Clinical significance of interleukin-6 and interleukin-6 receptor expressions in oral squamous cell carcinoma

Yi Fen Wang, Shyue Yih Chang, Shyh Kuan Tai, Wing Yin Li, Liang Shun Wang

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background. Recent studies showed that interleukin-6 (IL-6) played a role in tumor development. However, available information about the prognostic significance of IL-6 and IL-6 receptors (IL-6R) for oral squamous cell carcinoma (OSCC) is limited. Methods. Eighty-six patients with OSCC were enrolled. Immunohistochemical staining was used to determine IL-6R expression and in-situ hybridization for IL-6 mRNA transcripts in surgical specimens. Clinicopathologic correlation was evaluated by chi-square test and survival by log rank test. Results. Expression rates of IL-6R and IL-6 mRNA transcripts in tumor specimens were 73.3% and 54.7%, much higher than those in nontumor mucosa (p <.001). IL-6R overexpression was associated with larger tumors and more advanced histologic grade (p <.05). The presence of IL-6 mRNA transcripts was inversely correlated with distant metastasis, lymph node involvement, and second primary SCC (p <.05) and predicted better survival (p = .007). Conclusions. IL-6-IL-6R coexpression was rather high in OSCC, and IL-6 mRNA transcript expression might influence patient survival. The biologic role of IL-6-IL-6R coexpression in OSCC needs additional investigation.

Original languageEnglish
Pages (from-to)850-858
Number of pages9
JournalHead and Neck
Volume24
Issue number9
DOIs
Publication statusPublished - Sep 2002
Externally publishedYes

Fingerprint

Interleukin-6 Receptors
Squamous Cell Carcinoma
Interleukin-6
Messenger RNA
Survival
Neoplasms
Chi-Square Distribution
In Situ Hybridization
Mucous Membrane
Lymph Nodes
Staining and Labeling
Neoplasm Metastasis

Keywords

  • Interleukin-6
  • Interleukin-6 receptor
  • Oral squamous cell carcinoma
  • Prognosis

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Clinical significance of interleukin-6 and interleukin-6 receptor expressions in oral squamous cell carcinoma. / Wang, Yi Fen; Chang, Shyue Yih; Tai, Shyh Kuan; Li, Wing Yin; Wang, Liang Shun.

In: Head and Neck, Vol. 24, No. 9, 09.2002, p. 850-858.

Research output: Contribution to journalArticle

Wang, Yi Fen ; Chang, Shyue Yih ; Tai, Shyh Kuan ; Li, Wing Yin ; Wang, Liang Shun. / Clinical significance of interleukin-6 and interleukin-6 receptor expressions in oral squamous cell carcinoma. In: Head and Neck. 2002 ; Vol. 24, No. 9. pp. 850-858.
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