Clinical manifestations of strongyloidiasis in southern Taiwan

Hung Chin Tsai, Susan Shin Jung Lee, Yung Ching Liu, Wei Ru Lin, Chun Kai Huang, Yao Shen Chen, Shue Ren Wann, Tsung Hung Tsai, Hsi Hsun Lin, Muh Yong Yen, Chuan Min Yen, Eng Rin Chen

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The diagnosis and management of strongyloidiasis present a continuous challenge in developing countries including Taiwan. In this study, the clinical characteristics and microbiological findings of 27 patients with Strongyloides stercoralis infection were retrospectively analyzed. Intestinal infection was identified in 17 patients and hyperinfection syndrome or disseminated disease in 10 (including 2 autopsy cases). The most frequent clinical findings were diarrhea (74%), fever (70%), abdominal pain (59%), cough (37%), dyspnea (33%), and constipation (26%). The common initial laboratory abnormalities were leukocytosis (81%), anemia (67%), liver function impairment (52%), and eosinophilia (44%). Most of the 27 patients had comorbid conditions, including malnutrition in 20 (74%), corticosteroid dependence in 15 (55%), chronic obstructive pulmonary disease in 9 (33%), chronic liver disease or cirrhosis in 8 (30%), and peptic ulcer disease in 7 (26%). There was no difference in the time interval from symptom onset to diagnosis between the intestinal infection group and the hyperinfection/disseminated group (22 ± 15 vs 17 ± 9 days). Larvae of S. stercoralis were identified in the stool of 24 patients, in the sputum smear of 5, in the gastric biopsy of one, and on histology of autopsy specimens in 2. Twenty-six patients received antiparasitic drug therapy of variable duration (mebendazole in 24, albendazole in 2, combined therapy in one). The overall cure rate was 52% (14/27). Relapse occurred in 4 patients. The overall mortality was 26% (7/27). There was a high mortality (up to 50%) in the hyperinfection/disseminated disease group. In conclusion, diagnosis of strongyloidiasis is often delayed and overlooked because of nonspecific symptoms. Physicians in endemic regions should include strongyloidiasis in the differential diagnosis when patients present with gastrointestinal and/or pulmonary symptoms with peripheral eosinophilia.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalJournal of Microbiology, Immunology and Infection
Volume35
Issue number1
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Strongyloidiasis
Taiwan
Strongyloides stercoralis
Eosinophilia
Autopsy
Infection
Mebendazole
Antiparasitic Agents
Albendazole
Mortality
Leukocytosis
Constipation
Sputum
Peptic Ulcer
Cough
Malnutrition
Liver Cirrhosis
Dyspnea
Chronic Obstructive Pulmonary Disease
Abdominal Pain

Keywords

  • Hyperinfection syndrome
  • Strongyloides stercoralis
  • Strongyloidiasis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)

Cite this

Tsai, H. C., Lee, S. S. J., Liu, Y. C., Lin, W. R., Huang, C. K., Chen, Y. S., ... Chen, E. R. (2002). Clinical manifestations of strongyloidiasis in southern Taiwan. Journal of Microbiology, Immunology and Infection, 35(1), 29-36.

Clinical manifestations of strongyloidiasis in southern Taiwan. / Tsai, Hung Chin; Lee, Susan Shin Jung; Liu, Yung Ching; Lin, Wei Ru; Huang, Chun Kai; Chen, Yao Shen; Wann, Shue Ren; Tsai, Tsung Hung; Lin, Hsi Hsun; Yen, Muh Yong; Yen, Chuan Min; Chen, Eng Rin.

In: Journal of Microbiology, Immunology and Infection, Vol. 35, No. 1, 2002, p. 29-36.

Research output: Contribution to journalArticle

Tsai, HC, Lee, SSJ, Liu, YC, Lin, WR, Huang, CK, Chen, YS, Wann, SR, Tsai, TH, Lin, HH, Yen, MY, Yen, CM & Chen, ER 2002, 'Clinical manifestations of strongyloidiasis in southern Taiwan', Journal of Microbiology, Immunology and Infection, vol. 35, no. 1, pp. 29-36.
Tsai, Hung Chin ; Lee, Susan Shin Jung ; Liu, Yung Ching ; Lin, Wei Ru ; Huang, Chun Kai ; Chen, Yao Shen ; Wann, Shue Ren ; Tsai, Tsung Hung ; Lin, Hsi Hsun ; Yen, Muh Yong ; Yen, Chuan Min ; Chen, Eng Rin. / Clinical manifestations of strongyloidiasis in southern Taiwan. In: Journal of Microbiology, Immunology and Infection. 2002 ; Vol. 35, No. 1. pp. 29-36.
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