Clinical factors associated with classical symptoms of aortic valve stenosis.

Yuji Nishizaki, Masao Daimon, Sakiko Miyazaki, Hiromasa Suzuki, Takayuki Kawata, Katsumi Miyauchi, Shuo Ju Chiang, Haruka Makinae, Tomohiro Shinozaki, Hiroyuki Daida

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


The recognition of clinical symptoms is critical to a therapeutic strategy for aortic valve stenosis (AS). It was hypothesized that AS symptoms might have multiple causes; hence, a study was conducted to investigate the factors that separately influence the classic symptoms of dyspnea, angina and syncope in AS. The medical records of 170 consecutive patients with AS (> or = moderate grade) were reviewed. A multivariate logistic regression analysis was used to evaluate the hemodynamic and clinical factors that separately influence the development of three clinical symptoms: dyspnea (defined as NYHA class > or = 2), angina, and syncope. The most common symptom was dyspnea (47.1%), followed by angina (12.4%) and syncope (4.7%). The factors associated with dyspnea were a higher e' ratio (p = 0.04) and peak aortic valve velocity (p = 0.01). Only the severity of AS was associated with syncope. The presence of hypertension was associated with angina (p = 0.04). Moreover, coronary angiography was performed in 59 patients before aortic valve replacement and revealed coronary stenosis (> 50% diameter stenosis) in 11/16 patients (69%) that had angina. The presence of coronary stenosis was significantly associated with angina (p = 0.02). The development of dyspnea, angina or syncope was influenced by different factors in AS. Dyspnea and syncope were mainly associated with AS severity, and diastolic dysfunction also influenced dyspnea. In contrast, angina was mainly related to the presence of coronary stenosis rather than to AS severity. These factors should be considered when, selecting a therapeutic strategy for AS patients in the modern era.

Original languageEnglish
Pages (from-to)287-294
Number of pages8
JournalThe Journal of heart valve disease
Issue number3
Publication statusPublished - May 2013
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)


Dive into the research topics of 'Clinical factors associated with classical symptoms of aortic valve stenosis.'. Together they form a unique fingerprint.

Cite this