Clinical manifestations of actinomycosis in Southern Taiwan

Yung Hsing Wang, Hung Chin Tsai, Susan Shin Jung Lee, Ming Hsin Mai, Shue Ren Wann, Yao Shen Chen, Yung Ching Liu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background and Purpose: Actinomycosis is an uncommon and frequently misdiagnosed infection that may present as an acute or indolent process. Even when clinical suspicion is high, the disease is commonly confused with other chronic inflammatory diseases and malignancy. An early diagnosis helps the clinician in deciding treatment and can avoid physical morbidity such as unwarranted surgery. Methods: We retrospectively evaluated the histopathology and selected clinical information on all cases of actinomycosis that occurred at Kaohsiung Veterans General Hospital in Taiwan from 1993 to 2005. Data on the demographic characteristics, predisposing conditions, clinical presentations, diagnosis and treatment were analyzed. Results: A total 36 cases of actinomycosis were identified and evaluated. The mean age of patients was 52.14 ± 13.28 years, and the male-to-female ratio was 1:1.1. Only three types of actinomycosis were found in this study: cervicofacial, at an incidence of 31%; thoracic (33%); and pelvic (36%). The clinical manifestations depended upon the region of infection; the most frequent presentations of cervicofacial, thoracic and pelvic actinomycosis were cutaneous soft tissue swelling with drainage sinus formation (55%), hemotypsis (75%) and abnormal vaginal spotting (54%), respectively. The most common initial laboratory abnormalities were normochromic anemia (69%) and leukocytosis (25%). While most patients had no history of a foreign body, all pelvic actinomycotic patients had a history of intrauterine device use. Nineteen patients (53%) had no comorbid conditions and 11 patients (31%) had malignancy. Most patients were initially diagnosed as malignancy (56%). All patients with actinomycosis were diagnosed by histopathologic findings. Twenty two patients (61%) were treated by surgery combined with antibiotics, 11 patients (31%) by surgery only and 3 patients (8%) by antibiotics only. No recurrence or mortality occurred. Conclusions: Actinomycosis should be included in the differential diagnosis when patients present with chronic drainage sinus, chronic hemoptysis and abnormal vaginal spotting with use of intrauterine devices.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Volume40
Issue number6
Publication statusPublished - Dec 2007
Externally publishedYes

Fingerprint

Actinomycosis
Taiwan
Metrorrhagia
Intrauterine Devices
Drainage
Thorax
Anti-Bacterial Agents
Veterans Hospitals
Neoplasms
Hemoptysis
Leukocytosis
Foreign Bodies
Infection
Diagnostic Errors
General Hospitals
Anemia
Early Diagnosis
Differential Diagnosis
Chronic Disease
Demography

Keywords

  • Actinomyces
  • Actinomycosis
  • Chronic disease
  • Risk factors

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)

Cite this

Wang, Y. H., Tsai, H. C., Lee, S. S. J., Mai, M. H., Wann, S. R., Chen, Y. S., & Liu, Y. C. (2007). Clinical manifestations of actinomycosis in Southern Taiwan. Journal of Microbiology, Immunology and Infection, 40(6), 487-492.

Clinical manifestations of actinomycosis in Southern Taiwan. / Wang, Yung Hsing; Tsai, Hung Chin; Lee, Susan Shin Jung; Mai, Ming Hsin; Wann, Shue Ren; Chen, Yao Shen; Liu, Yung Ching.

In: Journal of Microbiology, Immunology and Infection, Vol. 40, No. 6, 12.2007, p. 487-492.

Research output: Contribution to journalArticle

Wang, YH, Tsai, HC, Lee, SSJ, Mai, MH, Wann, SR, Chen, YS & Liu, YC 2007, 'Clinical manifestations of actinomycosis in Southern Taiwan', Journal of Microbiology, Immunology and Infection, vol. 40, no. 6, pp. 487-492.
Wang YH, Tsai HC, Lee SSJ, Mai MH, Wann SR, Chen YS et al. Clinical manifestations of actinomycosis in Southern Taiwan. Journal of Microbiology, Immunology and Infection. 2007 Dec;40(6):487-492.
Wang, Yung Hsing ; Tsai, Hung Chin ; Lee, Susan Shin Jung ; Mai, Ming Hsin ; Wann, Shue Ren ; Chen, Yao Shen ; Liu, Yung Ching. / Clinical manifestations of actinomycosis in Southern Taiwan. In: Journal of Microbiology, Immunology and Infection. 2007 ; Vol. 40, No. 6. pp. 487-492.
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