Clinical predictors of the response to short-term thiazide treatment in nondiabetic essential hypertensives

C. C. Huang, H. B. Leu, T. C. Wu, S. J. Lin, J. W. Chen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Blood pressure (BP) response to diuretics is varied in hypertensive patients. This study aimed to identify the patients who may respond better or worse to thiazide diuretics. Nondiabetic patients with treated or untreated hypertension were evaluated if they did not take diuretics and their office systolic BP (SBP) >140 mmHg or diastolic BP (DBP) >90 mmHg. Diet and life style modification were advised in addition to the concomitant medication, if there were, for 2 weeks. Additional hydrochlorothiazide 50 mg was given per day for another 2 weeks. Both office and 24-h ambulatory BP were checked. The changes of office SBP were used for the response to thiazide treatment. A total of 92 patients were enrolled. Compared with those in the quartile of worst response, patients in the quartile of best response were older with increased baseline SBP and pulse pressure (PP) and reduced heart rate. Reduced baseline awake, but not increased sleep DBP was associated with better response to thiazide. Besides, baseline age, SBP and PP were correlated to the response to thiazide treatment. Among these variables, increased baseline mean BP independently predicted the best and reduced SBP predicted the worst responders. Accordingly, patients with higher mean BP respond better to thiazide treatment no matter with or without concomitant medication. Patients with mainly diastolic hypertension with lower SBP responded poorly to thiazide treatment. The findings may help to individualized use of thiazide in nondiabetic hypertensives.

Original languageEnglish
Pages (from-to)329-337
Number of pages9
JournalJournal of Human Hypertension
Volume22
Issue number5
DOIs
Publication statusPublished - May 2008
Externally publishedYes

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Thiazides
Blood Pressure
Therapeutics
Hypertension
Diuretics
Sodium Chloride Symporter Inhibitors
Hydrochlorothiazide
Life Style
Sleep
Heart Rate

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Clinical predictors of the response to short-term thiazide treatment in nondiabetic essential hypertensives. / Huang, C. C.; Leu, H. B.; Wu, T. C.; Lin, S. J.; Chen, J. W.

In: Journal of Human Hypertension, Vol. 22, No. 5, 05.2008, p. 329-337.

Research output: Contribution to journalArticle

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