P = 0.03) and decreased levels of consciousness (62.4 vs. 39.4 %, P
AB - Introduction: Symptomatic intracranial hemorrhage (sICH) is a serious complication of IV rt-PA therapy after acute ischemic stroke. Independent sICH predictors have been previously derived using case–control studies. Here we utilized a novel cohort-based comparison to identify additional independent predictors of sICH. Methods: We included 210 patients receiving IV rt-PA therapy from January 2009 through December 2013 at the Yale-New Haven Stroke Center. Clinical parameters were compared using Mann–Whitney tests, two-sample tests of proportions and two-sample t tests. Logistic regression was performed using sICH as the dependent variable. Predictive ability was assessed using areas under the receiver operating characteristic (ROC) curve. Results: sICH rates were lowest from 2010 to 2012 and comprised the low sICH cohort (2.0 % sICH), compared to the high sICH cohort from 2009 to 2013 (9.2 % sICH, P = 0.025). Patients in the low sICH cohort had significantly more visual field deficits (38.6 vs. 24.8 %, P = 0.03) and decreased levels of consciousness (62.4 vs. 39.4 %, P
KW - Intracerebral hemorrhage
KW - IV Thrombolysis
KW - Neurocritical care
UR - http://www.scopus.com/inward/record.url?scp=84958111243&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958111243&partnerID=8YFLogxK
U2 - 10.1007/s12028-015-0121-1
DO - 10.1007/s12028-015-0121-1
M3 - Article
C2 - 25691004
AN - SCOPUS:84958111243
VL - 23
SP - 394
EP - 400
JO - Neurocritical Care
JF - Neurocritical Care
SN - 1541-6933
IS - 3
ER -