Clinical experience with ganciclovir and anti-cytomegalovirus immunoglobulin treatment for a severe case of congenital cytomegalovirus infection

Yi Hao Weng, Shih Ming Chu, Rey In Lien, Yi Hung Chou, Tzou Yien Lin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We report on a female neonate with severe onset of congenital cytomegalovirus (CMV) infection. She was noted to have cerebral ventriculomegaly on antenatal ultrasound, and presented with petechia after birth. Laboratory tests revealed severe thrombocytopenia (platelet count, 11,000/mm3) and hypoglycemia (serum glucose level, 5 mg/dl). Hepatosplenomegaly with elevated hepatic enzymes, retinitis, conjugated hyperbilirubinemia, and diffuse brainstem anomaly were also found in subsequent examinations. The diagnosis was confirmed by positive CMV-IgM from serum and the isolation of CMV from a urine sample. The patient received intravenous ganciclovir and human anti-CMV immunoglobulin during admission. She was discharged at the age of 61 days and followed-up monthly at our clinics. Symptoms and signs subsided except for mild cerebral ventriculomegaly at her last visit. We demonstrate a successful treatment with the combined use of ganciclovir and anti-CMV immunoglobulin.

Original languageEnglish
Pages (from-to)128-132
Number of pages5
JournalChang Gung Medical Journal
Volume26
Issue number2
Publication statusPublished - Feb 1 2003
Externally publishedYes

Fingerprint

Ganciclovir
Cytomegalovirus Infections
Cytomegalovirus
Immunoglobulins
Hydrocephalus
Retinitis
Hyperbilirubinemia
Purpura
Therapeutics
Serum
Platelet Count
Hypoglycemia
Thrombocytopenia
Brain Stem
Signs and Symptoms
Immunoglobulin M
Urine
Parturition
Newborn Infant
Glucose

Keywords

  • Congenital CMV infection
  • Cytomegalovirus
  • Ganciclovir

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clinical experience with ganciclovir and anti-cytomegalovirus immunoglobulin treatment for a severe case of congenital cytomegalovirus infection. / Weng, Yi Hao; Chu, Shih Ming; Lien, Rey In; Chou, Yi Hung; Lin, Tzou Yien.

In: Chang Gung Medical Journal, Vol. 26, No. 2, 01.02.2003, p. 128-132.

Research output: Contribution to journalArticle

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