Clinical use of single-dose surfactant TA therapy for premature infants with severe respiratory distress syndrome.

H. H. Deng, M. C. Kuo, K. H. Chung, Hsun-Hui Hsu, S. T. Lin

Research output: Contribution to journalArticle

Abstract

A single dose of surfactant TA was given as rescue therapy to four small premature infants with severe respiratory distress syndrome requiring mechanical ventilation. Birth weights ranged from 810 to 1200 gm. The dose of 100-120 mg/kg was given at the mean age of 5 hours, with range of 3 to 7 hours. Following surfactant therapy, there was a significant improvement (p <0.05) in a/APO2 (raising from 0.11 +/- 0.05 before treatment to 0.34 +/- 0.19 at 6 hours after treatment). There was also a significant reduction in the severity of respiratory distress syndrome at 24 hours post-therapy. One baby died of sepsis at 40 hours of life; one survived without complications. The other two cases developed severe bronchopulmonary dysplasia later. We concluded that early use of exogenous surfactant is beneficial in small premature infants with severe respiratory distress syndrome.

Original languageEnglish
Pages (from-to)408-416
Number of pages9
JournalActa Paediatrica Sinica
Volume33
Issue number6
Publication statusPublished - Nov 1992

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Premature Infants
Surface-Active Agents
Therapeutics
Bronchopulmonary Dysplasia
Artificial Respiration
Birth Weight
Sepsis
beractant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Clinical use of single-dose surfactant TA therapy for premature infants with severe respiratory distress syndrome. / Deng, H. H.; Kuo, M. C.; Chung, K. H.; Hsu, Hsun-Hui; Lin, S. T.

In: Acta Paediatrica Sinica, Vol. 33, No. 6, 11.1992, p. 408-416.

Research output: Contribution to journalArticle

Deng, H. H. ; Kuo, M. C. ; Chung, K. H. ; Hsu, Hsun-Hui ; Lin, S. T. / Clinical use of single-dose surfactant TA therapy for premature infants with severe respiratory distress syndrome. In: Acta Paediatrica Sinica. 1992 ; Vol. 33, No. 6. pp. 408-416.
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