Clinical observation of meningitis caused by penicilin-susceptible and -non-susceptible Streptococcus pneumoniae in Taiwanese children

Shih Hsiang Chen, Meng Hsiu Yen, Cheng Hsun Chiu, Dah Chin Yan, Chih Yi Hsu, Tzou Yien Lin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: To compare differences between clinical features and outcome in bacterial meningitis caused by penicillin-susceptible Streproroccus pneumoniae (PSSP) with that caused by penicillin-non-susceptible Streptococcus pneumoniae (PNSP). Methods: All patients < 18 yrs hospitalised with pneumococcal meningitis between January 1984 and December 2002 at Chang Gung Children's Hospital, Taipei were reviewed retrospectively. Results: There were 28 PNSP (63.6%) and 16 PSSP cases of meningitis eligible for the study. The incidence of PNSP meningitis increased significantly over the 8-yr period (p=0.007). Age <4 yrs (78.6% vs 50%), a lower initial white blood count (mean 11.7 vs 19.9 × 109/L), admission to the intensive care unit (70.4% vs 50%) and mortality (28.6% vs 6.3%) were more common in the PNSP group. However, the only significant finding was a lower proportion of polymorphic neutrophils in the CSF of the PNSP meningitis group (p=0.04). Conclusions: There was an increase in PNSP isolates from patients with meningitis over the 8-yr study period. No major differences were observed in clinical or laboratory features or outcome between the PSSP and PNSP group.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalAnnals of Tropical Paediatrics
Volume26
Issue number3
DOIs
Publication statusPublished - Sep 2006
Externally publishedYes

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Streptococcus pneumoniae
Meningitis
Penicillins
Observation
Pneumococcal Meningitis
Pneumonia
Bacterial Meningitides
Intensive Care Units
Neutrophils
Mortality
Incidence

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Clinical observation of meningitis caused by penicilin-susceptible and -non-susceptible Streptococcus pneumoniae in Taiwanese children. / Chen, Shih Hsiang; Yen, Meng Hsiu; Chiu, Cheng Hsun; Yan, Dah Chin; Hsu, Chih Yi; Lin, Tzou Yien.

In: Annals of Tropical Paediatrics, Vol. 26, No. 3, 09.2006, p. 181-185.

Research output: Contribution to journalArticle

Chen, Shih Hsiang ; Yen, Meng Hsiu ; Chiu, Cheng Hsun ; Yan, Dah Chin ; Hsu, Chih Yi ; Lin, Tzou Yien. / Clinical observation of meningitis caused by penicilin-susceptible and -non-susceptible Streptococcus pneumoniae in Taiwanese children. In: Annals of Tropical Paediatrics. 2006 ; Vol. 26, No. 3. pp. 181-185.
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