TY - JOUR
T1 - Clinical experience using cadaveric skin for wound closure in Taiwan
AU - Tzeng, Yuan-Sheng
AU - Chen, Shyi-Gen
AU - Dai, Niann-Tzyy
AU - Fu, Ju-Peng
AU - Chang, Shun-Cheng
AU - Deng, Shou-Cheng
AU - Lin, Fu-Huang
AU - Chen, Tim-Mo
N1 - 被引用次數：1
Export Date: 21 March 2016
通訊地址: Chen, T.-M.; Division of Plastic Surgery, Department of Surgery, Tri-Service General Hospital, Sec. 2, Cheng Kung Road, Nei-Hu 114 Taipei, Taiwan; 電子郵件： doc20383@mail.ndmctsgh.edu.tw
參考文獻: Tompkins, R.G., Hilton, J.F., Burke, J.F., Increased survival after massive thermal injuries in adults: Preliminary report using artificial skin (1989) Crit Care Med, 17, pp. 734-740; Tompkins, R.G., Burke, J.F., Schoenfeld, D.A., Prompt eschar excision: A treatment system contributing to reduced burn mortality: A statistical evaluation of burn care at the Massachusetts General Hospital 1974-1984 (1986) Ann Surg., 204, pp. 272-281; Herndon, D.N., Barrow, R.E., Rutan, R.L., A comparison of conservative versus early excision: Therapies in severely burned patients (1989) Ann Surg, 209, pp. 547-553; Herndon, D.N., Parks, D.H., Comparison of serial debride ment and autografting and early massive excision with cadaver skin overlay in the treatment of large burns in children (1986) J Trauma, 26, pp. 149-152; Desai, M.H., Herndon, D.N., Broemeling, L., Barrow, R.E., Nichols Jr., R.J., Rutan, R.L., Early burn wound excision significantly reduces blood loss (1990) Ann Surg, 211 (6), pp. 753-762; Spence, R.J., Wong, L., The enhancement of wound healing with human skin allograft (1997) Surg Clin North Am, 77 (3), pp. 731-745; Caravaggi, C., Grigoletto, F., Scuderi, N., Wound bed preparation with a dermal substitute (Hyalomatrix ®PA) Facilitates re-epithelialization and healing: Results of a multicenter, prospective, observational study on complex chronic ulcers (The FAST study) (2011) WOUNDS, 23 (8), pp. 228-235; Greenleaf, G., Hansbrough, J.F., Current trends in the use of allograft skin for patients with burn and reflections on the future of skin banking in the United States (1994) J Burn Care Rehabil, 15 (5), pp. 428-431; Kreis, R.W., Hoekstra, M.J., MacKie, D.P., Vloemans, A.F., Hermans, R.P., Historical appraisal of the use of skin allografts in the treatment of extensive full skin thickness burns at the Red Cross Hospital Burns Centre, Beverwijk, the Netherlands (1992) Burns, 18 (SUPPL. 2), pp. S19-S22; Kangesu, T., Navsaria, A., Manek, S., Kerato-dermal grafts: The importance of dermis for the in vivo growth of cultured keratinocytes (1993) Br J Plast Surg, 46 (5), pp. 401-409; Hickerson, W.L., Compton, C.C., Fletchall, S., Smith, L.R., Cultured epidermal autografts and allodermis combination for permanent wound coverage (1994) Burns, 20 (SUPPL. 1), pp. S52-S56; Langdon, R.C., Cuono, C.B., Birchall, N., Reconstitution of structures and cell function in human skin grafts derived from cryopreserved allogeneic dermis and autologous cultured keratinocytes (1988) J Invest Dermatol, 91 (5), pp. 478-485; Compton, C.C., Hickerson, W.L., Nadire, K., Press, W., Acceleration of skin regeneration from cultured epithelial autografts by transplantation to homograft dermis (1993) J Burn Care Rehabil, 14 (6), pp. 653-662; Livesey, S.A., Herndon, D.N., Hollyoak, M.A., Atkinson, Y.H., Nag, A., Transplanted acellular allograft dermal matrix: Potential as a template for the reconstruction of viable dermis (1995) Transplantation, 60 (1), pp. 1-9; Snyder, R.J., Treatment of nonhealing ulcers with allografts (2005) Clin Dermatol, 23 (4), pp. 388-395; Carucci, J.A., Kolenik III, S.A., Leffell, D.J., Human cadaveric allograft for repair of nasal defects after extirpation of basal cell carcinoma by Mohs micrographic surgery (2002) Dermatol Surg, 28 (4), pp. 340-343; Didomenico, L., Emch, K., Landsman, A.R., Landsman, A., A prospective comparison of diabetic foot ulcers treated with either a cryopreserved skin allgraft or bioengineered skin substitute (2011) WOUNDS, 23 (7), pp. 184-189; Snyder, R.J., Doyle, H., Delbridge, T., Applying split-thickness skin grafts: A step-by-step clinical guide and nursing implications (2001) Ostomy Wound Manage, 47 (11), pp. 20-26; Nowar, M.A., Biswas, A.R., Sundaravadanam, T., Limb salvage in necrotizing fasciitis (2011) WOUNDS, 23 (9), pp. E27-E33; Oliver, A.M., Kaawach, W., Mithoff, E.W., Watt, A., Abramovich, D.R., Rayner, C.R., The differentiation and proliferation of newly formed epidermis on wounds treated with cultured epithelial allografts (1991) Br J Dermatol, 125 (2), pp. 147-154
PY - 2012
Y1 - 2012
N2 - Taiwang's skin banking program was initially set up to provide a ready source of cadaveric skin for patients with severe burns. However, human cadaveric skin may offer a useful alternative to conventional dressings in other wounds as well. Methods. In this retrospective review, cadaveric skin transplantation was used as temporary coverage in 145 patients with chronic ulcers, diabetic foot ulcers (DFU), necrotizing fasciitis, and acute traumatic wounds. Sex, age, number of debridements, and number of cadaveric skin transplantations were analyzed using statistical methods. Results. After clinical determination of engraftment 1 week after cadaveric skin allograft, skin samples harvested for histology in 15 cases revealed migration of epithelia from patientg's skin to the surface of cadaver skin and the presence of granulation tissue in the base of the cadaver skin. All wounds exhibited good wound-bed preparation after cadaveric skin transplantation, and could eventually be resurfaced with a skin autograft. Conclusion. Human cadaveric skin, in addition to being the mainstay in burn therapy, is a good biological dressing for chronic ulcers, DFUs, necrotizing fasciitis, and acute traumatic wounds.
AB - Taiwang's skin banking program was initially set up to provide a ready source of cadaveric skin for patients with severe burns. However, human cadaveric skin may offer a useful alternative to conventional dressings in other wounds as well. Methods. In this retrospective review, cadaveric skin transplantation was used as temporary coverage in 145 patients with chronic ulcers, diabetic foot ulcers (DFU), necrotizing fasciitis, and acute traumatic wounds. Sex, age, number of debridements, and number of cadaveric skin transplantations were analyzed using statistical methods. Results. After clinical determination of engraftment 1 week after cadaveric skin allograft, skin samples harvested for histology in 15 cases revealed migration of epithelia from patientg's skin to the surface of cadaver skin and the presence of granulation tissue in the base of the cadaver skin. All wounds exhibited good wound-bed preparation after cadaveric skin transplantation, and could eventually be resurfaced with a skin autograft. Conclusion. Human cadaveric skin, in addition to being the mainstay in burn therapy, is a good biological dressing for chronic ulcers, DFUs, necrotizing fasciitis, and acute traumatic wounds.
M3 - Article
VL - 24
SP - 293
EP - 298
JO - Wounds
JF - Wounds
SN - 1044-7946
IS - 10
ER -