4 Citations (Scopus)

Abstract

Objective Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological tests have been inconsistent. The aim of the study was to determine domain-specific cognitive impairment in patients with fibromyalgia compared with healthy controls. Methods We conducted a meta-analysis that systematically searched six databases (PubMed, Ovid MEDLINE, Embase, CINAHL, PsycINFO, and Web of Science) for articles published before September 2017. Results Twenty-three case-control studies with a total of 2096 participants were included in the meta-analysis. Cognitive function was significantly lower (g = 0.87, 95% confidence interval [CI] = 0.60-1.15) in individuals with fibromyalgia than in healthy controls. Large effect sizes were found in learning/memory and attention/psychomotor speed (g = 0.94, p =.013; g = 1.22, p <.001, respectively); medium effect sizes were reported in executive function and working memory (g = 0.72, p <.001; g = 0.75, p <.001, respectively). Depression and anxiety scores were associated with the effect size of group differences in cognitive function (B = 0.11, p <.001, 95% CI = 0.09-0.13; B = 0.02, p <.001, 95% CI = 0.01-0.02, respectively). Conclusions Cognitive impairment across different cognitive domains was found in individuals with fibromyalgia compared with healthy controls. Mood states (depression and anxiety) may explain the heterogeneity across studies.

Original languageEnglish
Pages (from-to)432-438
Number of pages7
JournalPsychosomatic Medicine
Volume80
Issue number5
DOIs
Publication statusPublished - Jun 1 2018

Fingerprint

Fibromyalgia
Meta-Analysis
Case-Control Studies
Cognition
Confidence Intervals
Anxiety
Depression
Neuropsychological Tests
Executive Function
Short-Term Memory
PubMed
MEDLINE
Learning
Databases
Cognitive Dysfunction

Keywords

  • ACR = American College of Rheumatology
  • ACT = Auditory Consonant Trigram
  • BAI = Beck Anxiety Inventory
  • BDI = Beck Depression Inventory
  • BSI = Brief Symptom Inventory
  • Cognitive function
  • Fibromyalgia
  • Meta-analysis
  • Pain

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Cognitive impairment in fibromyalgia : A meta-analysis of case-control studies. / Wu, Yu Lin; Huang, Chun Jen; Fang, Su Chen; Ko, Ling Hsin; Tsai, Pei Shan.

In: Psychosomatic Medicine, Vol. 80, No. 5, 01.06.2018, p. 432-438.

Research output: Contribution to journalReview article

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abstract = "Objective Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological tests have been inconsistent. The aim of the study was to determine domain-specific cognitive impairment in patients with fibromyalgia compared with healthy controls. Methods We conducted a meta-analysis that systematically searched six databases (PubMed, Ovid MEDLINE, Embase, CINAHL, PsycINFO, and Web of Science) for articles published before September 2017. Results Twenty-three case-control studies with a total of 2096 participants were included in the meta-analysis. Cognitive function was significantly lower (g = 0.87, 95{\%} confidence interval [CI] = 0.60-1.15) in individuals with fibromyalgia than in healthy controls. Large effect sizes were found in learning/memory and attention/psychomotor speed (g = 0.94, p =.013; g = 1.22, p <.001, respectively); medium effect sizes were reported in executive function and working memory (g = 0.72, p <.001; g = 0.75, p <.001, respectively). Depression and anxiety scores were associated with the effect size of group differences in cognitive function (B = 0.11, p <.001, 95{\%} CI = 0.09-0.13; B = 0.02, p <.001, 95{\%} CI = 0.01-0.02, respectively). Conclusions Cognitive impairment across different cognitive domains was found in individuals with fibromyalgia compared with healthy controls. Mood states (depression and anxiety) may explain the heterogeneity across studies.",
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T1 - Cognitive impairment in fibromyalgia

T2 - A meta-analysis of case-control studies

AU - Wu, Yu Lin

AU - Huang, Chun Jen

AU - Fang, Su Chen

AU - Ko, Ling Hsin

AU - Tsai, Pei Shan

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Objective Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological tests have been inconsistent. The aim of the study was to determine domain-specific cognitive impairment in patients with fibromyalgia compared with healthy controls. Methods We conducted a meta-analysis that systematically searched six databases (PubMed, Ovid MEDLINE, Embase, CINAHL, PsycINFO, and Web of Science) for articles published before September 2017. Results Twenty-three case-control studies with a total of 2096 participants were included in the meta-analysis. Cognitive function was significantly lower (g = 0.87, 95% confidence interval [CI] = 0.60-1.15) in individuals with fibromyalgia than in healthy controls. Large effect sizes were found in learning/memory and attention/psychomotor speed (g = 0.94, p =.013; g = 1.22, p <.001, respectively); medium effect sizes were reported in executive function and working memory (g = 0.72, p <.001; g = 0.75, p <.001, respectively). Depression and anxiety scores were associated with the effect size of group differences in cognitive function (B = 0.11, p <.001, 95% CI = 0.09-0.13; B = 0.02, p <.001, 95% CI = 0.01-0.02, respectively). Conclusions Cognitive impairment across different cognitive domains was found in individuals with fibromyalgia compared with healthy controls. Mood states (depression and anxiety) may explain the heterogeneity across studies.

AB - Objective Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological tests have been inconsistent. The aim of the study was to determine domain-specific cognitive impairment in patients with fibromyalgia compared with healthy controls. Methods We conducted a meta-analysis that systematically searched six databases (PubMed, Ovid MEDLINE, Embase, CINAHL, PsycINFO, and Web of Science) for articles published before September 2017. Results Twenty-three case-control studies with a total of 2096 participants were included in the meta-analysis. Cognitive function was significantly lower (g = 0.87, 95% confidence interval [CI] = 0.60-1.15) in individuals with fibromyalgia than in healthy controls. Large effect sizes were found in learning/memory and attention/psychomotor speed (g = 0.94, p =.013; g = 1.22, p <.001, respectively); medium effect sizes were reported in executive function and working memory (g = 0.72, p <.001; g = 0.75, p <.001, respectively). Depression and anxiety scores were associated with the effect size of group differences in cognitive function (B = 0.11, p <.001, 95% CI = 0.09-0.13; B = 0.02, p <.001, 95% CI = 0.01-0.02, respectively). Conclusions Cognitive impairment across different cognitive domains was found in individuals with fibromyalgia compared with healthy controls. Mood states (depression and anxiety) may explain the heterogeneity across studies.

KW - ACR = American College of Rheumatology

KW - ACT = Auditory Consonant Trigram

KW - BAI = Beck Anxiety Inventory

KW - BDI = Beck Depression Inventory

KW - BSI = Brief Symptom Inventory

KW - Cognitive function

KW - Fibromyalgia

KW - Meta-analysis

KW - Pain

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