Clinical outcome of very late recurrence of atrial fibrillation after catheter ablation of paroxysmal atrial fibrillation

Ming Hsiung Hsieh, Ching Tai Tai, Chin Feng Tsai, Wei Shiang Lin, Yung Kuo Lin, Hsuan Ming Tsao, Jin Long Huang, Kwo Chang Ueng, Wen Chung Yu, Paul Chan, Yu An Ding, Mau Song Chang, Shih Ann Chen

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)


Very Late Recurrence of AF. Introduction: High recurrence rate is still a major problem associated with ablation of paroxysmal atrial fibrillation (AF). Most of the recurrences occur within 6 months after ablation. The characteristics of very late recurrent AF (> 12 months after ablation) have not been reported. Methods and Results: Two hundred seven patients with drug-refractory AF underwent successful focal ablation or isolation of AF loci. After the first ablation procedure, Holter monitoring and event recorders were used to evaluate symptomatic recurrent AF. A second ablation procedure was recommended if the antiarrhythmic drugs could not control recurrent AF. During long-term follow-up (mean 30 ± 11 months, up to 51 months), 70 patients had recurrent AF, including 13 patients (6%) with very late (>12 months) recurrent AF (group 1) and 57 patients (28%) with late (within 12 months after ablation) recurrent AF(group 2). Group 1 patients had a significantly lower incidence of multiple (≥2) AF foci (23% vs 63%, P = 0.02) than group 2 patients. In addition, the incidence of antiarrhythmic drugs use (38% vs 84%, P = 0.001) to maintain sinus rhythm after the first episode of recurrent AF was significantly lower in group 1 than group 2 patients, and the incidence of a second intervention procedure (8% vs 35%, P = 0.051) tended to be lower in group 1 than group 2 patients. Conclusion: The incidence of very late recurrent AF after ablation of paroxysmal AF is very low, and the clinical outcome of patients with very late recurrent AF is benign.

Original languageEnglish
Pages (from-to)598-601
Number of pages4
JournalJournal of Cardiovascular Electrophysiology
Issue number6
Publication statusPublished - Jun 1 2003
Externally publishedYes


  • Paroxysmal atrial fibrillation
  • Radiofrequency catheter ablation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

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