Clinical experiences of the infections caused by extended-spectrum β-lactamase-producing Serratia marcescens at a Medical Center in Taiwan

Kuo-Chen Cheng, Yin Ching Chuang, Lii Tzu Wu, Guan Cheng Huang, Wen Liang Yu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

CTX-M-3 has become the most common extended-spectrum β-lactamase (ESBL) produced by Serratia marcescens in Taiwan. An expanded effort to detect ESBL among 123 nonrepetitive isolates of S. marcescens was made and 15 (12%) ESBL-producers were identified, all revealing CTX-M-3. Without routinely detecting the ESBL for S. marcescens in clinical laboratories, 80% of the ESBL-producers were reported to be susceptible to cefepime. The clinical spectrum of ESBL-producing S. marcescens-related infections included febrile urinary tract infection (n = 3); afebrile pyuria (n = 2); pneumonia (n = 3); spontaneous bacterial peritonitis (n = 3); secondary bacteremia (n = 2) and one each with primary bacteremia and colonization of the central catheter tip. Overall, the 30-day mortality rate was 33.3% (5/15) and the outcome depended on the severity of the underlying disorder and infection per se. In conclusion, although our case numbers were limited, due to the substantial incidence and associated mortality of ESBL-producing S. marcescens and its potential treatment failure by an apparently susceptible cephalosporin, we recommend that the detection and report of ESBL production for S. marcescens in clinical laboratories be made mandatory.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalJapanese Journal of Infectious Diseases
Volume59
Issue number3
Publication statusPublished - 2006

Fingerprint

Serratia marcescens
Taiwan
Infection
Bacteremia
Pyuria
Mortality
Cephalosporins
Peritonitis
Treatment Failure
Urinary Tract Infections
Pneumonia
Fever
Catheters
Incidence

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Clinical experiences of the infections caused by extended-spectrum β-lactamase-producing Serratia marcescens at a Medical Center in Taiwan. / Cheng, Kuo-Chen; Chuang, Yin Ching; Wu, Lii Tzu; Huang, Guan Cheng; Yu, Wen Liang.

In: Japanese Journal of Infectious Diseases, Vol. 59, No. 3, 2006, p. 147-152.

Research output: Contribution to journalArticle

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