Cluster headache is associated with an increased risk of depression: A nationwide population-based cohort study

Jen Feng Liang, Yung Tai Chen, Jong Ling Fuh, Szu Yuan Li, Chia Jen Liu, Tzeng Ji Chen, Chao Hsiun Tang, Shuu Jiun Wang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: To investigate whether cluster headache (CH) was a risk factor for depression in a nationwide population-based follow-up study. Background: There are few studies about the relationship between CH and depression, and prior research has been limited by cross-sectional studies or small sample sizes. Methods: We identified 673 CH patients from the Taiwan National Health Insurance database between 2005 and 2009. The two comparison cohorts included age-, sex- and Charlsons score-matched migraine patients (n=2692) and controls (patients free from migraine or CH, n=2692). The cumulative incidence of depression was compared among these three cohorts until the end of 2009. We also calculated predictors of depression in the CH cohort. Results: After the median 2.5-year follow-up duration, the CH cohort had a greater risk for developing depression compared to the control cohort (adjusted hazard ratio; aHR=5.6, 95% CI 3.0-10.6, p

Original languageEnglish
Pages (from-to)182-189
Number of pages8
JournalCephalalgia
Volume33
Issue number3
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Cluster headache
  • depression
  • incidence
  • migraine
  • risk
  • Taiwan

ASJC Scopus subject areas

  • Clinical Neurology

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    Liang, J. F., Chen, Y. T., Fuh, J. L., Li, S. Y., Liu, C. J., Chen, T. J., Tang, C. H., & Wang, S. J. (2013). Cluster headache is associated with an increased risk of depression: A nationwide population-based cohort study. Cephalalgia, 33(3), 182-189. https://doi.org/10.1177/0333102412469738