Clinical features of radiologically confirmed pneumonia due to adenovirus in children

Shih Perng Chen, Yhu Chering Huang, Cheng Hsun Chiu, Kin Sun Wong, Ya Ling Huang, Chung Guei Huang, Kuo Chien Tsao, Tzou Yien Lin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Clinical features of radiologically confirmed pneumonia due to adenovirus in children have not been comprehensively evaluated. Objective: To describe the detailed clinical features of radiologically confirmed adenovirus-associated pneumonia in children. Study design: Of 3298 children with a throat virus culture positive for adenovirus treated at a university-affiliated hospital, from January 2000 to June 2008, in northern Taiwan, 80 hospitalized children (2.4%) with radiologically confirmed pneumonia were identified. From four children with incomplete medical records, only demographics were included for analysis. Results: The median age was 2.97. years, ranging from 25. days to 14. years. Seventy-three patients (96%) had fever, with a median duration of 7. days. The three most common respiratory symptoms were cough (99%), rhinorrhea (82%) and dyspnea (42%). Gastrointestinal symptoms were recorded in 80% of the patients, and neurologic symptoms in four children. Leukocytosis (WBC. ≥ 15,000/μL) was noted in 19 (25%) patients. Only six patients (8%) had a normal serum C-reactive protein (CRP) value (<5. mg/L), while 48 patients (63%) had a CRP level >40. mg/L. Seventeen (21%) children required intensive care. Seventy-three patients (96%) recovered uneventfully. Sequelae were seen in two patients and death in 1. Of the 69 isolates with serotyping determination, seven serotypes were identified, with a predominant serotype (type 3 for 73%). Conclusion: Less than 5% of the children with adenoviral infection had radiologically confirmed patch pneumonia. The manifestation of pneumonia caused by adenovirus was similar to that of bacterial pneumonia.

Original languageEnglish
Pages (from-to)7-12
Number of pages6
JournalJournal of Clinical Virology
Volume56
Issue number1
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

Fingerprint

Adenoviridae
Pneumonia
Bacterial Pneumonia
Serotyping
Hospitalized Child
Leukocytosis
Critical Care
Neurologic Manifestations
Pharynx
Taiwan
Cough
Dyspnea
C-Reactive Protein
Medical Records
Blood Proteins
Fever
Demography
Viruses
Infection

Keywords

  • Adenovirus
  • Children
  • Pneumonia

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Clinical features of radiologically confirmed pneumonia due to adenovirus in children. / Chen, Shih Perng; Huang, Yhu Chering; Chiu, Cheng Hsun; Wong, Kin Sun; Huang, Ya Ling; Huang, Chung Guei; Tsao, Kuo Chien; Lin, Tzou Yien.

In: Journal of Clinical Virology, Vol. 56, No. 1, 01.2013, p. 7-12.

Research output: Contribution to journalArticle

Chen, SP, Huang, YC, Chiu, CH, Wong, KS, Huang, YL, Huang, CG, Tsao, KC & Lin, TY 2013, 'Clinical features of radiologically confirmed pneumonia due to adenovirus in children', Journal of Clinical Virology, vol. 56, no. 1, pp. 7-12. https://doi.org/10.1016/j.jcv.2012.08.021
Chen, Shih Perng ; Huang, Yhu Chering ; Chiu, Cheng Hsun ; Wong, Kin Sun ; Huang, Ya Ling ; Huang, Chung Guei ; Tsao, Kuo Chien ; Lin, Tzou Yien. / Clinical features of radiologically confirmed pneumonia due to adenovirus in children. In: Journal of Clinical Virology. 2013 ; Vol. 56, No. 1. pp. 7-12.
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AB - Background: Clinical features of radiologically confirmed pneumonia due to adenovirus in children have not been comprehensively evaluated. Objective: To describe the detailed clinical features of radiologically confirmed adenovirus-associated pneumonia in children. Study design: Of 3298 children with a throat virus culture positive for adenovirus treated at a university-affiliated hospital, from January 2000 to June 2008, in northern Taiwan, 80 hospitalized children (2.4%) with radiologically confirmed pneumonia were identified. From four children with incomplete medical records, only demographics were included for analysis. Results: The median age was 2.97. years, ranging from 25. days to 14. years. Seventy-three patients (96%) had fever, with a median duration of 7. days. The three most common respiratory symptoms were cough (99%), rhinorrhea (82%) and dyspnea (42%). Gastrointestinal symptoms were recorded in 80% of the patients, and neurologic symptoms in four children. Leukocytosis (WBC. ≥ 15,000/μL) was noted in 19 (25%) patients. Only six patients (8%) had a normal serum C-reactive protein (CRP) value (<5. mg/L), while 48 patients (63%) had a CRP level >40. mg/L. Seventeen (21%) children required intensive care. Seventy-three patients (96%) recovered uneventfully. Sequelae were seen in two patients and death in 1. Of the 69 isolates with serotyping determination, seven serotypes were identified, with a predominant serotype (type 3 for 73%). Conclusion: Less than 5% of the children with adenoviral infection had radiologically confirmed patch pneumonia. The manifestation of pneumonia caused by adenovirus was similar to that of bacterial pneumonia.

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