Clinical experience using cadaveric skin for wound closure in Taiwan

Yuan-Sheng Tzeng, Shyi-Gen Chen, Niann-Tzyy Dai, Ju-Peng Fu, Shun-Cheng Chang, Shou-Cheng Deng, Fu-Huang Lin, Tim-Mo Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Taiwang's skin banking program was initially set up to provide a ready source of cadaveric skin for patients with severe burns. However, human cadaveric skin may offer a useful alternative to conventional dressings in other wounds as well. Methods. In this retrospective review, cadaveric skin transplantation was used as temporary coverage in 145 patients with chronic ulcers, diabetic foot ulcers (DFU), necrotizing fasciitis, and acute traumatic wounds. Sex, age, number of debridements, and number of cadaveric skin transplantations were analyzed using statistical methods. Results. After clinical determination of engraftment 1 week after cadaveric skin allograft, skin samples harvested for histology in 15 cases revealed migration of epithelia from patientg's skin to the surface of cadaver skin and the presence of granulation tissue in the base of the cadaver skin. All wounds exhibited good wound-bed preparation after cadaveric skin transplantation, and could eventually be resurfaced with a skin autograft. Conclusion. Human cadaveric skin, in addition to being the mainstay in burn therapy, is a good biological dressing for chronic ulcers, DFUs, necrotizing fasciitis, and acute traumatic wounds.
Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalWounds
Volume24
Issue number10
Publication statusPublished - 2012
Externally publishedYes

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Taiwan
Skin
Wounds and Injuries
Skin Transplantation
Necrotizing Fasciitis
Cadaver
Ulcer
Biological Dressings
Diabetic Foot
Granulation Tissue
Autografts
Debridement
Bandages
Burns
Allografts
Histology
Epithelium

Cite this

Tzeng, Y-S., Chen, S-G., Dai, N-T., Fu, J-P., Chang, S-C., Deng, S-C., ... Chen, T-M. (2012). Clinical experience using cadaveric skin for wound closure in Taiwan. Wounds, 24(10), 293-298.

Clinical experience using cadaveric skin for wound closure in Taiwan. / Tzeng, Yuan-Sheng; Chen, Shyi-Gen; Dai, Niann-Tzyy; Fu, Ju-Peng; Chang, Shun-Cheng; Deng, Shou-Cheng; Lin, Fu-Huang; Chen, Tim-Mo.

In: Wounds, Vol. 24, No. 10, 2012, p. 293-298.

Research output: Contribution to journalArticle

Tzeng, Y-S, Chen, S-G, Dai, N-T, Fu, J-P, Chang, S-C, Deng, S-C, Lin, F-H & Chen, T-M 2012, 'Clinical experience using cadaveric skin for wound closure in Taiwan', Wounds, vol. 24, no. 10, pp. 293-298.
Tzeng Y-S, Chen S-G, Dai N-T, Fu J-P, Chang S-C, Deng S-C et al. Clinical experience using cadaveric skin for wound closure in Taiwan. Wounds. 2012;24(10):293-298.
Tzeng, Yuan-Sheng ; Chen, Shyi-Gen ; Dai, Niann-Tzyy ; Fu, Ju-Peng ; Chang, Shun-Cheng ; Deng, Shou-Cheng ; Lin, Fu-Huang ; Chen, Tim-Mo. / Clinical experience using cadaveric skin for wound closure in Taiwan. In: Wounds. 2012 ; Vol. 24, No. 10. pp. 293-298.
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abstract = "Taiwang's skin banking program was initially set up to provide a ready source of cadaveric skin for patients with severe burns. However, human cadaveric skin may offer a useful alternative to conventional dressings in other wounds as well. Methods. In this retrospective review, cadaveric skin transplantation was used as temporary coverage in 145 patients with chronic ulcers, diabetic foot ulcers (DFU), necrotizing fasciitis, and acute traumatic wounds. Sex, age, number of debridements, and number of cadaveric skin transplantations were analyzed using statistical methods. Results. After clinical determination of engraftment 1 week after cadaveric skin allograft, skin samples harvested for histology in 15 cases revealed migration of epithelia from patientg's skin to the surface of cadaver skin and the presence of granulation tissue in the base of the cadaver skin. All wounds exhibited good wound-bed preparation after cadaveric skin transplantation, and could eventually be resurfaced with a skin autograft. Conclusion. Human cadaveric skin, in addition to being the mainstay in burn therapy, is a good biological dressing for chronic ulcers, DFUs, necrotizing fasciitis, and acute traumatic wounds.",
author = "Yuan-Sheng Tzeng and Shyi-Gen Chen and Niann-Tzyy Dai and Ju-Peng Fu and Shun-Cheng Chang and Shou-Cheng Deng and Fu-Huang Lin and Tim-Mo Chen",
note = "被引用次數:1 Export Date: 21 March 2016 通訊地址: Chen, T.-M.; Division of Plastic Surgery, Department of Surgery, Tri-Service General Hospital, Sec. 2, Cheng Kung Road, Nei-Hu 114 Taipei, Taiwan; 電子郵件: doc20383@mail.ndmctsgh.edu.tw 參考文獻: Tompkins, R.G., Hilton, J.F., Burke, J.F., Increased survival after massive thermal injuries in adults: Preliminary report using artificial skin (1989) Crit Care Med, 17, pp. 734-740; Tompkins, R.G., Burke, J.F., Schoenfeld, D.A., Prompt eschar excision: A treatment system contributing to reduced burn mortality: A statistical evaluation of burn care at the Massachusetts General Hospital 1974-1984 (1986) Ann Surg., 204, pp. 272-281; Herndon, D.N., Barrow, R.E., Rutan, R.L., A comparison of conservative versus early excision: Therapies in severely burned patients (1989) Ann Surg, 209, pp. 547-553; Herndon, D.N., Parks, D.H., Comparison of serial debride ment and autografting and early massive excision with cadaver skin overlay in the treatment of large burns in children (1986) J Trauma, 26, pp. 149-152; Desai, M.H., Herndon, D.N., Broemeling, L., Barrow, R.E., Nichols Jr., R.J., Rutan, R.L., Early burn wound excision significantly reduces blood loss (1990) Ann Surg, 211 (6), pp. 753-762; Spence, R.J., Wong, L., The enhancement of wound healing with human skin allograft (1997) Surg Clin North Am, 77 (3), pp. 731-745; Caravaggi, C., Grigoletto, F., Scuderi, N., Wound bed preparation with a dermal substitute (Hyalomatrix {\circledR}PA) Facilitates re-epithelialization and healing: Results of a multicenter, prospective, observational study on complex chronic ulcers (The FAST study) (2011) WOUNDS, 23 (8), pp. 228-235; Greenleaf, G., Hansbrough, J.F., Current trends in the use of allograft skin for patients with burn and reflections on the future of skin banking in the United States (1994) J Burn Care Rehabil, 15 (5), pp. 428-431; Kreis, R.W., Hoekstra, M.J., MacKie, D.P., Vloemans, A.F., Hermans, R.P., Historical appraisal of the use of skin allografts in the treatment of extensive full skin thickness burns at the Red Cross Hospital Burns Centre, Beverwijk, the Netherlands (1992) Burns, 18 (SUPPL. 2), pp. S19-S22; Kangesu, T., Navsaria, A., Manek, S., Kerato-dermal grafts: The importance of dermis for the in vivo growth of cultured keratinocytes (1993) Br J Plast Surg, 46 (5), pp. 401-409; Hickerson, W.L., Compton, C.C., Fletchall, S., Smith, L.R., Cultured epidermal autografts and allodermis combination for permanent wound coverage (1994) Burns, 20 (SUPPL. 1), pp. S52-S56; Langdon, R.C., Cuono, C.B., Birchall, N., Reconstitution of structures and cell function in human skin grafts derived from cryopreserved allogeneic dermis and autologous cultured keratinocytes (1988) J Invest Dermatol, 91 (5), pp. 478-485; Compton, C.C., Hickerson, W.L., Nadire, K., Press, W., Acceleration of skin regeneration from cultured epithelial autografts by transplantation to homograft dermis (1993) J Burn Care Rehabil, 14 (6), pp. 653-662; Livesey, S.A., Herndon, D.N., Hollyoak, M.A., Atkinson, Y.H., Nag, A., Transplanted acellular allograft dermal matrix: Potential as a template for the reconstruction of viable dermis (1995) Transplantation, 60 (1), pp. 1-9; Snyder, R.J., Treatment of nonhealing ulcers with allografts (2005) Clin Dermatol, 23 (4), pp. 388-395; Carucci, J.A., Kolenik III, S.A., Leffell, D.J., Human cadaveric allograft for repair of nasal defects after extirpation of basal cell carcinoma by Mohs micrographic surgery (2002) Dermatol Surg, 28 (4), pp. 340-343; Didomenico, L., Emch, K., Landsman, A.R., Landsman, A., A prospective comparison of diabetic foot ulcers treated with either a cryopreserved skin allgraft or bioengineered skin substitute (2011) WOUNDS, 23 (7), pp. 184-189; Snyder, R.J., Doyle, H., Delbridge, T., Applying split-thickness skin grafts: A step-by-step clinical guide and nursing implications (2001) Ostomy Wound Manage, 47 (11), pp. 20-26; Nowar, M.A., Biswas, A.R., Sundaravadanam, T., Limb salvage in necrotizing fasciitis (2011) WOUNDS, 23 (9), pp. E27-E33; Oliver, A.M., Kaawach, W., Mithoff, E.W., Watt, A., Abramovich, D.R., Rayner, C.R., The differentiation and proliferation of newly formed epidermis on wounds treated with cultured epithelial allografts (1991) Br J Dermatol, 125 (2), pp. 147-154",
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TY - JOUR

T1 - Clinical experience using cadaveric skin for wound closure in Taiwan

AU - Tzeng, Yuan-Sheng

AU - Chen, Shyi-Gen

AU - Dai, Niann-Tzyy

AU - Fu, Ju-Peng

AU - Chang, Shun-Cheng

AU - Deng, Shou-Cheng

AU - Lin, Fu-Huang

AU - Chen, Tim-Mo

N1 - 被引用次數:1 Export Date: 21 March 2016 通訊地址: Chen, T.-M.; Division of Plastic Surgery, Department of Surgery, Tri-Service General Hospital, Sec. 2, Cheng Kung Road, Nei-Hu 114 Taipei, Taiwan; 電子郵件: doc20383@mail.ndmctsgh.edu.tw 參考文獻: Tompkins, R.G., Hilton, J.F., Burke, J.F., Increased survival after massive thermal injuries in adults: Preliminary report using artificial skin (1989) Crit Care Med, 17, pp. 734-740; Tompkins, R.G., Burke, J.F., Schoenfeld, D.A., Prompt eschar excision: A treatment system contributing to reduced burn mortality: A statistical evaluation of burn care at the Massachusetts General Hospital 1974-1984 (1986) Ann Surg., 204, pp. 272-281; Herndon, D.N., Barrow, R.E., Rutan, R.L., A comparison of conservative versus early excision: Therapies in severely burned patients (1989) Ann Surg, 209, pp. 547-553; Herndon, D.N., Parks, D.H., Comparison of serial debride ment and autografting and early massive excision with cadaver skin overlay in the treatment of large burns in children (1986) J Trauma, 26, pp. 149-152; Desai, M.H., Herndon, D.N., Broemeling, L., Barrow, R.E., Nichols Jr., R.J., Rutan, R.L., Early burn wound excision significantly reduces blood loss (1990) Ann Surg, 211 (6), pp. 753-762; Spence, R.J., Wong, L., The enhancement of wound healing with human skin allograft (1997) Surg Clin North Am, 77 (3), pp. 731-745; Caravaggi, C., Grigoletto, F., Scuderi, N., Wound bed preparation with a dermal substitute (Hyalomatrix ®PA) Facilitates re-epithelialization and healing: Results of a multicenter, prospective, observational study on complex chronic ulcers (The FAST study) (2011) WOUNDS, 23 (8), pp. 228-235; Greenleaf, G., Hansbrough, J.F., Current trends in the use of allograft skin for patients with burn and reflections on the future of skin banking in the United States (1994) J Burn Care Rehabil, 15 (5), pp. 428-431; Kreis, R.W., Hoekstra, M.J., MacKie, D.P., Vloemans, A.F., Hermans, R.P., Historical appraisal of the use of skin allografts in the treatment of extensive full skin thickness burns at the Red Cross Hospital Burns Centre, Beverwijk, the Netherlands (1992) Burns, 18 (SUPPL. 2), pp. S19-S22; Kangesu, T., Navsaria, A., Manek, S., Kerato-dermal grafts: The importance of dermis for the in vivo growth of cultured keratinocytes (1993) Br J Plast Surg, 46 (5), pp. 401-409; Hickerson, W.L., Compton, C.C., Fletchall, S., Smith, L.R., Cultured epidermal autografts and allodermis combination for permanent wound coverage (1994) Burns, 20 (SUPPL. 1), pp. S52-S56; Langdon, R.C., Cuono, C.B., Birchall, N., Reconstitution of structures and cell function in human skin grafts derived from cryopreserved allogeneic dermis and autologous cultured keratinocytes (1988) J Invest Dermatol, 91 (5), pp. 478-485; Compton, C.C., Hickerson, W.L., Nadire, K., Press, W., Acceleration of skin regeneration from cultured epithelial autografts by transplantation to homograft dermis (1993) J Burn Care Rehabil, 14 (6), pp. 653-662; Livesey, S.A., Herndon, D.N., Hollyoak, M.A., Atkinson, Y.H., Nag, A., Transplanted acellular allograft dermal matrix: Potential as a template for the reconstruction of viable dermis (1995) Transplantation, 60 (1), pp. 1-9; Snyder, R.J., Treatment of nonhealing ulcers with allografts (2005) Clin Dermatol, 23 (4), pp. 388-395; Carucci, J.A., Kolenik III, S.A., Leffell, D.J., Human cadaveric allograft for repair of nasal defects after extirpation of basal cell carcinoma by Mohs micrographic surgery (2002) Dermatol Surg, 28 (4), pp. 340-343; Didomenico, L., Emch, K., Landsman, A.R., Landsman, A., A prospective comparison of diabetic foot ulcers treated with either a cryopreserved skin allgraft or bioengineered skin substitute (2011) WOUNDS, 23 (7), pp. 184-189; Snyder, R.J., Doyle, H., Delbridge, T., Applying split-thickness skin grafts: A step-by-step clinical guide and nursing implications (2001) Ostomy Wound Manage, 47 (11), pp. 20-26; Nowar, M.A., Biswas, A.R., Sundaravadanam, T., Limb salvage in necrotizing fasciitis (2011) WOUNDS, 23 (9), pp. E27-E33; Oliver, A.M., Kaawach, W., Mithoff, E.W., Watt, A., Abramovich, D.R., Rayner, C.R., The differentiation and proliferation of newly formed epidermis on wounds treated with cultured epithelial allografts (1991) Br J Dermatol, 125 (2), pp. 147-154

PY - 2012

Y1 - 2012

N2 - Taiwang's skin banking program was initially set up to provide a ready source of cadaveric skin for patients with severe burns. However, human cadaveric skin may offer a useful alternative to conventional dressings in other wounds as well. Methods. In this retrospective review, cadaveric skin transplantation was used as temporary coverage in 145 patients with chronic ulcers, diabetic foot ulcers (DFU), necrotizing fasciitis, and acute traumatic wounds. Sex, age, number of debridements, and number of cadaveric skin transplantations were analyzed using statistical methods. Results. After clinical determination of engraftment 1 week after cadaveric skin allograft, skin samples harvested for histology in 15 cases revealed migration of epithelia from patientg's skin to the surface of cadaver skin and the presence of granulation tissue in the base of the cadaver skin. All wounds exhibited good wound-bed preparation after cadaveric skin transplantation, and could eventually be resurfaced with a skin autograft. Conclusion. Human cadaveric skin, in addition to being the mainstay in burn therapy, is a good biological dressing for chronic ulcers, DFUs, necrotizing fasciitis, and acute traumatic wounds.

AB - Taiwang's skin banking program was initially set up to provide a ready source of cadaveric skin for patients with severe burns. However, human cadaveric skin may offer a useful alternative to conventional dressings in other wounds as well. Methods. In this retrospective review, cadaveric skin transplantation was used as temporary coverage in 145 patients with chronic ulcers, diabetic foot ulcers (DFU), necrotizing fasciitis, and acute traumatic wounds. Sex, age, number of debridements, and number of cadaveric skin transplantations were analyzed using statistical methods. Results. After clinical determination of engraftment 1 week after cadaveric skin allograft, skin samples harvested for histology in 15 cases revealed migration of epithelia from patientg's skin to the surface of cadaver skin and the presence of granulation tissue in the base of the cadaver skin. All wounds exhibited good wound-bed preparation after cadaveric skin transplantation, and could eventually be resurfaced with a skin autograft. Conclusion. Human cadaveric skin, in addition to being the mainstay in burn therapy, is a good biological dressing for chronic ulcers, DFUs, necrotizing fasciitis, and acute traumatic wounds.

M3 - Article

VL - 24

SP - 293

EP - 298

JO - Wounds

JF - Wounds

SN - 1044-7946

IS - 10

ER -