Clinical features of nosocomial infections by extended-spectrum β-lactamase-producing Enterobacteriaceae in neonatal intensive care units

Shun Chiu, Yhu Chering Huang, Rey In Lien, Yi Hong Chou, Tzou Yien Lin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aim: To determine the risk factors for the acquisition of nosocomial extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae infection in infants hospitalized in neonatal intensive care units (NICUs) and to evaluate the therapeutic outcome of these infants. Methods: We retrospectively reviewed the medical records of infants with nosocomial ESBL-producing Enterobacteriaceae infection hospitalized in NICUs at Chang Gung Children's Hospital in 2001. The clinical features of these infants were compared with a cohort of non-ESBL-producing Enterobacteriaceae -infected infants during the same period. The therapeutic outcome of the infants in the ESBL group was analysed. Results: Seventy infants were included in this study. Thirty-one infants with 34 isolates were identified in the ESBL group and 39 infants with 42 isolates in the non-ESBL group. Of the parameters analysed, including gestational age, birthweight, length of hospital stay before onset, the number of antibiotics used, the duration of third-generation cephalosporin usage and the number of patients receiving a third-generation cephalosporin prior to the onset of infection, no significant difference was found between the two groups. The infection-contributed case fatality rate was 3.0% (1 of 33) in the ESBL group, not significantly different from that in the non-ESBL group (1 of 41, 2.4%). Of the 31 patients in the ESBL group, 18 were treated with a carbapenem as definitive therapy while 13 were treated with a non-carbapenem antibiotic regimen. No significant difference was noted in terms of mortality rate between the two subgroups. Conclusion: The outcome of the infants hospitalized in the NICU with ESBL-producing enterobacterial infections was not indispensably grave, even when treated with a non-carbapenem antibiotic regimen. The risk factors for the acquisition of ESBL-producing enterobacterial infections in these infants were not identified in this series.

Original languageEnglish
Pages (from-to)1644-1649
Number of pages6
JournalActa Paediatrica, International Journal of Paediatrics
Volume94
Issue number11
DOIs
Publication statusPublished - Nov 2005
Externally publishedYes

Fingerprint

Neonatal Intensive Care Units
Enterobacteriaceae
Cross Infection
Enterobacteriaceae Infections
Cephalosporins
Anti-Bacterial Agents
Length of Stay
Carbapenems
Mortality
Infection
Gestational Age
Medical Records
Therapeutics

Keywords

  • Carbapenem
  • Escherichia coli
  • Extended-spectrum β-lactamase
  • Klebsiella pneumoniae
  • Neonatal intensive care unit

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Clinical features of nosocomial infections by extended-spectrum β-lactamase-producing Enterobacteriaceae in neonatal intensive care units. / Chiu, Shun; Huang, Yhu Chering; Lien, Rey In; Chou, Yi Hong; Lin, Tzou Yien.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 94, No. 11, 11.2005, p. 1644-1649.

Research output: Contribution to journalArticle

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abstract = "Aim: To determine the risk factors for the acquisition of nosocomial extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae infection in infants hospitalized in neonatal intensive care units (NICUs) and to evaluate the therapeutic outcome of these infants. Methods: We retrospectively reviewed the medical records of infants with nosocomial ESBL-producing Enterobacteriaceae infection hospitalized in NICUs at Chang Gung Children's Hospital in 2001. The clinical features of these infants were compared with a cohort of non-ESBL-producing Enterobacteriaceae -infected infants during the same period. The therapeutic outcome of the infants in the ESBL group was analysed. Results: Seventy infants were included in this study. Thirty-one infants with 34 isolates were identified in the ESBL group and 39 infants with 42 isolates in the non-ESBL group. Of the parameters analysed, including gestational age, birthweight, length of hospital stay before onset, the number of antibiotics used, the duration of third-generation cephalosporin usage and the number of patients receiving a third-generation cephalosporin prior to the onset of infection, no significant difference was found between the two groups. The infection-contributed case fatality rate was 3.0{\%} (1 of 33) in the ESBL group, not significantly different from that in the non-ESBL group (1 of 41, 2.4{\%}). Of the 31 patients in the ESBL group, 18 were treated with a carbapenem as definitive therapy while 13 were treated with a non-carbapenem antibiotic regimen. No significant difference was noted in terms of mortality rate between the two subgroups. Conclusion: The outcome of the infants hospitalized in the NICU with ESBL-producing enterobacterial infections was not indispensably grave, even when treated with a non-carbapenem antibiotic regimen. The risk factors for the acquisition of ESBL-producing enterobacterial infections in these infants were not identified in this series.",
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T1 - Clinical features of nosocomial infections by extended-spectrum β-lactamase-producing Enterobacteriaceae in neonatal intensive care units

AU - Chiu, Shun

AU - Huang, Yhu Chering

AU - Lien, Rey In

AU - Chou, Yi Hong

AU - Lin, Tzou Yien

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N2 - Aim: To determine the risk factors for the acquisition of nosocomial extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae infection in infants hospitalized in neonatal intensive care units (NICUs) and to evaluate the therapeutic outcome of these infants. Methods: We retrospectively reviewed the medical records of infants with nosocomial ESBL-producing Enterobacteriaceae infection hospitalized in NICUs at Chang Gung Children's Hospital in 2001. The clinical features of these infants were compared with a cohort of non-ESBL-producing Enterobacteriaceae -infected infants during the same period. The therapeutic outcome of the infants in the ESBL group was analysed. Results: Seventy infants were included in this study. Thirty-one infants with 34 isolates were identified in the ESBL group and 39 infants with 42 isolates in the non-ESBL group. Of the parameters analysed, including gestational age, birthweight, length of hospital stay before onset, the number of antibiotics used, the duration of third-generation cephalosporin usage and the number of patients receiving a third-generation cephalosporin prior to the onset of infection, no significant difference was found between the two groups. The infection-contributed case fatality rate was 3.0% (1 of 33) in the ESBL group, not significantly different from that in the non-ESBL group (1 of 41, 2.4%). Of the 31 patients in the ESBL group, 18 were treated with a carbapenem as definitive therapy while 13 were treated with a non-carbapenem antibiotic regimen. No significant difference was noted in terms of mortality rate between the two subgroups. Conclusion: The outcome of the infants hospitalized in the NICU with ESBL-producing enterobacterial infections was not indispensably grave, even when treated with a non-carbapenem antibiotic regimen. The risk factors for the acquisition of ESBL-producing enterobacterial infections in these infants were not identified in this series.

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KW - Escherichia coli

KW - Extended-spectrum β-lactamase

KW - Klebsiella pneumoniae

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