Clinical pharmacology of angiotensin II type 1 receptor antagonists

Paul Chan, G. Neil Thomas, Yi Jen Chen, Brian Tomlinson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The angiotensin II type 1 receptor antagonists are the latest class of antihypertensive agents to be approved for treatment of hypertension. They have a similar efficacy in lowering blood pressure as other classes of antihypertensive agents. The blood pressure-lowering effect is potentiated when given concomitantly with low-dose thiazide diuretics. These agents are well-tolerated, with an incidence of adverse effects similar to that of placebo and significantly lower than experienced with the other class of renin-angiotensin system antagonists, the angiotensin-converting enzyme inhibitors. Dose adjustments are often not necessary in patients with renal or hepatic insufficiency or in the elderly. In summary, these agents are efficacious for blood pressure lowering with a single daily dose.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalActa Cardiologica Sinica
Volume18
Issue number1
Publication statusPublished - 2002

Fingerprint

Angiotensin II Type 1 Receptor Blockers
Clinical Pharmacology
Blood Pressure
Antihypertensive Agents
Hepatic Insufficiency
Sodium Chloride Symporter Inhibitors
Renin-Angiotensin System
Angiotensin-Converting Enzyme Inhibitors
Renal Insufficiency
Placebos
Hypertension
Incidence
Therapeutics

Keywords

  • Angiotensin II type 1 receptor antagonists
  • Angiotensin-converting enzyme
  • Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Clinical pharmacology of angiotensin II type 1 receptor antagonists. / Chan, Paul; Thomas, G. Neil; Chen, Yi Jen; Tomlinson, Brian.

In: Acta Cardiologica Sinica, Vol. 18, No. 1, 2002, p. 1-10.

Research output: Contribution to journalArticle

Chan, Paul ; Thomas, G. Neil ; Chen, Yi Jen ; Tomlinson, Brian. / Clinical pharmacology of angiotensin II type 1 receptor antagonists. In: Acta Cardiologica Sinica. 2002 ; Vol. 18, No. 1. pp. 1-10.
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