Clinical significance of intratumoral blood flow in cervical carcinoma assessed by color doppler ultrasound

Chang‐Yao ‐Y Hsieh, Chih‐Cheng ‐C Wu, Tzer‐Ming ‐M Chen, Chi‐An ‐A Chen, Chi‐Long ‐L Chen, Jin‐Fei ‐F Wang, Chin‐Feng ‐F Chang, Fon‐Jou ‐J Hsieh

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Abstract

Background. Much evidence has suggested that vascular density reflects the clinical behavior of cancer. In this study, the intratumoral blood flow in cervical carcinomas was assessed by transvaginal color Doppler ultrasound, and its clinical significance was evaluated. Methods. Sixty‐five patients with Stage Ib‐IIb cervical carcinoma exhibiting visible cervical tumor by trans‐vaginal ultrasound were enrolled. All patients were scheduled for radical hysterectomy and pelvic lymph node dissection. Transvaginal color Doppler ultrasound was performed before surgery to search for blood flow signals tumor and the main uterine artery. The corresponding arterial resistance index (RI) was calculated. Clinical and pathologic data were recorded. A cyto‐kinetic study was performed by propidium iodide staining and flow cytometry. The human papillomavirus (HPV) status was assessed by polymerase chain reaction. Results. Intratumoral blood flow was detected by color Doppler ultrasound in 46.2% (30/65) of the tumors. Patients with detectable intratumoral blood flow exhibited significantly more pelvic lymph node metastasis (10/30 vs. 2/35, P = 0.005), a higher percentage of cancer cells in the S‐ + G2M‐phase (30.02±18.54% vs. 19.35±11.21%, P < 0.005), and a higher prevalence of HPV infection (30/ 30 vs. 25/35, P = 0.001) when compared with those without intratumoral blood flow. No significant difference was observed concerning the patient's age, tumor size, clinical staging, histologic type, and DNA ploidy status between these two groups. Regression analysis of the showed linear regression (n = 30, r2 = 0.501, P < 0.01). The RI values of the main uterine artery showed no significant difference between these two groups. Conclusion. The intratumoral blood flow by transvaginal color Doppler ultrasound correlated well with a higher proliferation index, higher incidence of HPV infection, and pelvic lymph node metastasis in cervical carcinoma.

Original languageEnglish
Pages (from-to)2518-2522
Number of pages5
JournalCancer
Volume75
Issue number10
DOIs
Publication statusPublished - 1995
Externally publishedYes

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Doppler Ultrasonography
Color
Carcinoma
Uterine Artery
Neoplasms
Papillomavirus Infections
Lymph Nodes
Neoplasm Metastasis
Propidium
Ploidies
Lymph Node Excision
Hysterectomy
Blood Vessels
Linear Models
Flow Cytometry
Regression Analysis
Staining and Labeling
Polymerase Chain Reaction
DNA
Incidence

Keywords

  • cervical carcinoma
  • color Doppler ultrasound
  • cytokinetics
  • human papillomavirus
  • metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Clinical significance of intratumoral blood flow in cervical carcinoma assessed by color doppler ultrasound. / Hsieh, Chang‐Yao ‐Y; Wu, Chih‐Cheng ‐C; Chen, Tzer‐Ming ‐M; Chen, Chi‐An ‐A; Chen, Chi‐Long ‐L; Wang, Jin‐Fei ‐F; Chang, Chin‐Feng ‐F; Hsieh, Fon‐Jou ‐J.

In: Cancer, Vol. 75, No. 10, 1995, p. 2518-2522.

Research output: Contribution to journalArticle

Hsieh, Chang‐Yao ‐Y ; Wu, Chih‐Cheng ‐C ; Chen, Tzer‐Ming ‐M ; Chen, Chi‐An ‐A ; Chen, Chi‐Long ‐L ; Wang, Jin‐Fei ‐F ; Chang, Chin‐Feng ‐F ; Hsieh, Fon‐Jou ‐J. / Clinical significance of intratumoral blood flow in cervical carcinoma assessed by color doppler ultrasound. In: Cancer. 1995 ; Vol. 75, No. 10. pp. 2518-2522.
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abstract = "Background. Much evidence has suggested that vascular density reflects the clinical behavior of cancer. In this study, the intratumoral blood flow in cervical carcinomas was assessed by transvaginal color Doppler ultrasound, and its clinical significance was evaluated. Methods. Sixty‐five patients with Stage Ib‐IIb cervical carcinoma exhibiting visible cervical tumor by trans‐vaginal ultrasound were enrolled. All patients were scheduled for radical hysterectomy and pelvic lymph node dissection. Transvaginal color Doppler ultrasound was performed before surgery to search for blood flow signals tumor and the main uterine artery. The corresponding arterial resistance index (RI) was calculated. Clinical and pathologic data were recorded. A cyto‐kinetic study was performed by propidium iodide staining and flow cytometry. The human papillomavirus (HPV) status was assessed by polymerase chain reaction. Results. Intratumoral blood flow was detected by color Doppler ultrasound in 46.2{\%} (30/65) of the tumors. Patients with detectable intratumoral blood flow exhibited significantly more pelvic lymph node metastasis (10/30 vs. 2/35, P = 0.005), a higher percentage of cancer cells in the S‐ + G2M‐phase (30.02±18.54{\%} vs. 19.35±11.21{\%}, P < 0.005), and a higher prevalence of HPV infection (30/ 30 vs. 25/35, P = 0.001) when compared with those without intratumoral blood flow. No significant difference was observed concerning the patient's age, tumor size, clinical staging, histologic type, and DNA ploidy status between these two groups. Regression analysis of the showed linear regression (n = 30, r2 = 0.501, P < 0.01). The RI values of the main uterine artery showed no significant difference between these two groups. Conclusion. The intratumoral blood flow by transvaginal color Doppler ultrasound correlated well with a higher proliferation index, higher incidence of HPV infection, and pelvic lymph node metastasis in cervical carcinoma.",
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AU - Chen, Chi‐An ‐A

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N2 - Background. Much evidence has suggested that vascular density reflects the clinical behavior of cancer. In this study, the intratumoral blood flow in cervical carcinomas was assessed by transvaginal color Doppler ultrasound, and its clinical significance was evaluated. Methods. Sixty‐five patients with Stage Ib‐IIb cervical carcinoma exhibiting visible cervical tumor by trans‐vaginal ultrasound were enrolled. All patients were scheduled for radical hysterectomy and pelvic lymph node dissection. Transvaginal color Doppler ultrasound was performed before surgery to search for blood flow signals tumor and the main uterine artery. The corresponding arterial resistance index (RI) was calculated. Clinical and pathologic data were recorded. A cyto‐kinetic study was performed by propidium iodide staining and flow cytometry. The human papillomavirus (HPV) status was assessed by polymerase chain reaction. Results. Intratumoral blood flow was detected by color Doppler ultrasound in 46.2% (30/65) of the tumors. Patients with detectable intratumoral blood flow exhibited significantly more pelvic lymph node metastasis (10/30 vs. 2/35, P = 0.005), a higher percentage of cancer cells in the S‐ + G2M‐phase (30.02±18.54% vs. 19.35±11.21%, P < 0.005), and a higher prevalence of HPV infection (30/ 30 vs. 25/35, P = 0.001) when compared with those without intratumoral blood flow. No significant difference was observed concerning the patient's age, tumor size, clinical staging, histologic type, and DNA ploidy status between these two groups. Regression analysis of the showed linear regression (n = 30, r2 = 0.501, P < 0.01). The RI values of the main uterine artery showed no significant difference between these two groups. Conclusion. The intratumoral blood flow by transvaginal color Doppler ultrasound correlated well with a higher proliferation index, higher incidence of HPV infection, and pelvic lymph node metastasis in cervical carcinoma.

AB - Background. Much evidence has suggested that vascular density reflects the clinical behavior of cancer. In this study, the intratumoral blood flow in cervical carcinomas was assessed by transvaginal color Doppler ultrasound, and its clinical significance was evaluated. Methods. Sixty‐five patients with Stage Ib‐IIb cervical carcinoma exhibiting visible cervical tumor by trans‐vaginal ultrasound were enrolled. All patients were scheduled for radical hysterectomy and pelvic lymph node dissection. Transvaginal color Doppler ultrasound was performed before surgery to search for blood flow signals tumor and the main uterine artery. The corresponding arterial resistance index (RI) was calculated. Clinical and pathologic data were recorded. A cyto‐kinetic study was performed by propidium iodide staining and flow cytometry. The human papillomavirus (HPV) status was assessed by polymerase chain reaction. Results. Intratumoral blood flow was detected by color Doppler ultrasound in 46.2% (30/65) of the tumors. Patients with detectable intratumoral blood flow exhibited significantly more pelvic lymph node metastasis (10/30 vs. 2/35, P = 0.005), a higher percentage of cancer cells in the S‐ + G2M‐phase (30.02±18.54% vs. 19.35±11.21%, P < 0.005), and a higher prevalence of HPV infection (30/ 30 vs. 25/35, P = 0.001) when compared with those without intratumoral blood flow. No significant difference was observed concerning the patient's age, tumor size, clinical staging, histologic type, and DNA ploidy status between these two groups. Regression analysis of the showed linear regression (n = 30, r2 = 0.501, P < 0.01). The RI values of the main uterine artery showed no significant difference between these two groups. Conclusion. The intratumoral blood flow by transvaginal color Doppler ultrasound correlated well with a higher proliferation index, higher incidence of HPV infection, and pelvic lymph node metastasis in cervical carcinoma.

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