Clinicopathologic factors related to apoptosis in retinoblastoma

A. G. Wang, C. R. Lai, Wen-Ming Hsu, J. H. Liu, M. Y. Yen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To investigate the presence of apoptosis in retinoblastoma and its correlation with other pathologic and prognostic factors. Methods: The pathologic and admission records of 25 patients with a pathologically confirmed diagnosis of retinoblastoma were reviewed. TUNEL (TdT dUTP nick end labeling) staining was used to examine apoptosis in the pathologic slides of these 25 patients. The association between apoptosis and clinicopathologic factors was examined with chi-square, Fisher's exact, and Student's t tests. Results: Of the 25 specimens tested, 11 were TUNEL stain-positive for the presence of apoptotic cells. Apoptosis was found more frequently in younger patients and within rosettes, although these associations were not statistically significant. Apoptosis was not associated with tumor invasion or metastasis. Conclusion: Apoptotic cells were found in 11 of 25 retinoblastoma specimens. Apoptosis tends to occur in young patients and be distributed within rosettes.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalJournal of Pediatric Ophthalmology and Strabismus
Volume38
Issue number5
Publication statusPublished - Oct 1 2001
Externally publishedYes

Fingerprint

Retinoblastoma
Apoptosis
Coloring Agents
Staining and Labeling
Students
Neoplasm Metastasis
Neoplasms

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology

Cite this

Clinicopathologic factors related to apoptosis in retinoblastoma. / Wang, A. G.; Lai, C. R.; Hsu, Wen-Ming; Liu, J. H.; Yen, M. Y.

In: Journal of Pediatric Ophthalmology and Strabismus, Vol. 38, No. 5, 01.10.2001, p. 295-301.

Research output: Contribution to journalArticle

Wang, A. G. ; Lai, C. R. ; Hsu, Wen-Ming ; Liu, J. H. ; Yen, M. Y. / Clinicopathologic factors related to apoptosis in retinoblastoma. In: Journal of Pediatric Ophthalmology and Strabismus. 2001 ; Vol. 38, No. 5. pp. 295-301.
@article{524a18d28ee4439887e0ee6d2f426064,
title = "Clinicopathologic factors related to apoptosis in retinoblastoma",
abstract = "Purpose: To investigate the presence of apoptosis in retinoblastoma and its correlation with other pathologic and prognostic factors. Methods: The pathologic and admission records of 25 patients with a pathologically confirmed diagnosis of retinoblastoma were reviewed. TUNEL (TdT dUTP nick end labeling) staining was used to examine apoptosis in the pathologic slides of these 25 patients. The association between apoptosis and clinicopathologic factors was examined with chi-square, Fisher's exact, and Student's t tests. Results: Of the 25 specimens tested, 11 were TUNEL stain-positive for the presence of apoptotic cells. Apoptosis was found more frequently in younger patients and within rosettes, although these associations were not statistically significant. Apoptosis was not associated with tumor invasion or metastasis. Conclusion: Apoptotic cells were found in 11 of 25 retinoblastoma specimens. Apoptosis tends to occur in young patients and be distributed within rosettes.",
author = "Wang, {A. G.} and Lai, {C. R.} and Wen-Ming Hsu and Liu, {J. H.} and Yen, {M. Y.}",
year = "2001",
month = "10",
day = "1",
language = "English",
volume = "38",
pages = "295--301",
journal = "Journal of Pediatric Ophthalmology and Strabismus",
issn = "0191-3913",
publisher = "Slack Incorporated",
number = "5",

}

TY - JOUR

T1 - Clinicopathologic factors related to apoptosis in retinoblastoma

AU - Wang, A. G.

AU - Lai, C. R.

AU - Hsu, Wen-Ming

AU - Liu, J. H.

AU - Yen, M. Y.

PY - 2001/10/1

Y1 - 2001/10/1

N2 - Purpose: To investigate the presence of apoptosis in retinoblastoma and its correlation with other pathologic and prognostic factors. Methods: The pathologic and admission records of 25 patients with a pathologically confirmed diagnosis of retinoblastoma were reviewed. TUNEL (TdT dUTP nick end labeling) staining was used to examine apoptosis in the pathologic slides of these 25 patients. The association between apoptosis and clinicopathologic factors was examined with chi-square, Fisher's exact, and Student's t tests. Results: Of the 25 specimens tested, 11 were TUNEL stain-positive for the presence of apoptotic cells. Apoptosis was found more frequently in younger patients and within rosettes, although these associations were not statistically significant. Apoptosis was not associated with tumor invasion or metastasis. Conclusion: Apoptotic cells were found in 11 of 25 retinoblastoma specimens. Apoptosis tends to occur in young patients and be distributed within rosettes.

AB - Purpose: To investigate the presence of apoptosis in retinoblastoma and its correlation with other pathologic and prognostic factors. Methods: The pathologic and admission records of 25 patients with a pathologically confirmed diagnosis of retinoblastoma were reviewed. TUNEL (TdT dUTP nick end labeling) staining was used to examine apoptosis in the pathologic slides of these 25 patients. The association between apoptosis and clinicopathologic factors was examined with chi-square, Fisher's exact, and Student's t tests. Results: Of the 25 specimens tested, 11 were TUNEL stain-positive for the presence of apoptotic cells. Apoptosis was found more frequently in younger patients and within rosettes, although these associations were not statistically significant. Apoptosis was not associated with tumor invasion or metastasis. Conclusion: Apoptotic cells were found in 11 of 25 retinoblastoma specimens. Apoptosis tends to occur in young patients and be distributed within rosettes.

UR - http://www.scopus.com/inward/record.url?scp=0034838136&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034838136&partnerID=8YFLogxK

M3 - Article

VL - 38

SP - 295

EP - 301

JO - Journal of Pediatric Ophthalmology and Strabismus

JF - Journal of Pediatric Ophthalmology and Strabismus

SN - 0191-3913

IS - 5

ER -