Coagulation activation in Type 2 diabetes mellitus the higher coronary risk of female diabetic patients

P. Chan, W. H. Pan

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Thrombophilia in diabetic patients is a well-recognized phenomenon which constitutes an additional risk of coronary heart disease. This study included 1980 ethnic Chinese people (835 male, 1145 female); age range: 45 to 69 years, including 280 Type 2 diabetic patients (male 125, female 155). Haemostatic parameters measured were fibrinogen, prothrombin time, activated partial thromboplastin time (APTT), factor VIIc, factor VIIIc, antithrombin III, and plasminogen. Compared with a control group, male diabetic patients showed significantly shorter APTT (25.6 ± 3.7 vs 27.5 ± 3.6 s, p <0.01), and elevated factor VIIIc (171.1 ± 77.48 vs 131.16 ± 52.23%, p <0.0001), whereas female diabetic patients showed significantly shorter APTT (24.9 ± 4.2 vs 26.5 ± 3.9 s, p <0.001) and elevated fibrinogen (10.6 ± 3.3 vs 9.8 ± 2.6 μmol 1-1, p

Original languageEnglish
Pages (from-to)504-507
Number of pages4
JournalDiabetic Medicine
Volume12
Issue number6
Publication statusPublished - 1995
Externally publishedYes

Keywords

  • Coagulation
  • Coronary risk factor
  • Type 2 diabetes mellitis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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